Staff directory
Daniel Maspoch Comamala
ICREA Research Professor and Group Leader
daniel.maspoch(ELIMINAR)@icn2.cat
Supramolecular NanoChemistry and Materials
- ORCID: 0000-0003-1325-9161
- Google Scholar: Visit
Born in l’Escala (Girona) in 1976. He graduated in chemistry at the Universitat de Girona and obtained his PhD in Materials Science at the Universitat Autònoma de Barcelona & Institut de Ciència de Materials de Barcelona. He then moved to Northwestern University, where he worked as a postdoctoral fellow in the group of professor Chad A. Mirkin.
He moved back to the Institut Català de Nanotecnologia (ICN), now ICN2, thanks to a Ramón y Cajal contract, and he founded the Supramolecular NanoChemistry & Materials Group. Since September 2011, he has been ICREA Research Professor and Group Leader at the ICN2, and in 2014 he was awarded European Research Council (ERC) Consolidator Grant.
Prof Maspoch has authored 80 scientific publications and 5 book chapters, has filed 8 patents and established 14 contracts with private companies, including 1 patent licence agreement and 3 successful transfers of in-house technology for immediate application to consumer products.
Publications
2021
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A three-shell supramolecular complex enables the symmetry-mismatched chemo- and regioselective bis-functionalization of C60
Ubasart E., Borodin O., Fuertes-Espinosa C., Xu Y., García-Simón C., Gómez L., Juanhuix J., Gándara F., Imaz I., Maspoch D., von Delius M., Ribas X. Nature Chemistry; 13 (5): 420 - 427. 2021. 10.1038/s41557-021-00658-6. IF: 24.427
Molecular Russian dolls (matryoshkas) have proven useful for testing the limits of preparative supramolecular chemistry but applications of these architectures to problems in other fields are elusive. Here we report a three-shell, matryoshka-like complex—in which C60 sits inside a cycloparaphenylene nanohoop, which in turn is encapsulated inside a self-assembled nanocapsule—that can be used to address a long-standing challenge in fullerene chemistry, namely the selective formation of a particular fullerene bis-adduct. Spectroscopic evidence indicates that the ternary complex is sufficiently stable in solution for the two outer shells to affect the addition chemistry of the fullerene guest. When the complex is subjected to Bingel cyclopropanation conditions, the exclusive formation of a single trans-3 fullerene bis-adduct was observed in a reaction that typically yields more than a dozen products. The selectivity facilitated by this matryoshka-like approach appears to be a general phenomenon and could be useful for applications where regioisomerically pure C60 bis-adducts have been shown to have superior properties compared with isomer mixtures. [Figure not available: see fulltext.] © 2021, The Author(s), under exclusive licence to Springer Nature Limited.
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Assembly of Colloidal Clusters Driven by the Polyhedral Shape of Metal-Organic Framework Particles
Liu Y., Wang J., Imaz I., Maspoch D. Journal of the American Chemical Society; 143 (33): 12943 - 12947. 2021. 10.1021/jacs.1c05363. IF: 15.419
Control of the assembly of colloidal particles into discrete or higher-dimensional architectures is important for the design of myriad materials, including plasmonic sensing systems and photonic crystals. Here, we report a new approach that uses the polyhedral shape of metal-organic-framework (MOF) particles to direct the assembly of colloidal clusters. This approach is based on controlling the attachment of a single spherical polystyrene particle on each face of a polyhedral particle via colloidal fusion synthesis, so that the polyhedral shape defines the final coordination number, which is equal to the number of faces, and geometry of the assembled colloidal cluster. As a proof of concept, we assembled six-coordinated (6-c) octahedral and 8-c cubic clusters using cubic ZIF-8 and octahedral UiO-66 core particles. Moreover, we extended this approach to synthesize a highly coordinated 12-c cuboctahedral cluster from a rhombic dodecahedral ZIF-8 particle. We anticipate that the synthesized colloidal clusters could be further evolved into spherical core-shell MOF@polystyrene particles under conditions that promote a higher fusion degree, thus expanding the methods available for the synthesis of MOF-polymer composites. ©
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Elucidating pore chemistry within metal-organic frameworksviasingle crystal X-ray diffraction; from fundamental understanding to application
Albalad J., Sumby C.J., Maspoch D., Doonan C.J. CrystEngComm; 23 (11): 2185 - 2195. 2021. 10.1039/d1ce00067e. IF: 3.545
Metal-organic frameworks (MOFs) have made inroads in diverse chemical sectors due to the essentially limitless combination of building units and the ability to post-synthetically modify their pore chemistry at the molecular level. The crystalline nature of MOFs permits the use of single crystal X-ray diffraction (SCXRD) to obtain crystallographic snapshots of these transformations, providing invaluable information into the unorthodox chemistry that MOFs can potentially offer. This highlight article aims to provide the reader with the most recent milestones in the use of SCXRD as a vanguard technique to connect molecular-level pore engineering of MOFs with new application fields hitherto unexplored. © The Royal Society of Chemistry 2021.
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Engineering covalent organic frameworks in the modulation of photocatalytic degradation of pollutants under visible light conditions
Jiménez-Almarza A., López-Magano A., Cano R., Ortín-Rubio B., Díaz-García D., Gomez-Ruiz S., Imaz I., Maspoch D., Mas-Ballesté R., Alemán J. Materials Today Chemistry; 22 (100548) 2021. 10.1016/j.mtchem.2021.100548. IF: 8.301
Mixtures of triphenylamine (TPA) and phenyl phenothiazine (PTH) fragments have been incorporated into a series of extended polyimine structures that have been applied in the photodegradation of pollutants of different nature under visible light irradiation. Results obtained revealed that materials containing PTH as the sole photoactive unit resulted in the most active photocatalytic material in the degradation of polybrominated diphenyl ether-1 and Sudan Red III. In contrast, the covalent organic framework containing only TPA acted as the best photocatalyst for the degradation of Methylene Blue. These different trends are related to the versatility of PTH moiety to trigger both photoredox and energy transfer processes, while TPA is only an effective energy transfer catalyst. © 2021 Elsevier Ltd
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Heterogeneous catalysts with programmable topologies generated by reticulation of organocatalysts into metal-organic frameworks: The case of squaramide
Broto-Ribas A., Vignatti C., Jimenez-Almarza A., Luis-Barrera J., Dolatkhah Z., Gándara F., Imaz I., Mas-Ballesté R., Alemán J., Maspoch D. Nano Research; 14 (2): 458 - 465. 2021. 10.1007/s12274-020-2779-8. IF: 8.897
A well-established strategy to synthesize heterogeneous, metal-organic framework (MOF) catalysts that exhibit nanoconfinement effects, and specific pores with highly-localized catalytic sites, is to use organic linkers containing organocatalytic centers. Here, we report that by combining this linker approach with reticular chemistry, and exploiting three-dimensioanl (3D) MOF-structural data from the Cambridge Structural Database, we have designed four heterogeneous MOF-based catalysts for standard organic transformations. These programmable MOFs are isoreticular versions of pcu IRMOF-16, fcu UiO-68 and pillared-pcu SNU-8X, the three most common topologies of MOFs built from the organic linker p,p’-terphenyldicarboxylic acid (tpdc). To synthesize the four squaramide-based MOFs, we designed and synthesized a linker, 4,4’-((3,4‐dioxocyclobut‐1‐ene‐1,2‐diyl)bis(azanedyil))dibenzoic acid (Sq_tpdc), which is identical in directionality and length to tpdc but which contains organocatalytic squaramide centers. Squaramides were chosen because their immobilization into a framework enhances its reactivity and stability while avoiding any self-quenching phenomena. Therefore, the four MOFs share the same organocatalytic squaramide moiety, but confine it within distinct pore environments. We then evaluated these MOFs as heterogeneous H-bonding catalysts in organic transformations: a Friedel-Crafts alkylation and an epoxide ring-opening. Some of them exhibited good performance in both reactions but all showed distinct catalytic profiles that reflect their structural differences. [Figure not available: see fulltext.]. © 2020, Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature.
