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DTSTAMP:20261028T122443Z
SUMMARY:Nanophotonic biosensors for rapid and precision diagnostics in glob
 al infectious threats
DESCRIPTION:<p><strong>PhD:&nbsp\;Beatriz Serrano do Couto</strong></p>\n<p
 ><strong>Director</strong>:</p>\n<p>Dr Maria Soler\, Senior Researcher\, <
 a href="/en/nanobiosensors-and-bioanalytical-applications-group">NanoBiose
 nsors and Bioanalytical Applications</a>&nbsp\;group ICN2</p>\n<p><strong>
 Short Abstract:</strong></p>\n<p>This PhD Thesis develops and analytically
  validates nanophotonic biosensors for rapid\, precise molecular diagnosis
  of infectious diseases. It addresses two major challenges: surveillance o
 f zoonotic coronaviruses at the animal–human interface\, and diagnosis o
 f bacterial sexually transmitted infections and antimicrobial resistance m
 arkers. Surface plasmon resonance and bimodal waveguide interferometry wer
 e investigated for direct\, label-free detection of pathogen-specific RNA 
 and DNA sequences. Robust nucleic acid biofunctionalization strategies wer
 e established for gold and silicon nitride surfaces by optimizing surface 
 chemistry\, probe immobilization\, hybridization conditions\, and regenera
 tion. Coronavirus assays were developed and validated using synthetic targ
 ets\, in vitro transcribed RNA\, and animal-derived samples\, demonstratin
 g applicability to wildlife and veterinary surveillance. The work was exte
 nded to <em>Neisseria gonorrhoeae</em> and <em>Chlamydia trachomatis</em> 
 and to discrimination of a clinically relevant single-nucleotide mutation 
 linked to ciprofloxacin resistance. Overall\, this Thesis establishes a fr
 amework for label-free nucleic acid detection with potential integration i
 nto multiplexed\, automated\, portable diagnostic platforms.</p>\n<p>REGIS
 TER <a href="https://forms.cloud.microsoft/Pages/ResponsePage.aspx?id=7y7I
 tE2bfUi-qg79NXo6WxH4jECG9S9KmyGb2KoqlQpUMTBDVE1HS1hONjhZQlFYME04TjFLMjZNRy
 QlQCN0PWcu">HERE</a></p>
DTSTART:20260914T090000
DTEND:20260914T215959
LOCATION:ICN2 Seminar Room
CATEGORIES:ICN2 Theses Defence
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