NanoBiosensors and Bioanalytical Applications
Group Leader: Laura M. Lechuga
Laura M. Lechuga
CSIC Research Professor
Group Leader
Prof. Laura M. Lechuga received her PhD in Chemistry from the Universidad Complutense de Madrid (Spain) in 1992. She is Full Professor of the Spanish National Research Council (CSIC) and Head of the Nanobiosensors and Bioanalytical Applications Group at the Catalan Institute of Nanoscience and Nanotechnology (ICN2) in Barcelona (Spain) and at the Networking Biomedical Research Center (CIBER-BBN).
The principal focus of her research is the development of novel nanobiosensor devices based on Nanoplasmonics and Silicon photonics principles for point-of-care diagnostics. Prof. Lechuga is a world reference in the Photonic Biosensor area, making key contributions and opening new horizons in this field. Her research activities cover from fundamental research to the technological operation of complete sensing platforms, including the technological transfer into products of social applicability. Her Group is considered as a world reference in this field.
She has published over 300 publications (articles, book chapters and proceedings), has 8 families of patents and 4 trade secrets, and has presented her work worldwide in more than 490 invited talks. She has co-founded two spin-off companies. She is Associate Editor for international journals in the field of engineering, chemistry, and optics, belongs to the Scientific Advisory Committees of highly prestigious national and international institutions and has participated regularly in high-level international scientific evaluation panels (such as Panel Chair for ERC Adv. grants).
The quality of her research has been recognised with prestigious prizes and awards, such as the Spanish National Research Prize in 2020, the King Jaume I Award in New Technologies in 2020, the Ada Byron 2020 Prize, the Physics, Innovation and Technology Prize from the Spanish Royal Physics Society (RSEF) and BBVA Foundation in 2016, the XVIII Burdinola Research Award in 2021, the 2021 Medal of the International Foundation Olof Palme, the Doctorate Honoris Causa awarded by the University of Cádiz, the Lung Ambition Alliance Prize from AstraZeneca, and the National Prize in Nanotechnology (2023), among others.
In addition, she has been carrying out a significant science dissemination activity for more than 25 years, being one of the national pioneers in this field, with more than 250 TV, radio, podcast, social media, press interviews, as well as conferences and articles fro scientific popularisation at national and international level
From April 2020 to September 2021, she belonged to the Expert Scientific Panel advising the Ministry of Science and Innovation and the Spanish Government in the management of the COVID-19 pandemic.
Publications
2024
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A novel biomimetic nanoplasmonic sensor for rapid and accurate evaluation of checkpoint inhibitor immunotherapy
Batool, Razia; Soler, Maria; Singh, Rukmani; Lechuga, Laura M Analytical And Bioanalytical Chemistry; 2024. 10.1007/s00216-024-05398-3. IF: 3.800
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An α-helical peptide-based plasmonic biosensor for highly specific detection of α-synuclein-toxic oligomers
Juliana de Fátima Giarola; Jaime Santos; M.‐Carmen Estévez; Salvador Ventura; Irantzu Pallarès; Laura M. Lechuga Analytica Chimica Acta; 1304: 342559 - 342559. 2024. 10.1016/j.aca.2024.342559. IF: 5.700
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Chemistry for next-generation diagnostics: Key factors in the development of medical biosensors
Maria Soler; Laura M. Lechuga Mètode. Annual Review; (15) 2024. 10.7203/metode.15.27225.
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Plasmonic biosensors: Towards fully operative detection platforms for biomedical application and its potential for the diagnosis of autoimmune diseases
Juliana de Fátima Giarola; M.‐Carmen Estévez; Laura M. Lechuga Trac Trends In Analytical Chemistry; 176: 117763 - 117763. 2024. 10.1016/j.trac.2024.117763.