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Macroscopic Ultralight Aerogel Monoliths of Imine-based Covalent Organic Frameworks
Martín-Illán J.Á., Rodríguez-San-Miguel D., Castillo O., Beobide G., Perez-Carvajal J., Imaz I., Maspoch D., Zamora F. Angewandte Chemie - International Edition; 60 (25): 13969 - 13977. 2021. 10.1002/anie.202100881. IF: 15.336
The use of covalent organic frameworks (COFs) in practical applications demands shaping them into macroscopic objects, which remains challenging. Herein, we report a simple three-step method to produce COF aerogels, based on sol-gel transition, solvent-exchange, and supercritical CO2 drying, in which 2D imine-based COF sheets link together to form hierarchical porous structures. The resultant COF aerogel monoliths have extremely low densities (ca. 0.02 g cm−3), high porosity (total porosity values of ca. 99 %), and mechanically behave as elastic materials under a moderate strain (<25–35 %) but become plastic under greater strain. Moreover, these COF aerogels maintain the micro- and meso-porosity of their constituent COFs, and show excellent absorption capacity (e.g. toluene uptake: 32 g g−1), with high removal efficiency (ca. 99 %). The same three-step method can be used to create functional composites of these COF aerogels with nanomaterials. © 2021 Wiley-VCH GmbH
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Millimeter-Shaped Metal-Organic Framework/Inorganic Nanoparticle Composite as a New Adsorbent for Home Water-Purification Filters
Boix G., Han X., Imaz I., Maspoch D. ACS Applied Materials and Interfaces; 13 (15): 17835 - 17843. 2021. 10.1021/acsami.1c02940. IF: 9.229
Heavy-metal contamination of water is a global problem with an especially severe impact in countries with old or poorly maintained infrastructure for potable water. An increasingly popular solution for ensuring clean and safe drinking water in homes is the use of adsorption-based water filters, given their affordability, efficacy, and simplicity. Herein, we report the preparation and functional validation of a new adsorbent for home water filters, based on our metal-organic framework (MOF) composite containing UiO-66 and cerium(IV) oxide (CeO2) nanoparticles. We began by preparing CeO2@UiO-66 microbeads and then encapsulating them in porous polyethersulfone (PES) granules to obtain millimeter-scale CeO2@UiO-66@PES granules. Next, we validated these granules as an adsorbent for the removal of metals from water by substituting them for the standard adsorbent (ion-exchange resin spheres) inside a commercially available water pitcher from Brita. We assessed their performance according to the American National Standards Institute (ANSI) guideline 53-2019, "Drinking Water Treatment Units - Health Effects Standard". Remarkably, a pitcher loaded with a combination of our CeO2@UiO-66@PES granules and activated carbon at standard ratios met the target reduction thresholds set by NSF/ANSI 53-2019 for all the metals tested: As(III), As(V), Cd(II), Cr(III), Cr(VI), Cu(II), Hg(II), and Pb(II). Throughout the test, the modified pitcher proved to be robust and stable. We are confident that our findings will bring MOF-based adsorbents one step closer to real-world use. © 2021 American Chemical Society.
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Perspectives for polychlorinated trityl radicals
Ratera I., Vidal-Gancedo J., Maspoch D., Bromley S.T., Crivillers N., Mas-Torrent M. Journal of Materials Chemistry C; 9 (33): 10610 - 10623. 2021. 10.1039/d1tc02196f. IF: 7.393
An organic free radical is a molecule with one or more unpaired electrons. Although most free radicals are highly reactive, chemists have developed a few families of so-called persistent organic radicals with high kinetic stabilities. Polychlorinated trityl radicals, also known as polychlorotriphenylmethyl (PTM) radicals, are particularly chemically stable due to the high steric hindrance provided by the chlorine atoms in ortho positions which protect their single unpaired electron localised on the central carbon atom. In addition to their inherent magnetic spin due to the unpaired electron, PTMs exhibit other appealing properties such as a rich electrochemistry and characteristic optical properties (absorption and emission). Moreover, it has been shown that these properties can be tuned through the preparation of a large library of PTM-based derivatives. Here, we review recent developments employing PTM radicals, which include their implementation in molecular electronic junctions/switches, as building blocks for the preparation of magnetic networks and opto-electronic devices/materials and their exploitation in bio-applications. © 2021 The Royal Society of Chemistry.
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Photoredox Heterobimetallic Dual Catalysis Using Engineered Covalent Organic Frameworks
López-Magano A., Ortín-Rubio B., Imaz I., Maspoch D., Alemán J., Mas-Ballesté R. ACS Catalysis; 11 (19): 12344 - 12354. 2021. 10.1021/acscatal.1c03634. IF: 13.084
The functionalization of an imine-based layered covalent organic framework (COF), containing phenanthroline units as ligands, has allowed the obtention of a heterobimetallated material. Photoactive Ir and Ni fragments were immobilized within the porous structure of the COF, enabling heterogeneous light-mediated Csp3-Csp2cross-couplings. As radical precursors, potassium benzyl- and alkoxy-trifluoroborates, organic silicates, and proline derivatives were employed, which brings out the good versatility ofIr,Ni@Phen-COF. Moreover, in all the studied cases, an enhanced activity and stability have been observed in comparison with analogous homogenous systems. © 2021 American Chemical Society
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Steric Hindrance in Metal Coordination Drives the Separation of Pyridine Regioisomers Using Rhodium(II)-Based Metal–Organic Polyhedra
Hernández-López L., Martínez-Esaín J., Carné-Sánchez A., Grancha T., Faraudo J., Maspoch D. Angewandte Chemie - International Edition; 60 (20): 11406 - 11413. 2021. 10.1002/anie.202100091. IF: 15.336
The physicochemical similarity of isomers makes their chemical separation through conventional techniques energy intensive. Herein, we report that, instead of using traditional encapsulation-driven processes, steric hindrance in metal coordination on the outer surface of RhII-based metal–organic polyhedra (Rh-MOPs) can be used to separate pyridine-based regioisomers via liquid–liquid extraction. Through molecular dynamics simulations and wet experiments, we discovered that the capacity of pyridines to coordinatively bind to Rh-MOPs is determined by the positions of the pyridine substituents relative to the pyridine nitrogen and is influenced by steric hindrance. Thus, we exploited the differential solubility of bound and non-bound pyridine regioisomers to engineer liquid–liquid self-sorting systems. As a proof of concept, we separated four different equimolecular mixtures of regioisomers, including a mixture of the industrially relevant compounds 2-chloropyridine and 3-chloropyridine, isolating highly pure compounds in all cases. © 2021 Wiley-VCH GmbH
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Synthesis of Polycarboxylate Rhodium(II) Metal–Organic Polyhedra (MOPs) and their use as Building Blocks for Highly Connected Metal–Organic Frameworks (MOFs)
Grancha T., Carné-Sánchez A., Zarekarizi F., Hernández-López L., Albalad J., Khobotov A., Guillerm V., Morsali A., Juanhuix J., Gándara F., Imaz I., Maspoch D. Angewandte Chemie - International Edition; 60 (11): 5729 - 5733. 2021. 10.1002/anie.202013839. IF: 15.336
Use of preformed metal-organic polyhedra (MOPs) as supermolecular building blocks (SBBs) for the synthesis of metal-organic frameworks (MOFs) remains underexplored due to lack of robust functionalized MOPs. Herein we report the use of polycarboxylate cuboctahedral RhII-MOPs for constructing highly-connected MOFs. Cuboctahedral MOPs were functionalized with carboxylic acid groups on their 12 vertices or 24 edges through coordinative or covalent post-synthetic routes, respectively. We then used each isolated polycarboxylate RhII-MOP as 12-c cuboctahedral or 24-c rhombicuboctahedral SBBs that, upon linkage with metallic secondary building units (SBUs), afford bimetallic highly-connected MOFs. The assembly of a pre-synthesized 12-c SBB with a 4-c paddle-wheel SBU, and a 24-c SBB with a 3-c triangular CuII SBU gave rise to bimetallic MOFs having ftw (4,12)-c or rht (3,24)-c topologies, respectively. © 2020 Wiley-VCH GmbH
2020
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Antigen-specific immunotherapy combined with a regenerative drug in the treatment of experimental type 1 diabetes
Villalba A., Rodriguez-Fernandez S., Perna-Barrull D., Ampudia R.-M., Gomez-Muñoz L., Pujol-Autonell I., Aguilera E., Risueño R.M., Cano-Sarabia M., Maspoch D., Vázquez F., Vives-Pi M. Scientific Reports; 10 (1, 18927) 2020. 10.1038/s41598-020-76041-1. IF: 3.998
Type 1 diabetes is an autoimmune disease caused by the destruction of the insulin-producing β-cells. To revert type 1 diabetes, the suppression of the autoimmune attack should be combined with a β-cell replacement strategy. It has been previously demonstrated that liraglutide, a glucagon-like peptide-1 receptor agonist, restores β-cell mass in type 1 diabetes, via α-cell transdifferentiation and neogenesis. We report here that treatment with liraglutide does not prevent type 1 diabetes in the spontaneous non-obese diabetic (NOD) mouse model, but it tends to reduce leukocytic islet infiltration. However, in combination with an immunotherapy based on tolerogenic liposomes, it is effective in ameliorating hyperglycaemia in diabetic NOD mice. Importantly, liraglutide is not detrimental for the tolerogenic effect that liposomes exert on dendritic cells from patients with type 1 diabetes in terms of membrane expression of molecules involved in antigen presentation, immunoregulation and activation. Moreover, the in vivo effect of the combined therapy was tested in mice humanised with peripheral blood mononuclear cells from patients with type 1 diabetes, showing no adverse effects in leukocyte subsets. In conclusion, the combination therapy with liraglutide and a liposome-based immunotherapy is a promising candidate strategy for type 1 diabetes. © 2020, The Author(s).
