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UID:a9c46cc8-8905-4783-b614-c5ae54207296
DTSTAMP:20261028T122443Z
SUMMARY:Evaluating the Catalytic Efficiency of a Protease Enzyme Using AuNP
 -Peptide-dye Assemblies
DESCRIPTION:<p style="text-align: justify\;"><strong>Nanoseminar in&nbsp\;C
 hemistry and Materials</strong></p>\n<p style="text-align: justify\;"><str
 ong>IN PERSON&nbsp\;EVENT -</strong><strong>&nbsp\;REGISTER&nbsp\;<a href=
 "https://forms.office.com/e/29Ug7dN9Bk">HERE</a></strong><a href="https://
 forms.office.com/e/29Ug7dN9Bk">&nbsp\;</a>to attend.</p>\n<p style="text-a
 lign: justify\;">By P<strong>rof.&nbsp\;Hedi Mattoussi</strong><strong>—
 </strong>Department of Chemistry and Biochemistry\, Florida State Universi
 ty\, United States</p>\n<p style="text-align: justify\;"><strong>Abstract<
 /strong>:We combine AuNP-peptide-dye conjugates and energy transfer intera
 ctions to evaluate the catalytic activity of the enzyme MMP-14\, a cancer 
 biomarker. We exploit the time-dependent dye emission recovery\, triggered
  by hydrolysis of the peptide-dye\, to extract information about the time-
 dependent peptide digestion. We use the data to develop a quantitative ana
 lysis of the proteolysis kinetics. Overall\, our hybrid bioconjugates have
  achieved sub-nanomolar detection limits. In addition\, we use theoretical
  considerations within a diffusion-collision framework\, to understand pro
 teolysis of nanosurface-immobilized substrates. Our findings offer a great
  strategy for developping sensitive biosensors for cancer detection and im
 aging.</p>\n<p style="text-align: justify\;"><strong>Short Bio:&nbsp\;</st
 rong></p>\n<p><strong>Hedi Mattoussi </strong>is a Distinguished Research 
 Professor at Florida State University\, Tallahassee. Prior to joining FSU 
 in 2009\, he spent 12 years as a Research Scientist at the US Naval Resear
 ch Laboratory (Washington). After graduating with a Bachelor in Physics fr
 om the University of Tunis El Manar (Tunisia) in 1982\, he earned a Ph.D. 
 in Condensed Matter Physics in 1987 and a Habilitation to direct Research 
 in Materials Physics in 1994\, both from Sorbonne University\, University 
 of Pierre &amp\; Marie Curie Campus. He presently focuses on the developme
 nt of inorganic nanocolloids and transition metal clusters and interfacing
  them with biological systems. Professor Mattoussi is a fellow of the Amer
 ican Chemical Society\, ACS (class of 2011)\, the American Physical societ
 y\, APS (class of 2013) the Royal Society of Chemistry\, RSC (class of 201
 4)\, and the Materials Research Society\, MRS (class of 2020). He was awar
 ded the 2022 Kuwait Prize (sponsored by the Kuwait Foundation for the Adva
 ncement of Sciences\, KFAS) and the 2024 American Chemical Society (ACS) A
 ward in Surface Chemistry.</p>\n<p>Homepage: <a href="http://www.chem.fsu.
 edu/~mattoussi/">http://www.chem.fsu.edu/~mattoussi/</a>&nbsp\;</p>\n<p st
 yle="text-align: justify\;">Hosted by&nbsp\;<strong>Prof. Javier Rodrígue
 z-Viejo</strong>\, UAB Professor and&nbsp\;<a href="/en/thermal-properties
 -of-nanoscale-materials">Thermal Properties of Nanoscale Materials</a>&nbs
 p\;Senior Group Leader</p>
DTSTART:20260108T140000
DTEND:20260108T225959
LOCATION:ICN2 Seminar Room\, Campus UAB
CATEGORIES:NanoSeminars
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