NanoBiosensors and Bioanalytical Applications

Group Leader: Laura M. Lechuga

Laura M. Lechuga

CSIC Research Professor

Group Leader

Prof. Laura M. Lechuga received her PhD in Chemistry from the Universidad Complutense de Madrid (Spain) in 1992. She is Full Professor of the Spanish National Research Council (CSIC) and Head of the Nanobiosensors and Bioanalytical Applications Group at the Catalan Institute of Nanoscience and Nanotechnology (ICN2) in Barcelona (Spain) and at the Networking Biomedical Research Center (CIBER-BBN). She has been Adjunct Professor at The Artic University of Norway (2012-2016) and Distinguished Visiting Professor at University of Campinas (Brazil) (2013- 2017).

The principal focus of her research is the development of novel nanobiosensor devices based on nanoplasmonics and silicon-based photonics principles, including surface biofunctionalization, microfluidics for automatic fluid delivery and complete lab-on-a-chip integration for point-of-care devices. The use of nanobiosensor devices for a wide range of challenging clinical and environmental applications is one of her main objectives.

She has published over 260 articles, book chapters and proceedings, has 8 families of patents, and has presented her work worldwide in more than 360 invited talks. She has co-founded two spin-off companies. Prof. Lechuga is Associate Editor of Analyst (RSC) and has been Associate Editor for other two physics and engineering journals. She is a member of the Scientific Advisory Board of several national and international high-level research centres and has taken part in numerous international evaluation panels.

She has participated in many EU funded projects (some of them as Coordinator) and has been part of EU Evaluation Panels in the 6th, 7th and H2020 Framework Programmes (including ERC- Adv panels).

She has received several prizes and recognitions along her career, such as the Prize of Physics, Innovation and Technology from the Spanish Royal Society of Physics and BBVA Foundation in 2016 or the Fellow of the Optical Society (OSA) Award in 2014.

In 2020 Prof. Laura Lechuga received three prestigious awards: King Jaume I Prize, “Juan de la Cierva” National Research Award and Ada Byron Prize



  • Label-Free Plasmonic Biosensor for Rapid, Quantitative, and Highly Sensitive COVID-19 Serology: Implementation and Clinical Validation

    Calvo-Lozano O., Sierra M., Soler M., Estévez M.C., Chiscano-Camón L., Ruiz-Sanmartin A., Ruiz-Rodriguez J.C., Ferrer R., González-López J.J., Esperalba J., Fernández-Naval C., Bueno L., López-Aladid R., Torres A., Fernández-Barat L., Attoumani S., Charrel R., Coutard B., Lechuga L.M. Analytical Chemistry; 94 (2): 975 - 984. 2022. 10.1021/acs.analchem.1c03850. IF: 6.986

  • Novel Sensing Algorithm for Linear Read-Out of Bimodal Waveguide Interferometric Biosensors

    Bassols-Cornudella B., Ramirez-Priego P., Soler M., Estevez M.-C., Luis-Ravelo H.J.D., Cardenosa-Rubio M., Lechuga L.M. Journal of Lightwave Technology; 40 (1): 237 - 244. 2022. 10.1109/JLT.2021.3118103. IF: 4.142


  • Biochemistry strategies for label-free optical sensor biofunctionalization: advances towards real applicability

    Soler M., Lechuga L.M. Analytical and Bioanalytical Chemistry; 2021. 10.1007/s00216-021-03751-4. IF: 4.157

  • COVID-19 biosensing technologies

    Merkoçi A., Li C.-Z., Lechuga L.M., Ozcan A. Biosensors and Bioelectronics; 178 (113046) 2021. 10.1016/j.bios.2021.113046. IF: 10.618

  • Current trends in spr biosensing of sars-cov-2 entry inhibitors

    Mauriz E., Lechuga L.M. Chemosensors; 9 (12, 330) 2021. 10.3390/chemosensors9120330. IF: 3.398

  • Design and characterization of high-affinity synthetic peptides as bioreceptors for diagnosis of cutaneous leishmaniasis

    Prada Y.A., Soler M., Guzmán F., Castillo J.J., Lechuga L.M., Mejía-Ospino E. Analytical and Bioanalytical Chemistry; 413 (17): 4545 - 4555. 2021. 10.1007/s00216-021-03424-2. IF: 4.157