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Biomimetic Synthesis of Sub-20 nm Covalent Organic Frameworks in Water
Franco C., Rodríguez-San-Miguel D., Sorrenti A., Sevim S., Pons R., Platero-Prats A.E., Pavlovic M., Szilágyi I., Ruiz Gonzalez M.L., González-Calbet J.M., Bochicchio D., Pesce L., Pavan G.M., Imaz I., Cano-Sarabia M., Maspoch D., Pané S., De Mello A.J., Zamora F., Puigmartí-Luis J. Journal of the American Chemical Society; 142 (7): 3540 - 3547. 2020. 10.1021/jacs.9b12389. IF: 14.612
Covalent organic frameworks (COFs) are commonly synthesized under harsh conditions yielding unprocessable powders. Control in their crystallization process and growth has been limited to studies conducted in hazardous organic solvents. Herein, we report a one-pot synthetic method that yields stable aqueous colloidal solutions of sub-20 nm crystalline imine-based COF particles at room temperature and ambient pressure. Additionally, through the combination of experimental and computational studies, we investigated the mechanisms and forces underlying the formation of such imine-based COF colloids in water. Further, we show that our method can be used to process the colloidal solution into 2D and 3D COF shapes as well as to generate a COF ink that can be directly printed onto surfaces. These findings should open new vistas in COF chemistry, enabling new application areas. Copyright © 2020 American Chemical Society.
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Dynamic porous coordination polymers built-up from flexible 4,4′-dithiodibenzoate and rigid N-based ligands
Jarrah N., Troyano J., Carné-Sánchez A., Imaz I., Tangestaninejad S., Moghadam M., Maspoch D. Dalton Transactions; 49 (37): 13142 - 13151. 2020. 10.1039/d0dt02411b. IF: 4.174
Herein we report the design, synthesis, structural characterisation and functional testing of a series of Cu(ii) coordination polymers containing flexible 4,4′-dithiodibenzoate ligand (4,4′-DTBA), with or without auxiliary N-donor ligands. Reaction of Cu(ii) with 4,4′-DTBA yielded a 1D coordination polymer (1) based on Cu(ii) paddlewheel units connected by 4,4′-DTBA, to form cyclic loop chains with intramolecular voids that exhibit reversible structural transformations upon subsequent solvent exchange in methanol to afford a new, crystalline, permanently-porous structure (1′). However, when the same reaction was run with pyridine, it formed a porous 2D coordination polymer (2). We have attributed the difference in dimensionality seen in the two products to the coordination of pyridine on the axial site of the Cu(ii) paddle-wheel, which forces flexible 4,4′-DTBA to adopt a different conformation. Reactions in the presence of 4,4′-bipyridine (4,4′-bpy) afforded two new, flexible, 2D coordination polymers (3 4). Lower concentrations of 4,4′-bpy afforded a structure (3) built from 1D chains analogous to those in 1 and connected through 4,4′-bpy linkers coordinated to the axial positions. Interestingly, 3 showed reversible structural transformations triggered by either solvent exchange or thermal treatment, each of which yielded a new crystalline and permanently porous phase (3′). Finally, use of higher concentrations of 4,4′-bpy led to a coordination polymer (4) based on a distorted CuO3N2 trigonal bipyramid, rather than on the Cu(ii) paddlewheel. The connection of these motifs by 4,4′-DTBA resulted in a zig-zag 1D chain connected through 4,4′-bpy ligands to form a porous 2D network. Interestingly, 4 also underwent reversible thermal transformation to yield a microporous coordination polymer (4′). © The Royal Society of Chemistry.
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Enzyme-Powered Porous Micromotors Built from a Hierarchical Micro- And Mesoporous UiO-Type Metal-Organic Framework
Yang Y., Arqué X., Patiño T., Guillerm V., Blersch P.-R., Pérez-Carvajal J., Imaz I., Maspoch D., Sánchez S. Journal of the American Chemical Society; 142 (50): 20962 - 20967. 2020. 10.1021/jacs.0c11061. IF: 14.612
Here, we report the design, synthesis, and functional testing of enzyme-powered porous micromotors built from a metal-organic framework (MOF). We began by subjecting a presynthesized microporous UiO-type MOF to ozonolysis, to confer it with mesopores sufficiently large to adsorb and host the enzyme catalase (size: 6-10 nm). We then encapsulated catalase inside the mesopores, observing that they are hosted in those mesopores located at the subsurface of the MOF crystals. In the presence of H2O2 fuel, MOF motors (or MOFtors) exhibit jet-like propulsion enabled by enzymatic generation of oxygen bubbles. Moreover, thanks to their hierarchical pore system, the MOFtors retain sufficient free space for adsorption of additional targeted species, which we validated by testing a MOFtor for removal of rhodamine B during self-propulsion. © 2020 American Chemical Society.
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Green synthesis of imine-based covalent organic frameworks in water
Martín-Illán J.Á., Rodríguez-San-Miguel D., Rodríguez-San-Miguel D., Franco C., Imaz I., Maspoch D., Maspoch D., Puigmartí-Luis J., Zamora F., Zamora F., Zamora F., Zamora F. Chemical Communications; 56 (49): 6704 - 6707. 2020. 10.1039/d0cc02033h. IF: 5.996
Dynamic covalent bonds have been advantageously used to direct the synthesis of crystalline porous covalent organic frameworks (COFs). Unlike the standard synthetic protocols that involve harsh conditions, this work provides a high-yield "one-pot"green synthesis of imine-based COFs in water. Additionally, this aqueous synthesis can be performed under microwave conditions, considerably reducing the reaction time. © The Royal Society of Chemistry.
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LipoBots: Using Liposomal Vesicles as Protective Shell of Urease-Based Nanomotors
Hortelão A.C., García-Jimeno S., Cano-Sarabia M., Patiño T., Maspoch D., Sanchez S. Advanced Functional Materials; 30 (42, 2002767) 2020. 10.1002/adfm.202002767. IF: 16.836
Developing self-powered nanomotors made of biocompatible and functional components is of paramount importance in future biomedical applications. Herein, the functional features of LipoBots (LBs) composed of a liposomal carrier containing urease enzymes for propulsion, including their protective properties against acidic conditions and their on-demand triggered activation, are reported. Given the functional nature of liposomes, enzymes can be either encapsulated or coated on the surface of the vesicles. The influence of the location of urease on motion dynamics is first studied, finding that the surface-urease LBs undergo self-propulsion whereas the encapsulated-urease LBs do not. However, adding a percolating agent present in the bile salts to the encapsulated-urease LBs triggers active motion. Moreover, it is found that when both types of nanomotors are exposed to a medium of similar pH found in the stomach, the surface-urease LBs lose activity and motion capabilities, while the encapsulated-urease LBs retain activity and mobility. The results for the protection enzyme activity through encapsulation within liposomes and in situ triggering of the motion of LBs upon exposure to bile salts may open new avenues for the use of liposome-based nanomotors in drug delivery, for example, in the gastrointestinal tract, where bile salts are naturally present in the intestine. © 2020 Wiley-VCH GmbH
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MOF-Beads Containing Inorganic Nanoparticles for the Simultaneous Removal of Multiple Heavy Metals from Water
Boix G., Troyano J., Garzón-Tovar L., Camur C., Bermejo N., Yazdi A., Piella J., Bastus N.G., Puntes V.F., Imaz I., Maspoch D. ACS Applied Materials and Interfaces; 12 (9): 10554 - 10562. 2020. 10.1021/acsami.9b23206. IF: 8.758
Pollution of water with heavy metals is a global environmental problem whose impact is especially severe in developing countries. Among water-purification methods, adsorption of heavy metals has proven to be simple, versatile, and cost-effective. However, there is still a need to develop adsorbents with a capacity to remove multiple metal pollutants from the same water sample. Herein, we report the complementary adsorption capacities of metal-organic frameworks (here, UiO-66 and UiO-66-(SH)2) and inorganic nanoparticles (iNPs; here, cerium-oxide NPs) into composite materials. These adsorbents, which are spherical microbeads generated in one step by continuous-flow spray-drying, efficiently and simultaneously remove multiple heavy metals from water, including As(III and V), Cd(II), Cr(III and VI), Cu(II), Pb(II), and Hg(II). We further show that these microbeads can be used as a packing material in a prototype of a continuous-flow water treatment system, in which they retain their metal-removal capacities upon regeneration with a gentle acidic treatment. As proof-of-concept, we evaluated these adsorbents for purification of laboratory water samples prepared to independently recapitulate each of two strongly polluted rivers: the Bone (Indonesia) and Buringanga (Bangladesh) rivers. In both cases, our microbeads reduced the levels of all the metal contaminants to below the corresponding permissible limits established by the World Health Organization (WHO). Moreover, we demonstrated the capacity of these microbeads to lower levels of Cr(VI) in a water sample collected from the Sarno River (Italy). Finally, to create adsorbents that could be magnetically recovered following their use in water purification, we extended our spray-drying technique to simultaneously incorporate two types of iNPs (CeO2 and Fe3O4) into UiO-66-(SH)2, obtaining CeO2/Fe3O4@UiO-66-(SH)2 microbeads that adsorb heavy metals and are magnetically responsive. Copyright © 2020 American Chemical Society.
