Nanomedicine

Group Leader: Kostas Kostarelos

Kostas Kostarelos

Kostas Kostarelos

Severo Ochoa Distinguished Professor and Group Leader

kostas.kostarelos@icn2.cat

Group Leader

Prof. Kostas Kostarelos read Chemistry at the University of Leeds and obtained his Diploma in Chemical Engineering and his PhD from the Department of Chemical Engineering at Imperial College London, studying the steric stabilization of liposomes using block copolymer molecules.

He carried out his postdoctoral training in various medical institutions in the USA (UCSF, Memorial Sloan-Kettering Cancer Center, Cornell). Following his promotion to Assistant Professor of Genetic Medicine and Chemical Engineering in Medicine at Cornell University Weill Medical College, he relocated to the UK as the Deputy Director of Imperial College Genetic Therapies Centre in 2002. In 2007 Kostarelos was awarded the first personal Chair of Nanomedicine in the UK and was Head of the Centre for Drug Delivery at the UCL School of Pharmacy in London.

The whole Nanomedicine Lab was recruited by the University of Manchester in 2013, while Prof. Kostarelos also maintained an Honorary Professorship with University College London.

Currently, Kostarelos is Professor and Chair of Nanomedicine at the Faculty of Biology, Medicine and Health, leads the Nanomedicine Lab and is a member of the National Graphene Institute and the Manchester Cancer Research Centre, all at the University of Manchester. He has been invited to Fellowships with the Royal Society of Chemistry, Royal Society of Medicine and Royal Society of Arts, all in the UK. He was awarded the Japanese Society for the Promotion of Science (JSPS) Professorial Fellowship in 2010.

In 2019 he joined the ICN2 as Severo Ochoa Distinguished Professor and Group Leader, while retaining his appointments and research team at the University of Manchester.

Publications

2022

  • Full-bandwidth electrophysiology of seizures and epileptiform activity enabled by flexible graphene microtransistor depth neural probes

    Bonaccini Calia A., Masvidal-Codina E., Smith T.M., Schäfer N., Rathore D., Rodríguez-Lucas E., Illa X., De la Cruz J.M., Del Corro E., Prats-Alfonso E., Viana D., Bousquet J., Hébert C., Martínez-Aguilar J., Sperling J.R., Drummond M., Halder A., Dodd A., Barr K., Savage S., Fornell J., Sort J., Guger C., Villa R., Kostarelos K., Wykes R.C., Guimerà-Brunet A., Garrido J.A. Nature Nanotechnology; 17 (3): 301 - 309. 2022. 10.1038/s41565-021-01041-9. IF: 39.213

  • Innate but Not Adaptive Immunity Regulates Lung Recovery from Chronic Exposure to Graphene Oxide Nanosheets

    Loret T., de Luna L.A.V., Fordham A., Arshad A., Barr K., Lozano N., Kostarelos K., Bussy C. Advanced Science; 2022. 10.1002/advs.202104559. IF: 16.806

2021

  • A method for the measurement of mass and number of graphene oxide sheets in suspension based on non-spherical approximations

    Crica L.E., Dennison T.J., Guerini E.A., Kostarelos K. 2D Materials; 8 (3, 035044) 2021. 10.1088/2053-1583/abfe01. IF: 7.103

  • Adenoviral Mediated Delivery of OSKM Factors Induces Partial Reprogramming of Mouse Cardiac Cells In Vivo

    Kisby T., de Lázaro I., Fisch S., Cartwright E.J., Cossu G., Kostarelos K. Advanced Therapeutics; 4 (2, 2000141) 2021. 10.1002/adtp.202000141. IF: 0.000

  • Deep Tissue Translocation of Graphene Oxide Sheets in Human Glioblastoma 3D Spheroids and an Orthotopic Xenograft Model

    de Lázaro I., Sharp P., Gurcan C., Ceylan A., Stylianou M., Kisby T., Chen Y., Vranic S., Barr K., Taheri H., Ozen A., Bussy C., Yilmazer A., Kostarelos K. Advanced Therapeutics; 4 (1, 2000109) 2021. 10.1002/adtp.202000109. IF: 0.000

  • Graphene active sensor arrays for long-term and wireless mapping of wide frequency band epicortical brain activity