  • Nanophotonic biosensors for point-of-care COVID-19 diagnostics and coronavirus surveillance

    Ruiz-Vega G., Soler M., Lechuga L.M. JPhys Photonics; 3 (1, 011002) 2021. 10.1088/2515-7647/abd4ee. IF: 0.000

  • Plasmonic biosensors for single-molecule biomedical analysis

    Mauriz E., Lechuga L.M. Biosensors; 11 (4, 123) 2021. 10.3390/bios11040123. IF: 5.519

  • Principles, technologies, and applications of plasmonic biosensors

    Soler M., Lechuga L.M. Journal of Applied Physics; 129 (11, 111102) 2021. 10.1063/5.0042811. IF: 2.546

  • Real-time monitoring of fenitrothion in water samples using a silicon nanophotonic biosensor

    Ramirez-Priego P., Estévez M.-C., Díaz-Luisravelo H.J., Manclús J.J., Montoya Á., Lechuga L.M. Analytica Chimica Acta; 1152 (338276) 2021. 10.1016/j.aca.2021.338276. IF: 6.558


  • A compact SPR biosensor device for the rapid and efficient monitoring of gluten-free diet directly in human urine

    Peláez E.C., Estevez M.-C., Domínguez R., Sousa C., Cebolla A., Lechuga L.M. Analytical and Bioanalytical Chemistry; 2020. 10.1007/s00216-020-02616-6. IF: 3.637

  • Coherent silicon photonic interferometric biosensor with an inexpensive laser source for sensitive label-free immunoassays

    Leuermann J., Stamenkovic V., Ramirez-Priego P., Sánchez-Postigo A., Fernández-Gavela A., Chapman C.A., Bailey R.C., Lechuga L.M., Perez-Inestrosa E., Collado D., Halir R., Molina-Fernández Í. Optics Letters; 45 (24) 2020. 10.1364/OL.411635. IF: 3.714

  • Detection and Quantification of HspX Antigen in Sputum Samples Using Plasmonic Biosensing: Toward a Real Point-of-Care (POC) for Tuberculosis Diagnosis

    Peláez E.C., Estevez M.C., Mongui A., Menéndez M.-C., Toro C., Herrera-Sandoval O.L., Robledo J., García M.J., Portillo P.D., Lechuga L.M. ACS infectious diseases; 6 (5): 1110 - 1120. 2020. 10.1021/acsinfecdis.9b00502. IF: 4.614

  • Fast and accurate pneumocystis pneumonia diagnosis in human samples using a label-free plasmonic biosensor

    Calvo-Lozano O., Aviñó A., Friaza V., Medina-Escuela A., Huertas C.S., Calderón E.J., Eritja R., Lechuga L.M. Nanomaterials; 10 (6, 1246): 1 - 18. 2020. 10.3390/NANO10061246. IF: 4.324

  • How Nanophotonic Label-Free Biosensors Can Contribute to Rapid and Massive Diagnostics of Respiratory Virus Infections: COVID-19 Case

    Soler M., Estevez M.C., Cardenosa-Rubio M., Astua A., Lechuga L.M. ACS Sensors; 5 (9): 2663 - 2678. 2020. 10.1021/acssensors.0c01180. IF: 7.333

  • Label-free detection of nosocomial bacteria using a nanophotonic interferometric biosensor

    Maldonado J., Estévez M.-C., Fernández-Gavela A., González-López J.J., González-Guerrero A.B., Lechuga L.M. Analyst; 145 (2): 497 - 506. 2020. 10.1039/c9an01485c. IF: 3.978

  • Low Limit of Detection Silicon Photonic Sensor with Extremely-Low-Cost Laser Source

    Leuermann J., Fernandez-Gavela A., Lechuga L.M., Sanchez-Postigo A., Halir R., Molina-Fernandez I. 2020 IEEE Photonics Conference, IPC 2020 - Proceedings; (9252217) 2020. 10.1109/IPC47351.2020.9252217. IF: 0.000