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Molecular Approach for Engineering Interfacial Interactions in Magnetic/Topological Insulator Heterostructures
Cuxart M.G., Valbuena M.A., Robles R., Moreno C., Bonell F., Sauthier G., Imaz I., Xu H., Nistor C., Barla A., Gargiani P., Valvidares M., Maspoch D., Gambardella P., Valenzuela S.O., Mugarza A. ACS Nano; 14 (5): 6285 - 6294. 2020. 10.1021/acsnano.0c02498. IF: 14.588
Controlling interfacial interactions in magnetic/topological insulator heterostructures is a major challenge for the emergence of novel spin-dependent electronic phenomena. As for any rational design of heterostructures that rely on proximity effects, one should ideally retain the overall properties of each component while tuning interactions at the interface. However, in most inorganic interfaces, interactions are too strong, consequently perturbing, and even quenching, both the magnetic moment and the topological surface states at each side of the interface. Here, we show that these properties can be preserved using ligand chemistry to tune the interaction of magnetic ions with the surface states. By depositing Co-based porphyrin and phthalocyanine monolayers on the surface of Bi2Te3 thin films, robust interfaces are formed that preserve undoped topological surface states as well as the pristine magnetic moment of the divalent Co ions. The selected ligands allow us to tune the interfacial hybridization within this weak interaction regime. These results, which are in stark contrast with the observed suppression of the surface state at the first quintuple layer of Bi2Se3 induced by the interaction with Co phthalocyanines, demonstrate the capability of planar metal-organic molecules to span interactions from the strong to the weak limit. © 2020 American Chemical Society.
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Net-Clipping: An Approach to Deduce the Topology of Metal-Organic Frameworks Built with Zigzag Ligands
Ortín-Rubio B., Ghasempour H., Guillerm V., Morsali A., Juanhuix J., Imaz I., Maspoch D., Maspoch D. Journal of the American Chemical Society; 142 (20): 9135 - 9140. 2020. 10.1021/jacs.0c03404. IF: 14.612
Herein we propose a new approach for deducing the topology of metal-organic frameworks (MOFs) assembled from organic ligands of low symmetry, which we call net-clipping. It is based on the construction of nets by rational deconstruction of edge-transitive nets comprising higher-connected molecular building blocks (MBBs). We have applied net-clipping to predict the topologies of MOFs containing zigzag ligands. To this end, we derived 2-connected (2-c) zigzag ligands from 4-c square-like MBBs by first splitting the 4-c nodes into two 3-c nodes and then clipping their two diagonally connecting groups. We demonstrate that, when this approach is applied to the 17 edge-transitive nets containing square-like 4-c MBBs, net-clipping leads to generation of 10 nets with different underlying topologies. Moreover, we report that literature and experimental research corroborate successful implementation of our approach. As proof-of-concept, we employed net-clipping to form three new MOFs built with zigzag ligands, each of which exhibits the deduced topology. © 2020 American Chemical Society.
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Preclinical evaluation of antigen-specific nanotherapy based on phosphatidylserine-liposomes for type 1 diabetes
Villalba A., Rodriguez-Fernandez S., Ampudia R.-M., Cano-Sarabia M., Perna-Barrull D., Bertran-Cobo C., Ehrenberg C., Maspoch D., Vives-Pi M. Artificial Cells, Nanomedicine and Biotechnology; 48 (1): 77 - 83. 2020. 10.1080/21691401.2019.1699812. IF: 3.343
Type 1 diabetes (T1D) is an autoimmune disease caused by the destruction of insulin-producing cells. Due to the ability of apoptotic cells clearance to induce tolerance, we previously generated liposomes rich in phophatidylserine (PS) –a feature of apoptotic cells– loaded with insulin peptides to mimic apoptotic beta-cells. PS-liposomes arrested autoimmunity in experimental T1D through the induction of tolerance. The aim of this study was to investigate the potential of several peptides from different T1D autoantigens encapsulated in (PS)-liposomes for T1D prevention and to assess its safety. T1D autoantigens (Insulin, C-peptide, GAD65 and IA2) were encapsulated in PS-liposomes. Liposomes were administered to the 'gold-standard' model for the study of autoimmune T1D, the Non-Obese Diabetic mouse, that spontaneously develop the disease. Safety and toxicity of liposomes were also determined. Only PS-liposomes encapsulating insulin peptides decrease T1D incidence in the Non-Obese Diabetic mouse model. Disease prevention correlates with a decrease in the severity of the autoimmune islet destruction driven by leukocytes. PS-liposomes neither showed toxic effect nor secondary complications. Among the here referred autoantigens, insulin peptides are the best candidates to be encapsulated in liposomes, like an artificial apoptotic cell, for the arrest of autoimmunity in T1D in a safe manner. © 2019, © 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
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Spray-Drying Synthesis of MOFs, COFs, and Related Composites
Troyano J., Çamur C., Garzón-Tovar L., Carné-Sánchez A., Imaz I., Maspoch D., Maspoch D. Accounts of Chemical Research; 53 (6): 1206 - 1217. 2020. 10.1021/acs.accounts.0c00133. IF: 20.832
ConspectusMetal-organic frameworks (MOFs) and covalent organic frameworks (COFs) are among the most attractive porous materials today. They exhibit outstanding porosity for countless applications such as gas storage, CO2 capture, gas separation, sensing, drug delivery, and catalysis. Moreover, researchers have recently begun to combine MOFs or COFs with other functional materials to obtain composites that boast the respective strengths, and mitigate the respective weaknesses, of each component, enabling enhanced performance in many of the aforementioned applications. Accordingly, development of methods for fabrication of MOFs, COFs, and related composites is important for facilitating adoption of these materials in industry. One promising synthetic technique is spray-drying, which is already well-integrated in manufacturing processes for diverse sectors. It enables rapid, continuous and scalable production of dry microspherical powders in a single step, leading to lower fabrication costs and shorter production times compared to traditional methods.In this Account, we outline our ongoing work on spray-drying synthesis of crystalline porous MOFs, COFs, and related composites. Versatile and tunable, spray-drying can be adapted to perform reactions involving coordination and covalent chemistry for the synthesis of micrometer spherical beads/superstructures of MOFs and COFs. Likewise, MOF- and COF-based composites can be synthesized using similar conditions as those for pure MOFs or COFs, through the simple introduction of additional functional materials into the feed precursor solution or colloid. Interestingly, spray-drying can also be done in water, thus providing the basis for its use as a scalable green method for industrial fabrication of these materials. To date, spray-drying has already been scaled up for pilot production (kilogram scale) of MOFs. © 2020 American Chemical Society.