    Garcia-Cortadella R., Schwesig G., Jeschke C., Illa X., Gray A.L., Savage S., Stamatidou E., Schiessl I., Masvidal-Codina E., Kostarelos K., Guimerà-Brunet A., Sirota A., Garrido J.A. Nature Communications; 12 (1, 211) 2021. 10.1038/s41467-020-20546-w. IF: 14.919

  • Graphene Oxide Nanosheets Interact and Interfere with SARS-CoV-2 Surface Proteins and Cell Receptors to Inhibit Infectivity

    Unal M.A., Bayrakdar F., Nazir H., Besbinar O., Gurcan C., Lozano N., Arellano L.M., Yalcin S., Panatli O., Celik D., Alkaya D., Agan A., Fusco L., Suzuk Yildiz S., Delogu L.G., Akcali K.C., Kostarelos K., Yilmazer A. Small; 17 (25, 2101483) 2021. 10.1002/smll.202101483. IF: 13.281

  • Graphene oxide prevents lateral amygdala dysfunctional synaptic plasticity and reverts long lasting anxiety behavior in rats

    Franceschi Biagioni A., Cellot G., Pati E., Lozano N., Ballesteros B., Casani R., Coimbra N.C., Kostarelos K., Ballerini L. Biomaterials; 271 (120749) 2021. 10.1016/j.biomaterials.2021.120749. IF: 12.479

  • Nanotools for Sepsis Diagnosis and Treatment

    Papafilippou L., Claxton A., Dark P., Kostarelos K., Hadjidemetriou M. Advanced Healthcare Materials; 10 (1, 2001378) 2021. 10.1002/adhm.202001378. IF: 9.933

  • Reasons for success and lessons learnt from nanoscale vaccines against COVID-19

    Kisby T., Yilmazer A., Kostarelos K. Nature Nanotechnology; 16 (8): 843 - 850. 2021. 10.1038/s41565-021-00946-9. IF: 39.213

  • Shedding plasma membrane vesicles induced by graphene oxide nanoflakes in brain cultured astrocytes

    Musto M., Parisse P., Pachetti M., Memo C., Di Mauro G., Ballesteros B., Lozano N., Kostarelos K., Casalis L., Ballerini L. Carbon; 176: 458 - 469. 2021. 10.1016/j.carbon.2021.01.142. IF: 9.594

  • The impact of graphene oxide sheet lateral dimensions on their pharmacokinetic and tissue distribution profiles in mice

    Jasim D.A., Newman L., Rodrigues A.F., Vacchi I.A., Lucherelli M.A., Lozano N., Ménard-Moyon C., Bianco A., Kostarelos K. Journal of Controlled Release; 338: 330 - 340. 2021. 10.1016/j.jconrel.2021.08.028. IF: 9.776

  • Transient reprogramming of postnatal cardiomyocytes to a dedifferentiated state

    Kisby T., de Lázaro I., Stylianou M., Cossu G., Kostarelos K. PLoS ONE; 16 (5 May, e0251054) 2021. 10.1371/journal.pone.0251054. IF: 3.240

  • Trends in Micro-/Nanorobotics: Materials Development, Actuation, Localization, and System Integration for Biomedical Applications

    Wang B., Kostarelos K., Nelson B.J., Zhang L. Advanced Materials; 33 (4, 2002047) 2021. 10.1002/adma.202002047. IF: 30.849

  • Viscoelastic surface electrode arrays to interface with viscoelastic tissues

    Tringides C.M., Vachicouras N., de Lázaro I., Wang H., Trouillet A., Seo B.R., Elosegui-Artola A., Fallegger F., Shin Y., Casiraghi C., Kostarelos K., Lacour S.P., Mooney D.J. Nature Nanotechnology; 16 (9): 1019 - 1029. 2021. 10.1038/s41565-021-00926-z. IF: 39.213

2020

  • Banning carbon nanotubes would be scientifically unjustified and damaging to innovation

    Heller D.A., Jena P.V., Pasquali M., Kostarelos K., Delogu L.G., Meidl R.E., Rotkin S.V., Scheinberg D.A., Schwartz R.E., Terrones M., Wang Y.H., Bianco A., Boghossian A.A., Cambré S., Cognet L., Corrie S.R., Demokritou P., Giordani S., Hertel T., Ignatova T., Islam M.F., Iverson N.M., Jagota A., Janas D., Kono J., Kruss S., Landry M.P., Li Y., Martel R., Maruyama S., Naumov A.V., Prato M., Quinn S.J., Roxbury D., Strano M.S., Tour J.M., Weisman R.B., Wenseleers W., Yudasaka M. Nature Nanotechnology; 15 (3): 164 - 166. 2020. 10.1038/s41565-020-0656-y. IF: 31.538