  • Nanophotonic biosensors: Driving personalized medicine

    Soler M., Calvo-Lozano O., Carmen Estevez M., Lechuga L.M. Optics and Photonics News; 31 (4): 25 - 31. 2020. 10.1364/OPN.31.4.000024. IF: 0.000

  • One-Step Immobilization of Antibodies and DNA on Gold Sensor Surfaces via a Poly-Adenine Oligonucleotide Approach

    Huertas C.S., Soler M., Estevez M.-C., Lechuga L.M. Analytical Chemistry; 92 (18): 12596 - 12604. 2020. 10.1021/acs.analchem.0c02619. IF: 6.785

  • Optical nanogap antennas as plasmonic biosensors for the detection of miRNA biomarkers

    Portela A., Calvo-Lozano O., Estevez M., Medina Escuela A., Lechuga L.M. Journal of Materials Chemistry B; 8 (19): 4310 - 4317. 2020. 10.1039/d0tb00307g. IF: 5.344

  • Silicon photonic label free biosensors with coherent readout

    Leuermann J., Fernandez-Gavela A., Halir R., Ortega-Monux A., Wanguemert-Perez J.G., Lechuga L.M., Molina-Fernandez I. International Conference on Transparent Optical Networks; 2020-July (9203519) 2020. 10.1109/ICTON51198.2020.9203519. IF: 0.000

  • Ultrasensitive label-free detection of unamplified multidrug-resistance bacteria genes with a bimodal waveguide interferometric biosensor

    Maldonado J., González-Guerrero A.B., Fernández-Gavela A., González-López J.J., Lechuga L.M. Diagnostics; 10 (10, 845) 2020. 10.3390/diagnostics10100845. IF: 3.110


  • Advanced Evanescent-Wave Optical Biosensors for the Detection of Nucleic Acids: An Analytic Perspective

    Huertas C.S., Calvo-Lozano O., Mitchell A., Lechuga L.M. Frontiers in Chemistry; 7 (724) 2019. 10.3389/fchem.2019.00724. IF: 3.782

  • Advances in nanoplasmonic biosensors for clinical applications

    Mauriz E., Dey P., Lechuga L.M. Analyst; 144 (24): 7105 - 7129. 2019. 10.1039/c9an00701f. IF: 4.019

  • Aptamer-peptide conjugates as a new strategy to modulate human α-thrombin binding affinity

    Aviñó A., Jorge A.F., Huertas C.S., Cova T.F.G.G., Pais A., Lechuga L.M., Eritja R., Fabrega C. Biochimica et Biophysica Acta - General Subjects; 1863 (10): 1619 - 1630. 2019. 10.1016/j.bbagen.2019.06.014. IF: 3.681

  • Boosting Cancer Immunotherapies with Optical Biosensor Nanotechnologies

    Maria Soler, Laura M. Lechuga European Medical Journal Oncology; 4 (4): 124 - 132. 2019. noDOI-Soler.

  • Early sepsis diagnosis via protein and miRNA biomarkers using a novel point-of-care photonic biosensor

    Fabri-Faja N., Calvo-Lozano O., Dey P., Terborg R.A., Estevez M.-C., Belushkin A., Yesilköy F., Duempelmann L., Altug H., Pruneri V., Lechuga L.M. Analytica Chimica Acta; 1077: 232 - 242. 2019. 10.1016/j.aca.2019.05.038. IF: 5.256

  • Full integration of photonic nanoimmunosensors in portable platforms for on-line monitoring of ocean pollutants

    Fernández-Gavela A., Herranz S., Chocarro B., Falke F., Schreuder E., Leeuwis H., Heideman R.G., Lechuga L.M. Sensors and Actuators, B: Chemical; 297 (126758) 2019. 10.1016/j.snb.2019.126758. IF: 6.393

  • Label-free Bacteria Quantification in Blood Plasma by a Bioprinted Microarray Based Interferometric Point-of-Care Device

    Dey P., Fabri-Faja N., Calvo-Lozano O., Terborg R.A., Belushkin A., Yesilkoy F., Fàbrega A., Ruiz-Rodriguez J.C., Ferrer R., González-López J.J., Estévez M.C., Altug H., Pruneri V., Lechuga L.M. ACS Sensors; 4 (1): 52 - 60. 2019. 10.1021/acssensors.8b00789. IF: 6.944

  • Label-Free Nanoplasmonic Biosensing of Cancer Biomarkers for Clinical Diagnosis

    Portela A., Peláez E.C., Calvo-Lozano O., Estévez M.C., Lechuga L.M. Methods in Molecular Biology; 2027: 115 - 140. 2019. 10.1007/978-1-4939-9616-2_10.