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Structural Deterioration of Well-Faceted MOFs upon H2S Exposure and Its Effect in the Adsorption Performance
Reljic S., Broto-Ribas A., Cuadrado-Collados C., Jardim E.O., Maspoch D., Imaz I., Silvestre-Albero J. Chemistry - A European Journal; 26 (71): 17110 - 17119. 2020. 10.1002/chem.202002473. IF: 4.857
The structural deterioration of archetypical, well-faceted metal–organic frameworks (MOFs) has been evaluated upon exposure to an acidic environment (H2S). Experimental results show that the structural damage highly depends on the nature of the hybrid network (e.g., softness of the metal ions, hydrophilic properties, among others) and the crystallographic orientation of the exposed facets. Microscopy images show that HKUST-1 with well-defined octahedral (111) facets is completely deteriorated, ZIF-8 with preferentially exposed (110) facets exhibits a large external deterioration with the development of holes or cavities in the mesoporous range, whereas UiO-66-NH2 with (111) exposed facets, and PCN-250 with (100) facets does not reflect any sign of surface damage. Despite the selectivity in the external deterioration, X-ray diffraction and gas adsorption measurements confirm that indeed all MOFs suffer an important internal deterioration, these effects being more severe for MOFs based on softer cations (e.g., Cu-based HKUST-1 and Fe-based PCN-250). These structural changes have inevitable important effects in the final adsorption performance for CO2 and CH4 at low and high pressures. © 2020 Wiley-VCH GmbH
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Supramolecular Fullerene Sponges as Catalytic Masks for Regioselective Functionalization of C60
Fuertes-Espinosa C., García-Simón C., Pujals M., Garcia-Borràs M., Gómez L., Parella T., Juanhuix J., Imaz I., Maspoch D., Costas M., Ribas X. Chem; 6 (1): 169 - 186. 2020. 10.1016/j.chempr.2019.10.010. IF: 19.375
Isomer-pure poly-functionalized fullerenes are required to boost the development of fullerene chemistry in all fields. On a general basis, multi-adduct mixtures with uncontrolled regioselectivity are obtained, and the use of chromatographic purification is prohibitively costly and time consuming, especially in the production of solar cells. Single-isomer poly-functionalized fullerenes are only accessible via stoichiometric, multistep paths entailing protecting-unprotecting sequences. Herein, a nanocapsule is used as a supramolecular tetragonal prismatic mask to exert full control on the reactivity and the equatorial regioselectivity of Bingel-Hirsch cyclopropanation reactions of a confined C60 guest. Thus, equatorial bis-, tris-, and tetrakis-C60 homo-adducts are exclusively obtained in a stepwise manner. Furthermore, isomer-pure equatorial hetero-tetrakis-adducts or hetero-Th-hexakis-adducts are synthesized at will in one-pot synthesis for the first time. This work provides a synthetically valuable path to produce a plethora of new pure-isomer poly-functionalized C60-based compounds as candidates for testing in solar cell devices and biomedical applications. Video Abstract: The supramolecular mask protocol is a significant step forward for the regioselective functionalization of fullerenes. The exquisite ability to form pure-isomer poly-functionalized C60 adducts, overcoming tedious and non-practical chromatographic separations, allows for their direct testing in solar cell prototypes. Furthermore, the supramolecular mask strategy can be applied to C70 or higher fullerenes, opening a plethora of poly-functionalized fullerene derivatives to be synthesized and tested. Moreover, apart from the nucleophilic cyclopropanations reported herein, the protocol is currently being expanded to Diels-Alder (DA), 1,3-dipolar cycloadditions and PC60BM-type cyclopropanations, thus enabling a variety of regioselective functionalization reactions. This supramolecular mask strategy can help the discovery of the next generation of improved solar cells (organic or perovskite based) or new drug candidates. An unprecedented and straightforward supramolecular mask strategy to prepare exclusively equatorial bis-, tris-, and tetrakis-cyclopropanated-C60 Bingel-Hirsch derivatives is reported. By taking advantage of the high affinity for fullerene of tetragonal prismatic supramolecular cages, a highly stable C60⊂1a·(BArF)8 host-guest complex is submitted to Bingel-Hirsch cyclopropanation reaction conditions. Regioselectivity is strictly dictated by the four cross-shaped apertures of the nanocapsule in a controlled fashion. Moreover, stepwise-cyclopropanated adducts up to tetrakis additions are obtained in excellent yields and purities. © 2019 Elsevier Inc.
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Ultrathin Films of Porous Metal–Organic Polyhedra for Gas Separation
Andrés M.A., Carné-Sánchez A., Sánchez-Laínez J., Roubeau O., Coronas J., Maspoch D., Gascón I. Chemistry - A European Journal; 26 (1): 143 - 147. 2020. 10.1002/chem.201904141. IF: 4.857
Ultrathin films of a robust RhII-based porous metal–organic polyhedra (MOP) have been obtained. Homogeneous and compact monolayer films (ca. 2.5 nm thick) were first formed at the air–water interface, deposited onto different substrates and characterized using spectroscopic methods, scanning transmission electron microscopy and atomic force microscopy. As a proof of concept, the gas separation performance of MOP-supported membranes has also been evaluated. Selective MOP ultrathin films (thickness ca. 60 nm) exhibit remarkable CO2 permeance and CO2/N2 selectivity, demonstrating the great combined potential of MOP and Langmuir-based techniques in separation technologies. © 2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
2019
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Dendritic cells from paediatric patients with type 1 diabetes show altered phagocytosis capacity correlating with disease evolution
S. Rodriguez-Fernandez, M. Murillo, D. Perna-Barrull, A. Villalba, D. Maspoch, J. Bel, M. Vives-Pi Diabetologia; 62 (S224) 2019. noDOI-Rodriguez. IF: 7.518
Autoimmunity against β-cells in type 1 diabetes (T1D) is prompted by defective immunological tolerance, an event in which dendritic cells (DCs) play a crucial role as orchestrators of the immune response. Relying on the inherent ability of apoptotic cell clearance to induce tolerance, we designed a liposomal nanotherapy rich in phophatidylserine (PS) -a characteristic signal of the apoptotic cell membrane-and loaded with insulin to mimic apoptotic β-cells. PS-liposomes administration blunted autoimmunity in experimental T1D through the generation of tolerogenic DCs. Moreover, human DCs from adult patients with T1D were also rendered tolerogenic after PS-liposomes phagocytosis. However, since T1D in children is often more complicated to manage and severe dysglycaemia could impair DCs functionality, our aim was to explore the therapeutic value of PS-liposomes in DCs from paediatric patients (PP) with T1D.
2018
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A CO2 optical sensor based on self-assembled metal-organic framework nanoparticles
Chocarro-Ruiz B., Pérez-Carvajal J., Avci C., Calvo-Lozano O., Alonso M.I., Maspoch D., Lechuga L.M. Journal of Materials Chemistry A; 6 (27): 13171 - 13177. 2018. 10.1039/c8ta02767f. IF: 9.931
The development of devices for sensing and monitoring CO2 levels is crucial for many fields such as food packaging and for human safety indoors. Herein the fabrication of an optical CO2 sensor by integration of a metal-organic framework (MOF) onto bimodal optical waveguides is reported. This sensor is constructed via self-assembly of a transparent film of zeolitic imidazolate framework-8 (ZIF-8) nanoparticles (size: 32 ± 5 nm) on the waveguides. The nanoZIF-8-based sensor exhibits a broad linear response, with limits of detection of 3130 ppm at room temperature and 774 ppm at 278 K. Furthermore, it is robust, selective, fast and reusable, and can be stored under humid conditions with no loss in performance. © The Royal Society of Chemistry 2018.