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Validation of a plasmonic-based serology biosensor for veterinary diagnosis of COVID-19 in domestic animals
Giarola, Juliana Fatima; Soler, Maria; Estevez, M -Carmen; Tarasova, Anna; Le Poder, Sophie; Wasniewski, Marine; Decaro, Nicola; Lechuga, Laura M Talanta; 271: 125685. 2024. 10.1016/j.talanta.2024.125685. IF: 5.600
2023
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Biomimetic nanoplasmonic sensor for rapid evaluation of neutralizing SARS-CoV-2 monoclonal antibodies as antiviral therapy
Batool, R; Soler, M; Colavita, F; Fabeni, L; Matusali, G; Lechuga, LM Biosensors & Bioelectronics; 226: 115137. 2023. 10.1016/j.bios.2023.115137. IF: 12.600
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Integration of Metal-Organic Polyhedra onto a Nanophotonic Sensor for Real-Time Detection of Nitrogenous Organic Pollutants in Water
Calvo-Lozano, O; Hernández-López, L; Gomez, L; Carné-Sánchez, A; von Baeckmann, C; Lechuga, LM; Maspoch, D Acs Applied Materials & Interfaces; 15 (33): 39523 - 39529. 2023. 10.1021/acsami.3c07213. IF: 9.500
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Using Electrochemical Immunoassay in a Novel Microtiter Plate to Detect Surface Markers of Preeclampsia on Urinary Extracellular Vesicles
Lee, S; Gonzalez-Suarez, AM; Huang, XH; Calvo-Lozano, O; Suvakov, S; Lechuga, LM; Garovic, VD; Stybayeva, G; Revzin, A Acs Sensors; 8 (1): 207 - 217. 2023. 10.1021/acssensors.2c02077. IF: 8.900
2022
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Biochemistry strategies for label-free optical sensor biofunctionalization: advances towards real applicability
Soler M., Lechuga L.M. Analytical and Bioanalytical Chemistry; 414 (18): 5071 - 5085. 2022. 10.1007/s00216-021-03751-4. IF: 4.157
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Coating Bioactive Microcapsules with Tannic Acid Enhances the Phenotype of the Encapsulated Pluripotent Stem Cells
Choi D., Gwon K., Hong H.J., Baskaran H., Calvo-Lozano O., Gonzalez-Suarez A.M., Park K., De Hoyos-Vega J.M., Lechuga L.M., Hong J., Stybayeva G., Revzin A. ACS Applied Materials and Interfaces; 14 (23): 27274 - 27286. 2022. 10.1021/acsami.2c06783.
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Integrated optical bimodal waveguide biosensors: Principles and applications
Torrijos-Morán L., Lisboa B.D., Soler M., Lechuga L.M., García-Rupérez J. Results in Optics; 9 (100285) 2022. 10.1016/j.rio.2022.100285.
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Label-Free Plasmonic Biosensor for Rapid, Quantitative, and Highly Sensitive COVID-19 Serology: Implementation and Clinical Validation
Calvo-Lozano O., Sierra M., Soler M., Estévez M.C., Chiscano-Camón L., Ruiz-Sanmartin A., Ruiz-Rodriguez J.C., Ferrer R., González-López J.J., Esperalba J., Fernández-Naval C., Bueno L., López-Aladid R., Torres A., Fernández-Barat L., Attoumani S., Charrel R., Coutard B., Lechuga L.M. Analytical Chemistry; 94 (2): 975 - 984. 2022. 10.1021/acs.analchem.1c03850. IF: 6.986
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Novel Sensing Algorithm for Linear Read-Out of Bimodal Waveguide Interferometric Biosensors
Bassols-Cornudella B., Ramirez-Priego P., Soler M., Estevez M.-C., Luis-Ravelo H.J.D., Cardenosa-Rubio M., Lechuga L.M. Journal of Lightwave Technology; 40 (1): 237 - 244. 2022. 10.1109/JLT.2021.3118103. IF: 4.142
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One-Step and Real-Time Detection of microRNA-21 i n Human Samples for Lung Cancer Biosensing Diagnosis
Calvo-Lozano, O; Garcia-Aparicio, P; Raduly, LZ; Estevez, MC; Berindan-Neagoe, I; Ferracin, M; Lechuga, LM Analytical Chemistry; 94 (42): 14659 - 14665. 2022. 10.1021/acs.analchem.2c02895. IF: 8.008
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Rapid and direct quantification of the SARS-CoV-2 virus with an ultrasensitive nanobody-based photonic nanosensor
Ruiz-Vega, Gisela; Soler, Maria; Estevez, MCarmen; Ramirez-Priego, Patricia; Pazos, Martalu D.; Noriega, María A.; Margolles, Yago; Francés-Gómez, Clara; Geller, Ron; Matusali, Giulia; Colavita, Francesca; di Caro, Antonino; Casasnovas, José M.; Fernández, Luis Angel; Lechuga, Laura M. Sensors &Amp; Diagnostics; 2022. 10.1039/d2sd00082b.