  • Label-free plasmonic biosensors for point-of-care diagnostics: a review

    Soler M., Huertas C.S., Lechuga L.M. Expert Review of Molecular Diagnostics; 19 (1): 71 - 81. 2019. 10.1080/14737159.2019.1554435. IF: 3.099

  • Lens-free interferometric microscope for point-of-care label-free detection of sepsis biomarkers

    Terborg R.A., Duempelmann L., Pello J., Noyan A., Yesilkoy F., Belushkin A.A., Jahani Y., Fabri-Faja N., Dey P., Calvo-Lozano O., Carmen Estevez M., Fàbrega A., González-López J.J., Lechuga L.M., Altug H., Pruneri V. Frontiers in Optics - Proceedings Frontiers in Optics + Laser Science APS/DLS; 2019. 10.1364/FIO.2019.FM3F.6.

  • Low-cost and portable UV holographic microscope for high-contrast protein crystal imaging

    Daloglu M.U., Ray A., Collazo M.J., Brown C., Tseng D., Chocarro-Ruiz B., Lechuga L.M., Cascio D., Ozcan A. APL Photonics; 4 (3, 030804) 2019. 10.1063/1.5080158. IF: 4.383

  • Low-cost vertical taper for highly efficient light in-coupling in bimodal nanointerferometric waveguide biosensors

    Daniel Grajales, Adrián Fernández Gavela, Carlos Domínguez, Jose Ramón Sendra, Laura M Lechuga Journal of Physics: Photonics; 1 (2): 25002. 2019. 10.1088/2515-7647/aafebb. IF: 0.000

  • Numerical study of a high sensitive polymer biosensor using a trimodal waveguide interferometer

    Ramirez J.C., Lechuga L.M., Gabrielli L.H., Hernandez-Figueroa H.E. Proceedings 2015 European Conference on Lasers and Electro-Optics - European Quantum Electronics Conf; 2019. . IF: 0.000

  • Optimization study of bimodal waveguide interferometric biosensors

    Grajales D., Lechuga L.M. Proceedings 2015 European Conference on Lasers and Electro-Optics - European Quantum Electronics Conf; 2019. . IF: 0.000

  • Optimizing the limit of detection of waveguide-based interferometric biosensor devices

    Leuermann J., Fernández-Gavela A., Torres-Cubillo A., Postigo S., Sánchez-Postigo A., Lechuga L.M., Halir R., Molina-Fernández Í. Sensors (Switzerland); 19 (17, 3671) 2019. 10.3390/s19173671. IF: 3.031

  • Polymer Based Trimodal Interferometric Sensor

    Ramirez J.C., Lechuga L.M., Hernandez Figueroa H.E., Gabrielli L.H. 2019 SBFoton International Optics and Photonics Conference, SBFoton IOPC 2019; (8910220) 2019. 10.1109/SBFoton-IOPC.2019.8910220.

  • Site-Specific mRNA Cleavage for Selective and Quantitative Profiling of Alternative Splicing with Label-Free Optical Biosensors

    Huertas C.S., Bonnal S., Soler M., Escuela A.M., Valcárcel J., Lechuga L.M. Analytical Chemistry; 91 (23): 15138 - 15146. 2019. 10.1021/acs.analchem.9b03898. IF: 6.350

  • Trimodal waveguide demonstration and its implementation as a high order mode interferometer for sensing application

    Ramirez J.C., Gabrielli L.H., Lechuga L.M., Hernandez-Figueroa H.E. Sensors (Switzerland); 19 (12, 2821) 2019. 10.3390/s19122821. IF: 3.031


  • A CO2 optical sensor based on self-assembled metal-organic framework nanoparticles