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A Self-Folding Polymer Film Based on Swelling Metal–Organic Frameworks
Troyano J., Carné-Sánchez A., Pérez-Carvajal J., León-Reina L., Imaz I., Cabeza A., Maspoch D. Angewandte Chemie - International Edition; 57 (47): 15420 - 15424. 2018. 10.1002/anie.201808433. IF: 12.102
Herein, we exploit the well-known swelling behaviour of metal–organic frameworks (MOFs) to create a self-folding polymer film. Namely, we show that incorporating crystals of the flexible MOF MIL-88A into a polyvinylidene difluoride (PVDF) matrix affords a polymer composite film that undergoes reversible shape transformations upon exposure to polar solvents and vapours. Since the self-folding properties of this film correlate directly with the swelling properties of the MIL-88A crystals, it selectively bends to certain solvents and its degree of folding can be controlled by controlling the relative humidity. Moreover, it shows a shape-memory effect at relative humidity values from 60 % to 90 %. As proof of concept, we demonstrate that these composite films can lift cargo and can be used to assemble 3D structures from 2D patterns. Our strategy is a straightforward method for designing autonomous soft materials with folding properties that can be tuned by judicious choice of the constituent flexible MOF. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
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Aqueous production of spherical Zr-MOF beads: Via continuous-flow spray-drying
Avci-Camur C., Troyano J., Pérez-Carvajal J., Legrand A., Farrusseng D., Imaz I., Maspoch D. Green Chemistry; 20 (4): 873 - 878. 2018. 10.1039/c7gc03132g. IF: 8.586
Porous metal-organic frameworks (MOFs) are attracting great attention from industry, thanks to their myriad potential applications in areas such as catalysis and gas storage. Zr-MOFs (also known as UiO-type MOFs) are especially promising, owing to their large surface areas, high chemical versatility and remarkable hydrothermal, chemical and thermal stabilities. However, among the challenges currently precluding the industrial exploitation of MOFs is the lack of green methods for their synthesis. Herein we describe a continuous-flow spray-drying method for the simultaneous synthesis and shaping of spherical MOF microbeads in a mixture of water and acetic acid. We used this approach to build two archetypical Zr-MOFs: UiO-66-NH2 and Zr-fumarate. By tuning the concentration of acetic acid in water, we were able to produce, by a scalable process, UiO-66-NH2 and Zr-fumarate beads with SBET and water-sorption values comparable to the literature values obtained with other methods. © 2018 The Royal Society of Chemistry.
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Boosting Self-Assembly Diversity in the Solid-State by Chiral/Non-Chiral ZnII-Porphyrin Crystallization
Qian W., González-Campo A., Pérez-Rodríguez A., Rodríguez-Hermida S., Imaz I., Wurst K., Maspoch D., Ruiz E., Ocal C., Barrena E., Amabilino D.B., Aliaga-Alcalde N. Chemistry - A European Journal; 24 (49): 12950 - 12960. 2018. 10.1002/chem.201802031. IF: 5.160
A chiral ZnII porphyrin derivative 1 and its achiral analogue 2 were studied in the solid state. Considering the rich molecular recognition of designed metalloporphyrins 1 and 2 and their tendency to crystallize, they were recrystallized from two solvent mixtures (CH2Cl2/CH3OH and CH2Cl2/hexane). As a result, four different crystalline arrangements (1 a,b and 2 a,b, from 0D to 2D) were obtained. Solid-state studies were performed on all the species to analyze the role played by chirality, solvent mixtures, and surfaces (mica and HOPG) in the supramolecular arrangements. By means of combinations of solvents and substrates a variety of microsized species was obtained, from vesicles to flower-shaped arrays, including geometrical microcrystals. Overall, the results emphasize the environmental susceptibility of metalloporphyrins and how this feature must be taken into account in their design. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
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Metal Acetylacetonates as a Source of Metals for Aqueous Synthesis of Metal-Organic Frameworks
Avci-Camur C., Perez-Carvajal J., Imaz I., Maspoch D. ACS Sustainable Chemistry and Engineering; 6 (11): 14554 - 14560. 2018. 10.1021/acssuschemeng.8b03180. IF: 6.140
Demand continues for environmentally sound, high-yielding processes for the large-scale production of metal-organic frameworks (MOFs). Here we describe the use of metal acetylacetonate complexes as an alternative source of metals for the aqueous synthesis of MOFs. We have synthesized several carboxylate-based Zr(IV)-(UiO-66-NH2, Zr-fumarate, UiO-66-(OH)2, UiO-66-COOH and UiO-66-(COOH)2), Fe(III)-(MIL-88A) and Al(III)-(CAU-10) porous MOFs from their corresponding metal acetylacetonates in good yields (typically >85%) and, in some cases, at room temperature. © 2018 American Chemical Society.
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Nano/Micro formulations for bacteriophage delivery
Cortés P., Cano-Sarabia M., Colom J., Otero J., Maspoch D., Llagostera M. Methods in Molecular Biology; 1693: 271 - 283. 2018. 10.1007/978-1-4939-7395-8_20.
Encapsulation methodologies allow the protection of bacteriophages for overcoming critical environmental conditions. Moreover, they improve the stability and the controlled delivery of bacteriophages which is of great innovative value in bacteriophage therapy. Here, two different encapsulation methodologies of bacteriophages are described using two biocompatible materials: a lipid cationic mixture and a combination of alginate with the antacid CaCO3. To perform bacteriophage encapsulation, a purified lysate highly concentrated (around 1010–1011 pfu/mL) is necessary, and to dispose of a specific equipment. Both methodologies have been successfully applied for encapsulating Salmonella bacteriophages with different morphologies. Also, the material employed does not modify the antibacterial action of bacteriophages. Moreover, both technologies can also be adapted to any bacteriophage and possibly to any delivery route for bacteriophage therapy. © Springer Science+Business Media LLC 2018.
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Phosphatidylserine-liposomes promote tolerogenic features on dendritic cells in human type 1 diabetes by apoptotic mimicry
Rodriguez-Fernandez S., Pujol-Autonell I., Brianso F., Perna-Barrull D., Cano-Sarabia M., Garcia-Jimeno S., Villalba A., Sanchez A., Aguilera E., Vazquez F., Verdaguer J., Maspoch D., Vives-Pi M. Frontiers in Immunology; 9 (FEB, 253) 2018. 10.3389/fimmu.2018.00253. IF: 5.511
Type 1 diabetes (T1D) is a metabolic disease caused by the autoimmune destruction of insulin-producing β-cells. With its incidence increasing worldwide, to find a safe approach to permanently cease autoimmunity and allow β-cell recovery has become vital. Relying on the inherent ability of apoptotic cells to induce immunological tolerance, we demonstrated that liposomes mimicking apoptotic β-cells arrested autoimmunity to β-cells and prevented experimental T1D through tolerogenic dendritic cell (DC) generation. These liposomes contained phosphatidylserine (PS)-the main signal of the apoptotic cell membrane-and β-cell autoantigens. To move toward a clinical application, PS-liposomes with optimum size and composition for phagocytosis were loaded with human insulin peptides and tested on DCs from patients with T1D and control age-related subjects. PS accelerated phagocytosis of liposomes with a dynamic typical of apoptotic cell clearance, preserving DCs viability. After PS-liposomes phagocytosis, the expression pattern of molecules involved in efferocytosis, antigen presentation, immunoregulation, and activation in DCs concurred with a tolerogenic functionality, both in patients and control subjects. Furthermore, DCs exposed to PS-liposomes displayed decreased ability to stimulate autologous T cell proliferation. Moreover, transcriptional changes in DCs from patients with T1D after PS-liposomes phagocytosis pointed to an immunoregulatory prolife. Bioinformatics analysis showed 233 differentially expressed genes. Genes involved in antigen presentation were downregulated, whereas genes pertaining to tolerogenic/anti-inflammatory pathways were mostly upregulated. In conclusion, PS-liposomes phagocytosis mimics efferocytosis and leads to phenotypic and functional changes in human DCs, which are accountable for tolerance induction. The herein reported results reinforce the potential of this novel immunotherapy to re-establish immunological tolerance, opening the door to new therapeutic approaches in the field of autoimmunity. © 2018 Rodriguez-Fernandez, Pujol-Autonell, Brianso, Perna-Barrull, Cano-Sarabia, Garcia-Jimeno, Villalba, Sanchez, Aguilera, Vazquez, Verdaguer, Maspoch and Vives-Pi.
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Photothermal Activation of Metal-Organic Frameworks Using a UV-Vis Light Source
Espín J., Garzón-Tovar L., Carné-Sánchez A., Imaz I., Maspoch D. ACS Applied Materials and Interfaces; 10 (11): 9555 - 9562. 2018. 10.1021/acsami.8b00557. IF: 8.097
Metal-organic frameworks (MOFs) usually require meticulous removal of the solvent molecules to unlock their potential porosity. Herein, we report a novel one-step method for activating MOFs based on the photothermal effect induced by directly irradiating them with a UV-vis lamp. The localized light-to-heat conversion produced in the MOF crystals upon irradiation enables a very fast solvent removal, thereby significantly reducing the activation time to as low as 30 min and suppressing the need for time-consuming solvent-exchange procedures and vacuum conditions. This approach is successful for a broad range of MOFs, including HKUST-1, UiO-66-NH2, ZIF-67, CPO-27-M (M = Zn, Ni, and Mg), Fe-MIL-101-NH2, and IRMOF-3, all of which exhibit absorption bands in the light emission range. In addition, we anticipate that this photothermal activation can also be used to activate covalent organic frameworks (COFs). © 2018 American Chemical Society.