2021
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COVID-19 biosensing technologies
Merkoçi A., Li C.-Z., Lechuga L.M., Ozcan A. Biosensors and Bioelectronics; 178 (113046) 2021. 10.1016/j.bios.2021.113046. IF: 10.618
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Current trends in spr biosensing of sars-cov-2 entry inhibitors
Mauriz E., Lechuga L.M. Chemosensors; 9 (12, 330) 2021. 10.3390/chemosensors9120330. IF: 3.398
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Design and characterization of high-affinity synthetic peptides as bioreceptors for diagnosis of cutaneous leishmaniasis
Prada Y.A., Soler M., Guzmán F., Castillo J.J., Lechuga L.M., Mejía-Ospino E. Analytical and Bioanalytical Chemistry; 413 (17): 4545 - 4555. 2021. 10.1007/s00216-021-03424-2. IF: 4.157
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Nanophotonic biosensors for point-of-care COVID-19 diagnostics and coronavirus surveillance
Ruiz-Vega G., Soler M., Lechuga L.M. JPhys Photonics; 3 (1, 011002) 2021. 10.1088/2515-7647/abd4ee. IF: 0.000
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Plasmonic biosensors for single-molecule biomedical analysis
Mauriz E., Lechuga L.M. Biosensors; 11 (4, 123) 2021. 10.3390/bios11040123. IF: 5.519
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Principles, technologies, and applications of plasmonic biosensors
Soler M., Lechuga L.M. Journal of Applied Physics; 129 (11, 111102) 2021. 10.1063/5.0042811. IF: 2.546
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Real-time monitoring of fenitrothion in water samples using a silicon nanophotonic biosensor
Ramirez-Priego P., Estévez M.-C., Díaz-Luisravelo H.J., Manclús J.J., Montoya Á., Lechuga L.M. Analytica Chimica Acta; 1152 (338276) 2021. 10.1016/j.aca.2021.338276. IF: 6.558
2020
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A compact SPR biosensor device for the rapid and efficient monitoring of gluten-free diet directly in human urine
Peláez E.C., Estevez M.-C., Domínguez R., Sousa C., Cebolla A., Lechuga L.M. Analytical and Bioanalytical Chemistry; 2020. 10.1007/s00216-020-02616-6. IF: 3.637
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Coherent silicon photonic interferometric biosensor with an inexpensive laser source for sensitive label-free immunoassays
Leuermann J., Stamenkovic V., Ramirez-Priego P., Sánchez-Postigo A., Fernández-Gavela A., Chapman C.A., Bailey R.C., Lechuga L.M., Perez-Inestrosa E., Collado D., Halir R., Molina-Fernández Í. Optics Letters; 45 (24) 2020. 10.1364/OL.411635. IF: 3.714
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Detection and Quantification of HspX Antigen in Sputum Samples Using Plasmonic Biosensing: Toward a Real Point-of-Care (POC) for Tuberculosis Diagnosis
Peláez E.C., Estevez M.C., Mongui A., Menéndez M.-C., Toro C., Herrera-Sandoval O.L., Robledo J., García M.J., Portillo P.D., Lechuga L.M. ACS infectious diseases; 6 (5): 1110 - 1120. 2020. 10.1021/acsinfecdis.9b00502. IF: 4.614
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Fast and accurate pneumocystis pneumonia diagnosis in human samples using a label-free plasmonic biosensor
Calvo-Lozano O., Aviñó A., Friaza V., Medina-Escuela A., Huertas C.S., Calderón E.J., Eritja R., Lechuga L.M. Nanomaterials; 10 (6, 1246): 1 - 18. 2020. 10.3390/NANO10061246. IF: 4.324
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How Nanophotonic Label-Free Biosensors Can Contribute to Rapid and Massive Diagnostics of Respiratory Virus Infections: COVID-19 Case
Soler M., Estevez M.C., Cardenosa-Rubio M., Astua A., Lechuga L.M. ACS Sensors; 5 (9): 2663 - 2678. 2020. 10.1021/acssensors.0c01180. IF: 7.333
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Label-free detection of nosocomial bacteria using a nanophotonic interferometric biosensor
Maldonado J., Estévez M.-C., Fernández-Gavela A., González-López J.J., González-Guerrero A.B., Lechuga L.M. Analyst; 145 (2): 497 - 506. 2020. 10.1039/c9an01485c. IF: 3.978
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Low Limit of Detection Silicon Photonic Sensor with Extremely-Low-Cost Laser Source
Leuermann J., Fernandez-Gavela A., Lechuga L.M., Sanchez-Postigo A., Halir R., Molina-Fernandez I. 2020 IEEE Photonics Conference, IPC 2020 - Proceedings; (9252217) 2020. 10.1109/IPC47351.2020.9252217. IF: 0.000
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Microfluidic cartridge for LAM-based TB poc-diagnostics using silicon photonics sensor
Becker H., Singh M., Lechuga L., Bockstaele R., Anton B., Martens D., Gonzalez-Guerrero A., Vos R., Elamin A., Bienstman P. 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017; : 1269 - 1270. 2020. . IF: 0.000
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Nanophotonic biosensors: Driving personalized medicine