    Chocarro-Ruiz B., Pérez-Carvajal J., Avci C., Calvo-Lozano O., Alonso M.I., Maspoch D., Lechuga L.M. Journal of Materials Chemistry A; 6 (27): 13171 - 13177. 2018. 10.1039/c8ta02767f. IF: 9.931

  • A low-cost integrated biosensing platform based on SiN nanophotonics for biomarker detection in urine

    Martens D., Ramirez-Priego P., Murib M.S., Elamin A.A., Gonzalez-Guerrero A.B., Stehr M., Jonas F., Anton B., Hlawatsch N., Soetaert P., Vos R., Stassen A., Severi S., Van Roy W., Bockstaele R., Becker H., Singh M., Lechuga L.M., Bienstman P. Analytical Methods; 10 (25): 3066 - 3073. 2018. 10.1039/c8ay00666k. IF: 2.073

  • Gold/silver/gold trilayer films on nanostructured polycarbonate substrates for direct and label-free nanoplasmonic biosensing

    López-Muñoz G.A., Estévez M.-C., Vázquez-García M., Berenguel-Alonso M., Alonso-Chamarro J., Homs-Corbera A., Lechuga L.M. Journal of Biophotonics; 11 (8, e201800043) 2018. 10.1002/jbio.201800043. IF: 3.768

  • Interferometric nanoimmunosensor for label-free and real-time monitoring of Irgarol 1051 in seawater

    Chocarro-Ruiz B., Herranz S., Fernández Gavela A., Sanchís J., Farré M., Marco M.P., Lechuga L.M. Biosensors and Bioelectronics; 117: 47 - 52. 2018. 10.1016/j.bios.2018.05.044. IF: 8.173

  • Label-Free and Real-Time Detection of Tuberculosis in Human Urine Samples Using a Nanophotonic Point-of-Care Platform

    Ramirez-Priego P., Martens D., Elamin A.A., Soetaert P., Van Roy W., Vos R., Anton B., Bockstaele R., Becker H., Singh M., Bienstman P., Lechuga L.M. ACS Sensors; 3 (10): 2079 - 2086. 2018. 10.1021/acssensors.8b00393. IF: 5.711

  • Label-free DNA-methylation detection by direct ds-DNA fragment screening using poly-purine hairpins

    Huertas C.S., Aviñó A., Kurachi C., Piqué A., Sandoval J., Eritja R., Esteller M., Lechuga L.M. Biosensors and Bioelectronics; 120: 47 - 54. 2018. 10.1016/j.bios.2018.08.027. IF: 8.173

  • Nanoplasmonic biosensor device for the monitoring of acenocoumarol therapeutic drug in plasma

    Peláez E.C., Estevez M.-C., Portela A., Salvador J.-P., Marco M.-P., Lechuga L.M. Biosensors and Bioelectronics; 119: 149 - 155. 2018. 10.1016/j.bios.2018.08.011. IF: 8.173


  • A label-free nanostructured plasmonic biosensor based on Blu-ray discs with integrated microfluidics for sensitive biodetection

    López-Muñoz G.A., Estevez M.-C., Peláez-Gutierrez E.C., Homs-Corbera A., García-Hernandez M.C., Imbaud J.I., Lechuga L.M. Biosensors and Bioelectronics; 96: 260 - 267. 2017. 10.1016/j.bios.2017.05.020. IF: 7.780

  • An automated optofluidic biosensor platform combining interferometric sensors and injection moulded microfluidics

    Szydzik C., Gavela A.F., Herranz S., Roccisano J., Knoerzer M., Thurgood P., Khoshmanesh K., Mitchell A., Lechuga L.M. Lab on a Chip; 17 (16): 2793 - 2804. 2017. 10.1039/c7lc00524e. IF: 6.045

  • Analysis of alternative splicing events for cancer diagnosis using a multiplexing nanophotonic biosensor

    Huertas C.S., Domínguez-Zotes S., Lechuga L.M. Scientific Reports; 7 ( 41368) 2017. 10.1038/srep41368. IF: 4.259

  • Array of Microfluidic Beam Resonators for Density and Viscosity Analysis of Liquids