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Postsynthetic Selective Ligand Cleavage by Solid-Gas Phase Ozonolysis Fuses Micropores into Mesopores in Metal-Organic Frameworks
Guillerm V., Xu H., Albalad J., Imaz I., Maspoch D. Journal of the American Chemical Society; 140 (44): 15022 - 15030. 2018. 10.1021/jacs.8b09682. IF: 14.357
Herein we report a novel, ozone-based method for postsynthetic generation of mesoporosity in metal-organic frameworks (MOFs). By carefully selecting mixed-ligand Zr-fcu-MOFs based on organic ligand pairs in which one ligand has ozone-cleavable olefin bonds and the other ligand is ozone-resistant, we were able to selectively break the cleavable ligand via ozonolysis to trigger fusion of micropores into mesopores within the MOF framework. This solid-gas phase method is performed at room-temperature, and, depending on the cleavable ligand used, the resultant ligand-fragments can be removed from the ozonated MOF by either washing or sublimation. Compared to the corresponding highly microporous starting MOFs, the highly mesoporous product MOFs exhibit radically distinct gas sorption properties. © 2018 American Chemical Society.
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Purification of Uranium-based Endohedral Metallofullerenes (EMFs) by Selective Supramolecular Encapsulation and Release
Fuertes-Espinosa C., Gómez-Torres A., Morales-Martínez R., Rodríguez-Fortea A., García-Simón C., Gándara F., Imaz I., Juanhuix J., Maspoch D., Poblet J.M., Echegoyen L., Ribas X. Angewandte Chemie - International Edition; 57 (35): 11294 - 11299. 2018. 10.1002/anie.201806140. IF: 12.102
Supramolecular nanocapsule 1⋅(BArF)8 is able to sequentially and selectively entrap recently discovered U2@C80 and unprecedented Sc2CU@C80, simply by soaking crystals of 1⋅(BArF)8 in a toluene solution of arc-produced soot. These species, selectively and stepwise absorbed by 1⋅(BArF)8, are easily released, obtaining highly pure fractions of U2@C80 and Sc2CU@C80 in one step. Sc2CU@C80 represents the first example of a mixed metal actinide-based endohedral metallofullerene (EMF). Remarkably, the host–guest studies revealed that 1⋅(BArF)8 is able to discriminate EMFs with the same carbon cage but with different encapsulated cluster and computational studies provide support for these observations. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
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Reversible Thermochromic Polymeric Thin Films Made of Ultrathin 2D Crystals of Coordination Polymers Based on Copper(I)-Thiophenolates
Troyano J., Castillo O., Martínez J.I., Fernández-Moreira V., Ballesteros Y., Maspoch D., Zamora F., Delgado S. Advanced Functional Materials; 28 (5, 1704040) 2018. 10.1002/adfm.201704040. IF: 13.325
A one-pot reaction between Cu(BF4)2·xH2O and 4-mercaptobenzoic acid in acetone or methanol gives rise to the formation of lamellar microcrystals of two Cu(I)-thiophenolate-based coordination polymers (CPs) with the formulas [CuCT] n (1) (CT = 4-carboxy-thiophenolate) and [CuMCT]n (2) (MCT = 4-methoxycarbonyl-thiophenolate). Both 1 and 2 show a reversible luminescent thermochromic behavior upon cooling, changing their color from pale yellow to green to orange in the case of 1, and from pale orange to green in the case of 2. It is shown that the lamellar character of these crystals, which exhibit micrometer lateral dimensions and sub-micrometer/nanometer thicknesses, allows processing them with an organic polymer such as polyvinylidene difluoride (PVDF) to form thermochromic 1@PVDF and 2@PVDF thin films. These thermal stimuli-responsive thin films are freestanding, free of macroscopic defects, and robust under mechanical bending stress, opening up the possibility to use them in, for example, 2D imaging sensor films. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
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Self-assembly of polyhedral metal-organic framework particles into three-dimensional ordered superstructures
Avci C., Imaz I., Carné-Sánchez A., Pariente J.A., Tasios N., Pérez-Carvajal J., Alonso M.I., Blanco A., Dijkstra M., López C., Maspoch D. Nature Chemistry; 10 (1): 78 - 84. 2018. 10.1038/NCHEM.2875. IF: 26.201
Self-assembly of particles into long-range, three-dimensional, ordered superstructures is crucial for the design of a variety of materials, including plasmonic sensing materials, energy or gas storage systems, catalysts and photonic crystals. Here, we have combined experimental and simulation data to show that truncated rhombic dodecahedral particles of the metal-organic framework (MOF) ZIF-8 can self-assemble into millimetre-sized superstructures with an underlying three-dimensional rhombohedral lattice that behave as photonic crystals. Those superstructures feature a photonic bandgap that can be tuned by controlling the size of the ZIF-8 particles and is also responsive to the adsorption of guest substances in the micropores of the ZIF-8 particles. In addition, superstructures with different lattices can also be assembled by tuning the truncation of ZIF-8 particles, or by using octahedral UiO-66 MOF particles instead. These well-ordered, sub-micrometre-sized superstructures might ultimately facilitate the design of three-dimensional photonic materials for applications in sensing. © 2017 Macmillan Publishers Limited, part of Springer Nature.
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Sequential Deconstruction-Reconstruction of Metal-Organic Frameworks: An Alternative Strategy for Synthesizing (Multi)-Layered ZIF Composites
Avci C., Yazdi A., Tarrés M., Bernoud E., Bastús N.G., Puntes V., Imaz I., Ribas X., Maspoch D. ACS Applied Materials and Interfaces; 10 (28): 23952 - 23960. 2018. 10.1021/acsami.8b05098. IF: 8.097
Here, we report the synthesis of (multi)-layered zeolitic imidazolate framework (ZIF-8/-67) composite particles via a sequential deconstruction-reconstruction process. We show that this process can be applied to construct ZIF-8-on-ZIF-67 composite particles whose cores are the initially etched particles. In addition, we demonstrate that introduction of functional inorganic nanoparticles (INPs) onto the crystal surface of etched particles does not disrupt ZIF particle reconstruction, opening new avenues for designing (multi)-layered ZIF-on-INP-on-ZIF composite particles comprising more than one class of inorganic nanoparticles. In these latter composites, the location of the inorganic nanoparticles inside each single metal-organic framework particle as well as of their separation at the nanoscale (20 nm) is controlled. Preliminary results show that (multi)-layered ZIF-on-INP-on-ZIF composite particles comprising a good sequence of inorganic nanoparticles can potentially catalyze cascade reactions. Copyright © 2018 American Chemical Society.
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Single-Crystal-to-Single-Crystal Postsynthetic Modification of a Metal-Organic Framework via Ozonolysis
Albalad J., Xu H., Gándara F., Haouas M., Martineau-Corcos C., Mas-Ballesté R., Barnett S.A., Juanhuix J., Imaz I., Maspoch D. Journal of the American Chemical Society; 140 (6): 2028 - 2031. 2018. 10.1021/jacs.7b12913. IF: 14.357
We describe solid-gas phase, single-crystal-to-single-crystal, postsynthetic modifications of a metal-organic framework (MOF). Using ozone, we quantitatively transformed the olefin groups of a UiO-66-type MOF into 1,2,4-trioxolane rings, which we then selectively converted into either aldehydes or carboxylic acids. © 2018 American Chemical Society.