Soler M., Calvo-Lozano O., Carmen Estevez M., Lechuga L.M. Optics and Photonics News; 31 (4): 25 - 31. 2020. 10.1364/OPN.31.4.000024. IF: 0.000
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One-Step Immobilization of Antibodies and DNA on Gold Sensor Surfaces via a Poly-Adenine Oligonucleotide Approach
Huertas C.S., Soler M., Estevez M.-C., Lechuga L.M. Analytical Chemistry; 92 (18): 12596 - 12604. 2020. 10.1021/acs.analchem.0c02619. IF: 6.785
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Optical nanogap antennas as plasmonic biosensors for the detection of miRNA biomarkers
Portela A., Calvo-Lozano O., Estevez M., Medina Escuela A., Lechuga L.M. Journal of Materials Chemistry B; 8 (19): 4310 - 4317. 2020. 10.1039/d0tb00307g. IF: 5.344
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Silicon photonic label free biosensors with coherent readout
Leuermann J., Fernandez-Gavela A., Halir R., Ortega-Monux A., Wanguemert-Perez J.G., Lechuga L.M., Molina-Fernandez I. International Conference on Transparent Optical Networks; 2020-July (9203519) 2020. 10.1109/ICTON51198.2020.9203519. IF: 0.000
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Ultrasensitive label-free detection of unamplified multidrug-resistance bacteria genes with a bimodal waveguide interferometric biosensor
Maldonado J., González-Guerrero A.B., Fernández-Gavela A., González-López J.J., Lechuga L.M. Diagnostics; 10 (10, 845) 2020. 10.3390/diagnostics10100845. IF: 3.110
2019
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Advanced Evanescent-Wave Optical Biosensors for the Detection of Nucleic Acids: An Analytic Perspective
Huertas C.S., Calvo-Lozano O., Mitchell A., Lechuga L.M. Frontiers in Chemistry; 7 (724) 2019. 10.3389/fchem.2019.00724. IF: 3.782
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Advances in nanoplasmonic biosensors for clinical applications
Mauriz E., Dey P., Lechuga L.M. Analyst; 144 (24): 7105 - 7129. 2019. 10.1039/c9an00701f. IF: 4.019
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Aptamer-peptide conjugates as a new strategy to modulate human α-thrombin binding affinity
Aviñó A., Jorge A.F., Huertas C.S., Cova T.F.G.G., Pais A., Lechuga L.M., Eritja R., Fabrega C. Biochimica et Biophysica Acta - General Subjects; 1863 (10): 1619 - 1630. 2019. 10.1016/j.bbagen.2019.06.014. IF: 3.681
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Building of a flexible microfluidic plasmo-nanomechanical biosensor for live cell analysis
Solis-Tinoco V., Marquez S., Quesada-Lopez T., Villarroya F., Homs-Corbera A., Lechuga L.M. Sensors and Actuators, B: Chemical; 291: 48 - 57. 2019. 10.1016/j.snb.2019.04.038. IF: 6.393
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Early sepsis diagnosis via protein and miRNA biomarkers using a novel point-of-care photonic biosensor
Fabri-Faja N., Calvo-Lozano O., Dey P., Terborg R.A., Estevez M.-C., Belushkin A., Yesilköy F., Duempelmann L., Altug H., Pruneri V., Lechuga L.M. Analytica Chimica Acta; 1077: 232 - 242. 2019. 10.1016/j.aca.2019.05.038. IF: 5.256
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Full integration of photonic nanoimmunosensors in portable platforms for on-line monitoring of ocean pollutants
Fernández-Gavela A., Herranz S., Chocarro B., Falke F., Schreuder E., Leeuwis H., Heideman R.G., Lechuga L.M. Sensors and Actuators, B: Chemical; 297 (126758) 2019. 10.1016/j.snb.2019.126758. IF: 6.393
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Label-free Bacteria Quantification in Blood Plasma by a Bioprinted Microarray Based Interferometric Point-of-Care Device
Dey P., Fabri-Faja N., Calvo-Lozano O., Terborg R.A., Belushkin A., Yesilkoy F., Fàbrega A., Ruiz-Rodriguez J.C., Ferrer R., González-López J.J., Estévez M.C., Altug H., Pruneri V., Lechuga L.M. ACS Sensors; 4 (1): 52 - 60. 2019. 10.1021/acssensors.8b00789. IF: 6.944
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Label-Free Nanoplasmonic Biosensing of Cancer Biomarkers for Clinical Diagnosis
Portela A., Peláez E.C., Calvo-Lozano O., Estévez M.C., Lechuga L.M. Methods in Molecular Biology; 2027: 115 - 140. 2019. 10.1007/978-1-4939-9616-2_10.
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Label-free plasmonic biosensors for point-of-care diagnostics: a review
Soler M., Huertas C.S., Lechuga L.M. Expert Review of Molecular Diagnostics; 19 (1): 71 - 81. 2019. 10.1080/14737159.2019.1554435. IF: 3.099
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Label-free, scalable and point-of-care imaging platform for rapid analysis of biomarker
L. Duempelmann, R. A. Terborg, J. Pello, I. Mannelli, F. Yesilkoy, A. A. Belushkin, Y. Jahani, N. Fabri-Faja, P. Dey, O. Calvo-Lozano, M. -. Estevez, A. Fàbrega, J. J. González-López, L. M. Lechuga, H. Altug, and V. Pruneri SPIE Proceedings (Optical Society of America, 2019); Clinical and Preclinical Optical Diagnostics II, V 2019. 10.1117/12.2525878.
