Staff directory Andrea Idili

Andrea Idili

Postdoctoral Researcher
Nanobioelectronics and Biosensors



  • Protein-Controlled Actuation of Dynamic Nucleic Acid Networks by Using Synthetic DNA Translators**

    Bertucci A., Porchetta A., Del Grosso E., Patiño T., Idili A., Ricci F. Angewandte Chemie - International Edition; 59 (46): 20577 - 20581. 2020. 10.1002/anie.202008553. IF: 12.959

    Integrating dynamic DNA nanotechnology with protein-controlled actuation will expand our ability to process molecular information. We have developed a strategy to actuate strand displacement reactions using DNA-binding proteins by engineering synthetic DNA translators that convert specific protein-binding events into trigger inputs through a programmed conformational change. We have constructed synthetic DNA networks responsive to two different DNA-binding proteins, TATA-binding protein and Myc-Max, and demonstrated multi-input activation of strand displacement reactions. We achieved protein-controlled regulation of a synthetic RNA and of an enzyme through artificial DNA-based communication, showing the potential of our molecular system in performing further programmable tasks. © 2020 Wiley-VCH GmbH