    Marquez S., Álvarez M., Fariña Santana D., Homs-Corbera A., Domínguez C., Lechuga L.M. Journal of Microelectromechanical Systems; 26 (4, 7945266): 749 - 757. 2017. 10.1109/JMEMS.2017.2709944. IF: 2.124

  • Asymmetrically coupled resonators for mass sensing

    Marquez S., Alvarez M., Plaza J.A., Villanueva L.G., Dominguez C., Lechuga L.M. Applied Physics Letters; 111 (11, 113101) 2017. 10.1063/1.5003023. IF: 3.411

  • Cryptophane-cladded interferometric waveguide sensor for aqueous methane detection

    Jágerská J., Dullo F.T., Lindecrantz S.M., Börgers J.M., Hansen J.H., Lechuga L.M., Hellesø O.G. Optics InfoBase Conference Papers; Part F43-CLEO_AT 2017 2017. 10.1364/CLEO_AT.2017.AM3B.4. IF: 0.000

  • Direct and label-free detection of the human growth hormone in urine by an ultrasensitive bimodal waveguide biosensor

    González-Guerrero A.B., Maldonado J., Dante S., Grajales D., Lechuga L.M. Journal of Biophotonics; 10 (1): 61 - 67. 2017. 10.1002/jbio.201600154. IF: 4.328

  • Label-free biosensors based on bimodal waveguide (BiMW) interferometers

    Herranz S., Gavela A.F., Lechuga L.M. Methods in Molecular Biology; 1571: 161 - 185. 2017. 10.1007/978-1-4939-6848-0_11.

  • Nanophotonic interferometric immunosensors for label-free and real-time monitoring of chemical contaminants in marine environment

    Chocarro-Ruiz B., Herranz S., Fernández Gavela A., Lechuga L.M. Proceedings of SPIE - The International Society for Optical Engineering; 10215 ( 1021503) 2017. 10.1117/12.2256982. IF: 0.000

  • Nanophotonic label-free biosensors for environmental monitoring

    Chocarro-Ruiz B., Fernández-Gavela A., Herranz S., Lechuga L.M. Current Opinion in Biotechnology; 45: 175 - 183. 2017. 10.1016/j.copbio.2017.03.016. IF: 9.294

  • Preface – European Materials Research Society (E-MRS) Spring Meeting 2016 Symposium M: Silicon compatible materials and integrated devices for photonics and optical sensing

    Miritello M., Rebohle L., Lechuga L.M., Maier S. Journal of Luminescence; 191: 87. 2017. 10.1016/j.jlumin.2017.07.001.

  • Recent advances in nanoplasmonic biosensors: Applications and lab-on-a-chip integration

    Lopez G.A., Estevez M.-C., Soler M., Lechuga L.M. Nanophotonics; 6 (1): 123 - 136. 2017. 10.1515/nanoph-2016-0101. IF: 4.492

  • Simple, low-cost and timely optical biosensors for the detection of epigenetics biomarkers: the future of cancer diagnosis

    C. S. Huertas and L. M. Lechuga European Medical Journal; 5 (1): 54 - 61. 2017. .

  • Species-specific modulation of food-search behavior by respiration and chemosensation in Drosophila larvae

    Kim D., Alvarez M., Lechuga L.M., Louis M. eLife; 6 ( e27057) 2017. 10.7554/eLife.27057. IF: 7.725

  • The potential of nanophotonic lab-on-chip biosensors for high-value diagnostics

    Lechuga L.M. Optics InfoBase Conference Papers; Part F82-CLEO_Europe 2017 2017. .

  • Vertical adiabatic taper for efficient in-coupling in nano-interferometric waveguide biosensors

    Grajales D., Gavela A.F., Domi´nguez C., Lechuga L.M. Optics InfoBase Conference Papers; Part F82-CLEO_Europe 2017 2017. .