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Low-cost and portable UV holographic microscope for high-contrast protein crystal imaging
Daloglu M.U., Ray A., Collazo M.J., Brown C., Tseng D., Chocarro-Ruiz B., Lechuga L.M., Cascio D., Ozcan A. APL Photonics; 4 (3, 030804) 2019. 10.1063/1.5080158. IF: 4.383
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Low-cost vertical taper for highly efficient light in-coupling in bimodal nanointerferometric waveguide biosensors
Daniel Grajales, Adrián Fernández Gavela, Carlos Domínguez, Jose Ramón Sendra, Laura M Lechuga Journal of Physics: Photonics; 1 (2): 25002. 2019. 10.1088/2515-7647/aafebb. IF: 0.000
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Optimization study of bimodal waveguide interferometric biosensors
Grajales D., Lechuga L.M. Proceedings 2015 European Conference on Lasers and Electro-Optics - European Quantum Electronics Conf; 2019. . IF: 0.000
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Optimizing the limit of detection of waveguide-based interferometric biosensor devices
Leuermann J., Fernández-Gavela A., Torres-Cubillo A., Postigo S., Sánchez-Postigo A., Lechuga L.M., Halir R., Molina-Fernández Í. Sensors (Switzerland); 19 (17, 3671) 2019. 10.3390/s19173671. IF: 3.031
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Polymer Based Trimodal Interferometric Sensor
Ramirez J.C., Lechuga L.M., Hernandez Figueroa H.E., Gabrielli L.H. 2019 SBFoton International Optics and Photonics Conference, SBFoton IOPC 2019; (8910220) 2019. 10.1109/SBFoton-IOPC.2019.8910220.
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Preface
Lechuga L., Raptis I., Jorge P., Cusano A. Optics and Laser Technology; 113: 35 - 36. 2019. 10.1016/j.optlastec.2018.12.006. IF: 3.319
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Site-Specific mRNA Cleavage for Selective and Quantitative Profiling of Alternative Splicing with Label-Free Optical Biosensors
Huertas C.S., Bonnal S., Soler M., Escuela A.M., Valcárcel J., Lechuga L.M. Analytical Chemistry; 91 (23): 15138 - 15146. 2019. 10.1021/acs.analchem.9b03898. IF: 6.350
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Trimodal waveguide demonstration and its implementation as a high order mode interferometer for sensing application
Ramirez J.C., Gabrielli L.H., Lechuga L.M., Hernandez-Figueroa H.E. Sensors (Switzerland); 19 (12, 2821) 2019. 10.3390/s19122821. IF: 3.031
2018
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A CO2 optical sensor based on self-assembled metal-organic framework nanoparticles
Chocarro-Ruiz B., Pérez-Carvajal J., Avci C., Calvo-Lozano O., Alonso M.I., Maspoch D., Lechuga L.M. Journal of Materials Chemistry A; 6 (27): 13171 - 13177. 2018. 10.1039/c8ta02767f. IF: 9.931
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A low-cost integrated biosensing platform based on SiN nanophotonics for biomarker detection in urine
Martens D., Ramirez-Priego P., Murib M.S., Elamin A.A., Gonzalez-Guerrero A.B., Stehr M., Jonas F., Anton B., Hlawatsch N., Soetaert P., Vos R., Stassen A., Severi S., Van Roy W., Bockstaele R., Becker H., Singh M., Lechuga L.M., Bienstman P. Analytical Methods; 10 (25): 3066 - 3073. 2018. 10.1039/c8ay00666k. IF: 2.073
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Gold/silver/gold trilayer films on nanostructured polycarbonate substrates for direct and label-free nanoplasmonic biosensing
López-Muñoz G.A., Estévez M.-C., Vázquez-García M., Berenguel-Alonso M., Alonso-Chamarro J., Homs-Corbera A., Lechuga L.M. Journal of Biophotonics; 11 (8, e201800043) 2018. 10.1002/jbio.201800043. IF: 3.768
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Interferometric nanoimmunosensor for label-free and real-time monitoring of Irgarol 1051 in seawater
Chocarro-Ruiz B., Herranz S., Fernández Gavela A., Sanchís J., Farré M., Marco M.P., Lechuga L.M. Biosensors and Bioelectronics; 117: 47 - 52. 2018. 10.1016/j.bios.2018.05.044. IF: 8.173
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Label-Free and Real-Time Detection of Tuberculosis in Human Urine Samples Using a Nanophotonic Point-of-Care Platform
Ramirez-Priego P., Martens D., Elamin A.A., Soetaert P., Van Roy W., Vos R., Anton B., Bockstaele R., Becker H., Singh M., Bienstman P., Lechuga L.M. ACS Sensors; 3 (10): 2079 - 2086. 2018. 10.1021/acssensors.8b00393. IF: 5.711
