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PhD Student: Razia Batool

Directors: CSIC Prof. Laura M. Lechuga and Dr Maria Soler, Group Leader and Senior Researcher, respectively, at the NanoBiosensors and Bioanalytical Applications Group, ICN2.

Short Abstract: This PhD thesis focuses on the development of new nanophotonic biosensors for the screening and evaluation of immunotherapies for cancer and infectious diseases. In particular, the objective is to simplify and accelerate the selection and assessment of monoclonal antibodies (mAb) either as immune checkpoint inhibitors or anti-viral therapy. The research initially explores the design and large-scale fabrication of short-ordered arrays of plasmonic nanostructures as well as novel dielectric nanoresonators. These nanosensors are integrated in compact and user-friendly devices for simple operation and straigthforward application in biomedical analysis. In addition, an innovative sensor biofunctionalization protocol is proposed for creating on-chip artificial cell membranes, providing a nature-inspired microenvironment that enhances the efficiency of biomolecular interactions. To demonstrate the utility and benefits of these biomimetic nanophotonic sensors, two relevant applications are presented: the screening of mAb candidates as anti-viral therapy for COVID-19 and the evaluation of immune checkpoint inhibitors targeting the programmed cell death (PD1) pathway. The technological and biochemical advances accomplished in this thesis offer a promising potential for diverse applications in biomedical research, including precision diagnostics, therapeutic formulation, and personalized medicine.