  • Fabrication of well-ordered silicon nanopillars embedded in a microchannel: Via metal-assisted chemical etching: A route towards an opto-mechanical biosensor

    Solis-Tinoco V., Marquez S., Sepulveda B., Lechuga L.M. RSC Advances; 6 (88): 85666 - 85674. 2016. 10.1039/c6ra15485a. IF: 3.289

  • Label-free bimodal waveguide immunosensor for rapid diagnosis of bacterial infections in cirrhotic patients

    Maldonado J., González-Guerrero A.B., Domínguez C., Lechuga L.M. Biosensors and Bioelectronics; 85: 310 - 316. 2016. 10.1016/j.bios.2016.04.095. IF: 7.476

  • Label-free nanoplasmonic sensing of tumor-associate autoantibodies for early diagnosis of colorectal cancer

    Soler M., Estevez M.-C., Villar-Vazquez R., Casal J.I., Lechuga L.M. Analytica Chimica Acta; 930: 31 - 38. 2016. 10.1016/j.aca.2016.04.059. IF: 4.712

  • Label-free SPR detection of gluten peptides in urine for non-invasive celiac disease follow-up

    Soler M., Estevez M.-C., Moreno M.D.L., Cebolla A., Lechuga L.M. Biosensors and Bioelectronics; 79: 158 - 164. 2016. 10.1016/j.bios.2015.11.097. IF: 7.476

  • Last advances in silicon-based optical biosensors

    Gavela A.F., García D.G., Ramirez J.C., Lechuga L.M. Sensors (Switzerland); 16 (3, 285) 2016. 10.3390/s16030285. IF: 2.033

  • Out-of-plane single-mode photonic microcantilevers for integrated nanomechanical sensing platform

    Fariña Santana D., Álvarez M., Márquez S., Domínguez C., Lechuga L.M. Sensors and Actuators, B: Chemical; 232: 60 - 67. 2016. 10.1016/j.snb.2016.03.041. IF: 4.758

  • Prospects of optical biosensors for emerging label-free RNA analysis

    Carrascosa L.G., Huertas C.S., Lechuga L.M. TrAC - Trends in Analytical Chemistry; 80: 177 - 189. 2016. 10.1016/j.trac.2016.02.018. IF: 7.487

  • Quantitative evaluation of alternatively spliced mRNA isoforms by label-free real-time plasmonic sensing

    Huertas C.S., Carrascosa L.G., Bonnal S., Valcárcel J., Lechuga L.M. Biosensors and Bioelectronics; 78: 118 - 125. 2016. 10.1016/j.bios.2015.11.023. IF: 7.476

  • Sensitive and label-free detection of miRNA-145 by triplex formation

    Aviñó A., Huertas C.S., Lechuga L.M., Eritja R. Analytical and Bioanalytical Chemistry; 408 (3): 885 - 893. 2016. 10.1007/s00216-015-9180-6. IF: 3.125

  • Towards an integrated optofluidic system for highly sensitive detection of antibiotics in seawater incorporating bimodal waveguide photonic biosensors and complex, active microfluidics

    Szydzik C., Gavela A.F., Roccisano J., Herranz De Andrés S., Mitchell A., Lechuga L.M. Proceedings of SPIE - The International Society for Optical Engineering; 10013 (100132C) 2016. 10.1117/12.2242885.

  • Towards the design of universal immunosurfaces for SPR-based assays: A review

    Mauriz E., García-Fernández M.C., Lechuga L.M. TrAC - Trends in Analytical Chemistry; 79: 191 - 198. 2016. 10.1016/j.trac.2016.02.006. IF: 7.487

  • Trends in photonic lab-on-chip interferometric biosensors for point-of-care diagnostics

    González-Guerrero A.B., Maldonado J., Herranz S., Lechuga L.M. Analytical Methods; 8 (48): 8380 - 8394. 2016. 10.1039/c6ay02972h. IF: 1.915


  • Design of a surface plasmon resonance immunoassay for therapeutic drug monitoring of amikacin

    Losoya-Leal A., Estevez M.-C., Martínez-Chapa S.O., Lechuga L.M. Talanta; 141: 253 - 258. 2015. 10.1016/j.talanta.2015.04.009. IF: 3.545

  • Highly sensitive dendrimer-based nanoplasmonic biosensor for drug allergy diagnosis

    Soler M., Mesa-Antunez P., Estevez M.-C., Ruiz-Sanchez A.J., Otte M.A., Sepulveda B., Collado D., Mayorga C., Torres M.J., Perez-Inestrosa E., Lechuga L.M. Biosensors and Bioelectronics; 66: 115 - 123. 2015. 10.1016/j.bios.2014.10.081. IF: 6.409