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Label-free DNA-methylation detection by direct ds-DNA fragment screening using poly-purine hairpins
Huertas C.S., Aviñó A., Kurachi C., Piqué A., Sandoval J., Eritja R., Esteller M., Lechuga L.M. Biosensors and Bioelectronics; 120: 47 - 54. 2018. 10.1016/j.bios.2018.08.027. IF: 8.173
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Nanoplasmonic biosensor device for the monitoring of acenocoumarol therapeutic drug in plasma
Peláez E.C., Estevez M.-C., Portela A., Salvador J.-P., Marco M.-P., Lechuga L.M. Biosensors and Bioelectronics; 119: 149 - 155. 2018. 10.1016/j.bios.2018.08.011. IF: 8.173
2017
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A label-free nanostructured plasmonic biosensor based on Blu-ray discs with integrated microfluidics for sensitive biodetection
López-Muñoz G.A., Estevez M.-C., Peláez-Gutierrez E.C., Homs-Corbera A., García-Hernandez M.C., Imbaud J.I., Lechuga L.M. Biosensors and Bioelectronics; 96: 260 - 267. 2017. 10.1016/j.bios.2017.05.020. IF: 7.780
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An automated optofluidic biosensor platform combining interferometric sensors and injection moulded microfluidics
Szydzik C., Gavela A.F., Herranz S., Roccisano J., Knoerzer M., Thurgood P., Khoshmanesh K., Mitchell A., Lechuga L.M. Lab on a Chip; 17 (16): 2793 - 2804. 2017. 10.1039/c7lc00524e. IF: 6.045
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Analysis of alternative splicing events for cancer diagnosis using a multiplexing nanophotonic biosensor
Huertas C.S., Domínguez-Zotes S., Lechuga L.M. Scientific Reports; 7 ( 41368) 2017. 10.1038/srep41368. IF: 4.259
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Array of Microfluidic Beam Resonators for Density and Viscosity Analysis of Liquids
Marquez S., Álvarez M., Fariña Santana D., Homs-Corbera A., Domínguez C., Lechuga L.M. Journal of Microelectromechanical Systems; 26 (4, 7945266): 749 - 757. 2017. 10.1109/JMEMS.2017.2709944. IF: 2.124
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Asymmetrically coupled resonators for mass sensing
Marquez S., Alvarez M., Plaza J.A., Villanueva L.G., Dominguez C., Lechuga L.M. Applied Physics Letters; 111 (11, 113101) 2017. 10.1063/1.5003023. IF: 3.411
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Cryptophane-cladded interferometric waveguide sensor for aqueous methane detection
Jágerská J., Dullo F.T., Lindecrantz S.M., Börgers J.M., Hansen J.H., Lechuga L.M., Hellesø O.G. Optics InfoBase Conference Papers; Part F43-CLEO_AT 2017 2017. 10.1364/CLEO_AT.2017.AM3B.4. IF: 0.000
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Direct and label-free detection of the human growth hormone in urine by an ultrasensitive bimodal waveguide biosensor
González-Guerrero A.B., Maldonado J., Dante S., Grajales D., Lechuga L.M. Journal of Biophotonics; 10 (1): 61 - 67. 2017. 10.1002/jbio.201600154. IF: 4.328
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Label-free biosensors based on bimodal waveguide (BiMW) interferometers
Herranz S., Gavela A.F., Lechuga L.M. Methods in Molecular Biology; 1571: 161 - 185. 2017. 10.1007/978-1-4939-6848-0_11.
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Nanophotonic interferometric immunosensors for label-free and real-time monitoring of chemical contaminants in marine environment
Chocarro-Ruiz B., Herranz S., Fernández Gavela A., Lechuga L.M. Proceedings of SPIE - The International Society for Optical Engineering; 10215 ( 1021503) 2017. 10.1117/12.2256982. IF: 0.000
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Nanophotonic label-free biosensors for environmental monitoring
Chocarro-Ruiz B., Fernández-Gavela A., Herranz S., Lechuga L.M. Current Opinion in Biotechnology; 45: 175 - 183. 2017. 10.1016/j.copbio.2017.03.016. IF: 9.294
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Preface – European Materials Research Society (E-MRS) Spring Meeting 2016 Symposium M: Silicon compatible materials and integrated devices for photonics and optical sensing
Miritello M., Rebohle L., Lechuga L.M., Maier S. Journal of Luminescence; 191: 87. 2017. 10.1016/j.jlumin.2017.07.001.