  • Graphene, other carbon nanomaterials and the immune system: toward nanoimmunity-by-design

    Arianna Gazzi, Laura Fusco, Marco Orecchioni, Silvia Ferrari, Giulia Franzoni, J Stephen Yan, Matthias Rieckher, Guotao Peng, Matteo Andrea Lucherelli, Isabella Anna Vacchi, Ngoc Do Quyen Chau, Alejandro Criado, Akcan Istif, Donato Mancino, Antonio Dominguez, Hagen Eckert, Ester Vázquez, Tatiana Da Ros, Paola Nicolussi, Vincenzo Palermo, Björn Schumacher, Gianaurelio Cuniberti, Yiyong Mai, Cecilia Clementi, Matteo Pasquali, Xinliang Feng, Kostas Kostarelos, Acelya Yilmazer, Davide BedognettI, Bengt Fadeel, Maurizio Prato, Alberto Bianco and Lucia Gemma Delogu Journal of Physics: Materials; 3 (34009) 2020. 10.1088/2515-7639/ab9317. IF: 0.000

  • Grouping all carbon nanotubes into a single substance category is scientifically unjustified

    Fadeel B., Kostarelos K. Nature Nanotechnology; 15 (3): 164. 2020. 10.1038/s41565-020-0654-0. IF: 31.538

  • Intracerebral Injection of Graphene Oxide Nanosheets Mitigates Microglial Activation Without Inducing Acute Neurotoxicity: A Pilot Comparison to Other Nanomaterials

    Portioli C., Bussy C., Mazza M., Lozano N., Jasim D.A., Prato M., Bianco A., Bentivoglio M., Kostarelos K. Small; 16 (48, 2004029) 2020. 10.1002/smll.202004029. IF: 11.459

  • Multiparametric Profiling of Engineered Nanomaterials: Unmasking the Surface Coating Effect

    Gallud A., Delaval M., Kinaret P., Marwah V.S., Fortino V., Ytterberg J., Zubarev R., Skoog T., Kere J., Correia M., Loeschner K., Al-Ahmady Z., Kostarelos K., Ruiz J., Astruc D., Monopoli M., Handy R., Moya S., Savolainen K., Alenius H., Greco D., Fadeel B. Advanced Science; 7 (22, 2002221) 2020. 10.1002/advs.202002221. IF: 15.840

  • Nano-scavengers for blood biomarker discovery in ovarian carcinoma

    Hadjidemetriou M., Papafilippou L., Unwin R.D., Rogan J., Clamp A., Kostarelos K. Nano Today; 34 (100901) 2020. 10.1016/j.nantod.2020.100901. IF: 16.907

  • Nanoscale nights of COVID-19

    Kostarelos K. Nature Nanotechnology; 15 (5): 343 - 344. 2020. 10.1038/s41565-020-0687-4. IF: 31.538

  • Nitric oxide-dependent biodegradation of graphene oxide reduces inflammation in the gastrointestinal tract

    Peng G., Montenegro M.F., Ntola C.N.M., Vranic S., Kostarelos K., Vogt C., Toprak M.S., Duan T., Leifer K., Bräutigam L., Lundberg J.O., Fadeel B. Nanoscale; 12 (32): 16730 - 16737. 2020. 10.1039/d0nr03675g. IF: 6.895

  • Production and processing of graphene and related materials

    Backes C., Abdelkader A.M., Alonso C., Andrieux-Ledier A., Arenal R., Azpeitia J., Balakrishnan N., Banszerus L., Barjon J., Bartali R., Bellani S., Berger C., Berger R., Ortega M.M.B., Bernard C., Beton P.H., Beyer A., Bianco A., Bøggild P., Bonaccorso F., Barin G.B., Botas C., Bueno R.A., Carriazo D., Castellanos-Gomez A., Christian M., Ciesielski A., Ciuk T., Cole M.T., Coleman J., Coletti C., Crema L., Cun H., Dasler D., De Fazio D., Díez N., Drieschner S., Duesberg G.S., Fasel R., Feng X., Fina A., Forti S., Galiotis C., Garberoglio G., García J.M., Garrido J.A., Gibertini M., Gölzhäuser A., Gómez J., Greber T., Hauke F., Hemmi A., Hernandez-Rodriguez I., Hirsch A., Hodge S.A., Huttel Y., Jepsen P.U., Jimenez I., Kaiser U., Kaplas T., Kim H., Kis A., Papagelis K., Kostarelos K., Krajewska A., Lee K., Li C., Lipsanen H., Liscio A., Lohe M.R., Loiseau A., Lombardi L., López M.F., Martin O., Martín C., Martínez L., Martin-Gago J.A., Martínez J.I., Marzari N., Mayoral A., McManus J., Melucci M., Méndez J., Merino C., Merino P., Meyer A.P., Miniussi E., Miseikis V., Mishra N., Morandi V., Munuera C., Muñoz R., Nolan H., Ortolani L., Ott A.K., Palacio I., Palermo V., Parthenios J., Paste 2D Materials; 7 (2, 022001) 2020. 10.1088/2053-1583/ab1e0a. IF: 7.140