  • Linear readout of integrated interferometric biosensors using a periodic wavelength modulation

    Dante S., Duval D., Fariña D., González-Guerrero A.B., Lechuga L.M. Laser and Photonics Reviews; 9 (2): 248 - 255. 2015. 10.1002/lpor.201400216. IF: 8.008

  • Novel nanoplasmonic biosensor integrated in a microfluidic channel

    Solis-Tinoco V., Sepulveda B., Lechuga L.M. Proceedings of SPIE - The International Society for Optical Engineering; 9519 ( 95190T) 2015. 10.1117/12.2178990. IF: 0.000

  • Sensitivity analysis for improving nanomechanical photonic transducers biosensors

    Fariña D., Álvarez M., Márquez S., Dominguez C., Lechuga L.M. Journal of Physics D: Applied Physics; 48 (33, 335401) 2015. 10.1088/0022-3727/48/33/335401. IF: 2.721

  • Simulation and characterization of hollow microbridge resonators for label-free biosensing

    Marquez S., Alvarez M., Farina D., Dominguez C., Lechuga L.M. Progress in Biomedical Optics and Imaging - Proceedings of SPIE; 9518 ( 95180U) 2015. 10.1117/12.2178981. IF: 0.000

  • Study of a low-cost trimodal polymer waveguide for interferometric optical biosensors

    Ramirez J.C., Lechuga L.M., Gabrielli L.H., Hernandez-Figueroa H.E. Optics Express; 23 (9): 11985 - 11994. 2015. 10.1364/OE.23.011985. IF: 3.488

  • Tailored Height Gradients in Vertical Nanowire Arrays via Mechanical and Electronic Modulation of Metal-Assisted Chemical Etching

    Otte M.A., Solis-Tinoco V., Prieto P., Borrisé X., Lechuga L.M., González M.U., Sepulveda B. Small; 11 (33): 4201 - 4208. 2015. 10.1002/smll.201500175. IF: 8.368


  • Nanoplasmonic biosensors for label-free deciphering of cellular pathways

    Huertas C.S., Lechuga L.M. Latin America Optics and Photonics Conference, LAOP 2014; 2014. 10.1364/laop.2014.lth1d.1.

  • Numerical study of a high sensitive polymer biosensor using a trimodal waveguide interferometer

    Ramirez J.C., Lechuga L.M., Gabrielli L.H., Hernandez-Figueroa H.E. Optics InfoBase Conference Papers; 2014. .

  • Numerical study of a high sensitive polymer biosensor using a trimodal waveguide interferometer

    Ramirez J.C., Lechuga L.M., Gabrielli L.H., Hernandez-Figueroa H.E. Optics InfoBase Conference Papers; 2014. .

  • Optimization study of bimodal waveguide interferometric biosensors

    Grajales D., Lechuga L.M. Optics InfoBase Conference Papers; 2014. .

  • Optimization study of bimodal waveguide interferometric biosensors

    Grajales D., Lechuga L.M. Optics InfoBase Conference Papers; 2014. .

  • Point-of-care diagnostics using integrated optical-based interferometric nanobiosensors

    Duval D., González-Guerrero A.B., Dante S., Huertas C.S., Maldonado J., Lechuga L.M. Optical Sensors, 2014; 2014. 10.1364/sensors.2014.seth3b.4.

  • Wavelength modulated bimodal interferometer for highly sensitive biosensing applications

    Dante S., Duval D., González-Guerrero A.B., Fariña D., Domínguez C., Lechuga L.M. Optical Sensors, 2014; 2014. 10.1364/sensors.2014.seth2c.5.


  • Integrated Optical Devices for Lab-on-a-chip Biosensing Applications.

    M.-Carmen Estevez; Mar Alvarez; Laura M. Lechuga Laser and Photonics Reviews; 2011. 10.1002/Ipor.201100025.


  • Biosensing microsystems: fast, label-free, real-time clinical testing

    Laura M. Lechuga; Orlando E. Hidalgo Alonso; Kiril Zinoviev; Carlos Dominguez; J. Elizalde SPIE Newsroom; 2008. .