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Recent advances in nanoplasmonic biosensors: Applications and lab-on-a-chip integration
Lopez G.A., Estevez M.-C., Soler M., Lechuga L.M. Nanophotonics; 6 (1): 123 - 136. 2017. 10.1515/nanoph-2016-0101. IF: 4.492
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Simple, low-cost and timely optical biosensors for the detection of epigenetics biomarkers: the future of cancer diagnosis
C. S. Huertas and L. M. Lechuga European Medical Journal; 5 (1): 54 - 61. 2017. .
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Species-specific modulation of food-search behavior by respiration and chemosensation in Drosophila larvae
Kim D., Alvarez M., Lechuga L.M., Louis M. eLife; 6 ( e27057) 2017. 10.7554/eLife.27057. IF: 7.725
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The potential of nanophotonic lab-on-chip biosensors for high-value diagnostics
Lechuga L.M. Optics InfoBase Conference Papers; Part F82-CLEO_Europe 2017 2017. .
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Vertical adiabatic taper for efficient in-coupling in nano-interferometric waveguide biosensors
Grajales D., Gavela A.F., Domi´nguez C., Lechuga L.M. Optics InfoBase Conference Papers; Part F82-CLEO_Europe 2017 2017. .
2016
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Fabrication of well-ordered silicon nanopillars embedded in a microchannel: Via metal-assisted chemical etching: A route towards an opto-mechanical biosensor
Solis-Tinoco V., Marquez S., Sepulveda B., Lechuga L.M. RSC Advances; 6 (88): 85666 - 85674. 2016. 10.1039/c6ra15485a. IF: 3.289
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Label-free bimodal waveguide immunosensor for rapid diagnosis of bacterial infections in cirrhotic patients
Maldonado J., González-Guerrero A.B., Domínguez C., Lechuga L.M. Biosensors and Bioelectronics; 85: 310 - 316. 2016. 10.1016/j.bios.2016.04.095. IF: 7.476
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Label-free nanoplasmonic sensing of tumor-associate autoantibodies for early diagnosis of colorectal cancer
Soler M., Estevez M.-C., Villar-Vazquez R., Casal J.I., Lechuga L.M. Analytica Chimica Acta; 930: 31 - 38. 2016. 10.1016/j.aca.2016.04.059. IF: 4.712
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Label-free SPR detection of gluten peptides in urine for non-invasive celiac disease follow-up
Soler M., Estevez M.-C., Moreno M.D.L., Cebolla A., Lechuga L.M. Biosensors and Bioelectronics; 79: 158 - 164. 2016. 10.1016/j.bios.2015.11.097. IF: 7.476
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Last advances in silicon-based optical biosensors
Gavela A.F., García D.G., Ramirez J.C., Lechuga L.M. Sensors (Switzerland); 16 (3, 285) 2016. 10.3390/s16030285. IF: 2.033
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Out-of-plane single-mode photonic microcantilevers for integrated nanomechanical sensing platform
Fariña Santana D., Álvarez M., Márquez S., Domínguez C., Lechuga L.M. Sensors and Actuators, B: Chemical; 232: 60 - 67. 2016. 10.1016/j.snb.2016.03.041. IF: 4.758
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Prospects of optical biosensors for emerging label-free RNA analysis
Carrascosa L.G., Huertas C.S., Lechuga L.M. TrAC - Trends in Analytical Chemistry; 80: 177 - 189. 2016. 10.1016/j.trac.2016.02.018. IF: 7.487
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Quantitative evaluation of alternatively spliced mRNA isoforms by label-free real-time plasmonic sensing
Huertas C.S., Carrascosa L.G., Bonnal S., Valcárcel J., Lechuga L.M. Biosensors and Bioelectronics; 78: 118 - 125. 2016. 10.1016/j.bios.2015.11.023. IF: 7.476
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Sensitive and label-free detection of miRNA-145 by triplex formation
Aviñó A., Huertas C.S., Lechuga L.M., Eritja R. Analytical and Bioanalytical Chemistry; 408 (3): 885 - 893. 2016. 10.1007/s00216-015-9180-6. IF: 3.125
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Towards an integrated optofluidic system for highly sensitive detection of antibiotics in seawater incorporating bimodal waveguide photonic biosensors and complex, active microfluidics
Szydzik C., Gavela A.F., Roccisano J., Herranz De Andrés S., Mitchell A., Lechuga L.M. Proceedings of SPIE - The International Society for Optical Engineering; 10013 (100132C) 2016. 10.1117/12.2242885.
