Nanoseminar in Chemistry and Materials
IN PERSON EVENT - REGISTER HERE to attend.
By Prof. Hedi Mattoussi—Department of Chemistry and Biochemistry, Florida State University, United States
Abstract:We combine AuNP-peptide-dye conjugates and energy transfer interactions to evaluate the catalytic activity of the enzyme MMP-14, a cancer biomarker. We exploit the time-dependent dye emission recovery, triggered by hydrolysis of the peptide-dye, to extract information about the time-dependent peptide digestion. We use the data to develop a quantitative analysis of the proteolysis kinetics. Overall, our hybrid bioconjugates have achieved sub-nanomolar detection limits. In addition, we use theoretical considerations within a diffusion-collision framework, to understand proteolysis of nanosurface-immobilized substrates. Our findings offer a great strategy for developping sensitive biosensors for cancer detection and imaging.
Short Bio:
Hedi Mattoussi is a Distinguished Research Professor at Florida State University, Tallahassee. Prior to joining FSU in 2009, he spent 12 years as a Research Scientist at the US Naval Research Laboratory (Washington). After graduating with a Bachelor in Physics from the University of Tunis El Manar (Tunisia) in 1982, he earned a Ph.D. in Condensed Matter Physics in 1987 and a Habilitation to direct Research in Materials Physics in 1994, both from Sorbonne University, University of Pierre & Marie Curie Campus. He presently focuses on the development of inorganic nanocolloids and transition metal clusters and interfacing them with biological systems. Professor Mattoussi is a fellow of the American Chemical Society, ACS (class of 2011), the American Physical society, APS (class of 2013) the Royal Society of Chemistry, RSC (class of 2014), and the Materials Research Society, MRS (class of 2020). He was awarded the 2022 Kuwait Prize (sponsored by the Kuwait Foundation for the Advancement of Sciences, KFAS) and the 2024 American Chemical Society (ACS) Award in Surface Chemistry.
Homepage: http://www.chem.fsu.edu/~mattoussi/
Hosted by Prof. Javier Rodríguez-Viejo, UAB Professor and Thermal Properties of Nanoscale Materials Senior Group Leader