  • Protein corona fingerprinting to differentiate sepsis from non-infectious systemic inflammation

    Papafilippou L., Claxton A., Dark P., Kostarelos K., Hadjidemetriou M. Nanoscale; 12 (18): 10240 - 10253. 2020. 10.1039/d0nr02788j. IF: 6.895

  • Size-Dependent Pulmonary Impact of Thin Graphene Oxide Sheets in Mice: Toward Safe-by-Design

    Rodrigues A.F., Newman L., Jasim D., Mukherjee S.P., Wang J., Vacchi I.A., Ménard-Moyon C., Bianco A., Fadeel B., Kostarelos K., Bussy C. Advanced Science; 7 (12, 1903200) 2020. 10.1002/advs.201903200. IF: 15.840

  • Splenic Capture and in Vivo Intracellular Biodegradation of Biological-Grade Graphene Oxide Sheets

    Newman L., Jasim D.A., Prestat E., Lozano N., De Lazaro I., Nam Y., Assas B.M., Pennock J., Haigh S.J., Bussy C., Kostarelos K. ACS Nano; 14 (8): 10168 - 10186. 2020. 10.1021/acsnano.0c03438. IF: 14.588

  • Stable, concentrated, biocompatible, and defect-free graphene dispersions with positive charge

    Shin Y., Vranic S., Just-Baringo X., Gali S.M., Kisby T., Chen Y., Gkoutzidou A., Prestat E., Beljonne D., Larrosa I., Kostarelos K., Casiraghi C. Nanoscale; 12 (23): 12383 - 12394. 2020. 10.1039/d0nr02689a. IF: 6.895

  • The biomolecule corona of lipid nanoparticles contains circulating cell-free DNA

    Gardner L., Warrington J., Rogan J., Rothwell D.G., Brady G., Dive C., Kostarelos K., Hadjidemetriou M. Nanoscale Horizons; 5 (11): 1476 - 1486. 2020. 10.1039/d0nh00333f. IF: 9.927

2019

  • Non-cytotoxic carbon nanocapsules synthesized via one-pot filling and end-closing of multi-walled carbon nanotubes

    Martincic M., Vranic S., Pach E., Sandoval S., Ballesteros B., Kostarelos K., Tobias G. Carbon; 141: 782 - 793. 2019. 10.1016/j.carbon.2018.10.006. IF: 7.466

2017

  • Graphene in the Design and Engineering of Next-Generation Neural Interfaces

    Kostarelos K., Vincent M., Hebert C., Garrido J.A. Advanced Materials; 29 (42, 1700909) 2017. 10.1002/adma.201700909. IF: 19.791

2016

  • Gadolinium-functionalised multi-walled carbon nanotubes as a T1 contrast agent for MRI cell labelling and tracking

    Servant A., Jacobs I., Bussy C., Fabbro C., Da Ros T., Pach E., Ballesteros B., Prato M., Nicolay K., Kostarelos K. Carbon; 97: 126 - 133. 2016. 10.1016/j.carbon.2015.08.051. IF: 6.198

2010

  • Filled and glycosylated carbon nanotubes for in vivo radioemitter localization and imaging

    You Hong, S.; Tobias, G.; Al-Jamal, K.T.; Ballesteros, B.; Ali-Boucetta, H.; Lozano-Perez, S.; Nellist, P.D.; Sim, R.B.; Finucane, C.; Mather, S.J.; Green, M.L.H.; Kostarelos, K.; Davis, B.G. Nature Materials; 2010. .

More publications by Prof. Kostas Kostarelos