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Towards the design of universal immunosurfaces for SPR-based assays: A review
Mauriz E., García-Fernández M.C., Lechuga L.M. TrAC - Trends in Analytical Chemistry; 79: 191 - 198. 2016. 10.1016/j.trac.2016.02.006. IF: 7.487
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Trends in photonic lab-on-chip interferometric biosensors for point-of-care diagnostics
González-Guerrero A.B., Maldonado J., Herranz S., Lechuga L.M. Analytical Methods; 8 (48): 8380 - 8394. 2016. 10.1039/c6ay02972h. IF: 1.915
2015
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Design of a surface plasmon resonance immunoassay for therapeutic drug monitoring of amikacin
Losoya-Leal A., Estevez M.-C., Martínez-Chapa S.O., Lechuga L.M. Talanta; 141: 253 - 258. 2015. 10.1016/j.talanta.2015.04.009. IF: 3.545
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Highly sensitive dendrimer-based nanoplasmonic biosensor for drug allergy diagnosis
Soler M., Mesa-Antunez P., Estevez M.-C., Ruiz-Sanchez A.J., Otte M.A., Sepulveda B., Collado D., Mayorga C., Torres M.J., Perez-Inestrosa E., Lechuga L.M. Biosensors and Bioelectronics; 66: 115 - 123. 2015. 10.1016/j.bios.2014.10.081. IF: 6.409
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Linear readout of integrated interferometric biosensors using a periodic wavelength modulation
Dante S., Duval D., Fariña D., González-Guerrero A.B., Lechuga L.M. Laser and Photonics Reviews; 9 (2): 248 - 255. 2015. 10.1002/lpor.201400216. IF: 8.008
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Novel nanoplasmonic biosensor integrated in a microfluidic channel
Solis-Tinoco V., Sepulveda B., Lechuga L.M. Proceedings of SPIE - The International Society for Optical Engineering; 9519 ( 95190T) 2015. 10.1117/12.2178990. IF: 0.000
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Numerical study of a high sensitive polymer biosensor using a trimodal waveguide interferometer
Ramirez J.C., Lechuga L.M., Gabrielli L.H., Hernandez-Figueroa H.E. Proceedings 2015 European Conference on Lasers and Electro-Optics - European Quantum Electronics Conf; 2015. . IF: 0.000
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Sensitivity analysis for improving nanomechanical photonic transducers biosensors
Fariña D., Álvarez M., Márquez S., Dominguez C., Lechuga L.M. Journal of Physics D: Applied Physics; 48 (33, 335401) 2015. 10.1088/0022-3727/48/33/335401. IF: 2.721
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Simulation and characterization of hollow microbridge resonators for label-free biosensing
Marquez S., Alvarez M., Farina D., Dominguez C., Lechuga L.M. Progress in Biomedical Optics and Imaging - Proceedings of SPIE; 9518 ( 95180U) 2015. 10.1117/12.2178981. IF: 0.000
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Study of a low-cost trimodal polymer waveguide for interferometric optical biosensors
Ramirez J.C., Lechuga L.M., Gabrielli L.H., Hernandez-Figueroa H.E. Optics Express; 23 (9): 11985 - 11994. 2015. 10.1364/OE.23.011985. IF: 3.488
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Tailored Height Gradients in Vertical Nanowire Arrays via Mechanical and Electronic Modulation of Metal-Assisted Chemical Etching
Otte M.A., Solis-Tinoco V., Prieto P., Borrisé X., Lechuga L.M., González M.U., Sepulveda B. Small; 11 (33): 4201 - 4208. 2015. 10.1002/smll.201500175. IF: 8.368
2014
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Nanoplasmonic biosensors for label-free deciphering of cellular pathways
Huertas C.S., Lechuga L.M. Latin America Optics and Photonics Conference, LAOP 2014; 2014. 10.1364/laop.2014.lth1d.1.
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Optimization study of bimodal waveguide interferometric biosensors
Grajales D., Lechuga L.M. Optics InfoBase Conference Papers; 2014. .
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Optimization study of bimodal waveguide interferometric biosensors
Grajales D., Lechuga L.M. Optics InfoBase Conference Papers; 2014. .
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Point-of-care diagnostics using integrated optical-based interferometric nanobiosensors
Duval D., González-Guerrero A.B., Dante S., Huertas C.S., Maldonado J., Lechuga L.M. Optical Sensors, 2014; 2014. 10.1364/sensors.2014.seth3b.4.
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Wavelength modulated bimodal interferometer for highly sensitive biosensing applications
Dante S., Duval D., González-Guerrero A.B., Fariña D., Domínguez C., Lechuga L.M. Optical Sensors, 2014; 2014. 10.1364/sensors.2014.seth2c.5.
2008
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Biosensing microsystems: fast, label-free, real-time clinical testing
Laura M. Lechuga; Orlando E. Hidalgo Alonso; Kiril Zinoviev; Carlos Dominguez; J. Elizalde SPIE Newsroom; 2008. .