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Squaramide-IRMOF-16 Analogue for Catalysis of Solvent-Free, Epoxide Ring-Opening Tandem and Multicomponent Reactions
Vignatti C., Luis-Barrera J., Guillerm V., Imaz I., Mas-Ballesté R., Alemán J., Maspoch D. ChemCatChem; 10 (18): 3995 - 3998. 2018. 10.1002/cctc.201801127. IF: 4.674
Tandem and multicomponent one-pot reactions are highly attractive because they enable synthesis of target molecules in a single reaction vessel. However, they are difficult to control, as they can lead to the formation of many undesired side-products. Herein we report the use of metal-organic framework (MOF) pores decorated with organocatalytic squaramide moieties to confine ring-opening epoxide reactions of diverse substrates. Controlled mono-addition or tandem reactions inside the pores yield 1,2-aminoalcohols or 1,2,2′-aminodialcohols, respectively, in good yields. In addition, this squaramide-functionalised MOF enables catalysis of higher-complexity multicomponent reactions such as the catalytic ring-opening of two different epoxides by a single amine to afford 1,2,2′-aminodialcohols. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
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The photothermal effect in MOFs: Covalent post-synthetic modification of MOFs mediated by UV-Vis light under solvent-free conditions
Espín J., Garzón-Tovar L., Boix G., Imaz I., Maspoch D. Chemical Communications; 54 (33): 4184 - 4187. 2018. 10.1039/c8cc01593g. IF: 6.290
Here, we report the covalent post-synthetic modification (CPSM) of MOFs using the photothermal effect. Specifically, we subjected mixtures of a photothermally active MOF and another reagent to irradiation with a UV-Vis lamp. This caused the MOF to heat up, which in turn caused the other reagent to melt and subsequently react with the functional groups on the walls of the MOF pores. We have exploited this dual function of MOFs as both heater and host for CPSMs to achieve rapid formation of amides from the reaction of representative MOFs (UiO-66-NH2 or MIL-101-NH2-(Al)) with anhydrides under solvent-free conditions. In addition, this approach enables more complex CPSMs in MOFs such as the formation of amides in UiO-66-NH2 by using an aldehyde through a cascade reaction. © 2018 The Royal Society of Chemistry.
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Zigzag Ligands for Transversal Design in Reticular Chemistry: Unveiling New Structural Opportunities for Metal-Organic Frameworks
Guillerm V., Grancha T., Imaz I., Juanhuix J., Maspoch D. Journal of the American Chemical Society; 140 (32): 10153 - 10157. 2018. 10.1021/jacs.8b07050. IF: 14.357
Herein we describe the topological influence of zigzag ligands in the assembly of Zr(IV) metal-organic frameworks (MOFs). Through a transversal design strategy using reticular chemistry, we were able to synthesize a family of isoreticular Zr(IV)-based MOFs exhibiting the bcu - rather than the fcu - topology. Our findings underscore the value of the transversal parameter in organic ligands for dictating MOF architectures. © 2018 American Chemical Society.
2017
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Carborane bis-pyridylalcohols as linkers for coordination polymers: Synthesis, crystal structures, and guest-framework dependent mechanical properties
Tsang M.Y., Rodríguez-Hermida S., Stylianou K.C., Tan F., Negi D., Teixidor F., Viñas C., Choquesillo-Lazarte D., Verdugo-Escamilla C., Guerrero M., Sort J., Juanhuix J., Maspoch D., Planas J.G. Crystal Growth and Design; 17 (2): 846 - 857. 2017. 10.1021/acs.cgd.6b01682. IF: 4.055
We report the synthesis and characterization of six novel coordination polymers (CPs) based on M(II) (M: Zn and Co), di-, tri-, and tetracarboxylate linkers and two novel bis-pyridylalcohol 1,7-bis{(pyridin-n′-yl)methanol}-1,7-dicarba-closo-dodecaboranes (n′ = 3, L1; n′ = 4, L2) ligands. The polycarboxylates are terephthalic acid (H2BDC), 1,3,5-benzenetricarboxylic acid (H3BTB), and 1,2,4,5-Tetrakis(4-carboxyphenyl)benzene (H4TCPB). Structural description of CPs reveals the flexibility of the carborane ligands and their ability to construct extended structures. The CP containing Co(II), BTB, and L2 behaves as a crystalline sponge for a variety of guests, showing a higher affinity for aromatic guest molecules. Single-crystal nanoindentation experiments indicate that a high number of specific interactions between the guests and the CP framework result in a high elastic modulus and hardness values. © 2016 American Chemical Society.
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Characterization of ApoJ-reconstituted high-density lipoprotein (rHDL) nanodisc for the potential treatment of cerebral β-amyloidosis
Fernández-De-Retana S., Cano-Sarabia M., Marazuela P., Sánchez-Quesada J.L., Garcia-Leon A., Montañola A., Montaner J., Maspoch D., Hernández-Guillamon M. Scientific Reports; 7 (1, 14637) 2017. 10.1038/s41598-017-15215-w. IF: 4.259
Cerebral β-amyloidosis is a major feature of Alzheimer's disease (AD), characterized by the accumulation of β-amyloid protein (Aβ) in the brain. Several studies have implicated lipid/lipoprotein metabolism in the regulation of β-amyloidosis. In this regard, HDL (High Density Lipoprotein)-based therapies could ameliorate pathological features associated with AD. As apolipoprotein J (ApoJ) is a natural chaperone that interacts with Aβ, avoiding its aggregation and toxicity, in this study we propose to prepare reconstituted rHDL-rApoJ nanoparticles by assembling phospholipids with recombinant human ApoJ (rApoJ). Hence, rHDL particles were prepared using the cholate dialysis method and characterized by N-PAGE, dynamic light scattering, circular dichroism and electron transmission microscopy. The preparation of rHDL particles showed two-sized populations with discoidal shape. Functionally, rHDL-rApoJ maintained the ability to prevent the Aβ fibrillization and mediated a higher cholesterol efflux from cultured macrophages. Fluorescently-labelled rHDL-rApoJ nanoparticles were intravenously administrated in mice and their distribution over time was determined using an IVIS Xenogen® imager. It was confirmed that rHDL-rApoJ accumulated in the cranial region, especially in old transgenic mice presenting a high cerebral Aβ load. In conclusion, we have standardized a reproducible protocol to produce rHDL-rApoJ nanoparticles, which may be potentially considered as a therapeutic option for β-amyloid-related pathologies. © 2017 The Author(s).
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Composite Salt in Porous Metal-Organic Frameworks for Adsorption Heat Transformation
Garzón-Tovar L., Pérez-Carvajal J., Imaz I., Maspoch D. Advanced Functional Materials; 27 (21, 1606424) 2017. 10.1002/adfm.201606424. IF: 12.124
Adsorptive heat transformation systems such as adsorption thermal batteries and chillers can provide space heating and cooling in a more environmental friendly way. However, their use is still hindered by their relatively poor performances and large sizes due to the limited properties of solid adsorbents. Here, the spray-drying continuous-flow synthesis of a new type of solid adsorbents that results from combining metal-organic frameworks (MOFs), such as UiO-66, and hygroscopic salts, such as CaCl2 has been reported. These adsorbents, commonly named as composite salt in porous matrix (CSPM) materials, allow improving the water uptake capabilities of MOFs while preventing their dissolution in the water adsorbed; a common characteristic of these salts due to the deliquescence effect. It is anticipated that MOF-based CSPMs, in which the percentage of salt can be tuned, are promising candidates for thermal batteries and chillers. In these applications, it is showed that a CSPM made of UiO-66 and CaCl2 (38% w/w) exhibits a heat storage capacity of 367 kJ kg−1, whereas a second CSPM made of UiO-66 and CaCl2 (53% w/w) shows a specific cooling power of 631 W kg−1 and a coefficient of performance of 0.83, comparable to the best solid adsorbents reported so far. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
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Confining Functional Nanoparticles into Colloidal Imine-Based COF Spheres by a Sequential Encapsulation–Crystallization Method
Rodríguez-San-Miguel D., Yazdi A., Guillerm V., Pérez-Carvajal J., Puntes V., Maspoch D., Zamora F. Chemistry - A European Journal; 23 (36): 8623 - 8627. 2017. 10.1002/chem.201702072. IF: 5.317
Here, a two-step method is reported that enables imparting new functionalities to covalent organic frameworks (COFs) by nanoparticle confinement. The direct reaction between 1,3,5-tris(4-aminophenyl)benzene and 1,3,5-benzenetricarbaldehyde in the presence of a variety of metallic/metal-oxide nanoparticles resulted in embedding of the nanoparticles in amorphous and non-porous imine-linked polymer organic spheres (NP@a-1). Post-treatment reactions of NP@a-1 with acetic acid under reflux led to crystalline and porous imine-based COF-hybrid spheres (NP@c-1). Interestingly, Au@c-1 and Pd@c-1 were found to be catalytically active. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
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Continuous One-Step Synthesis of Porous M-XF6-Based Metal-Organic and Hydrogen-Bonded Frameworks
Guillerm V., Garzón-Tovar L., Yazdi A., Imaz I., Juanhuix J., Maspoch D. Chemistry - A European Journal; 23 (28): 6829 - 6835. 2017. 10.1002/chem.201605507. IF: 5.317
Metal-organic frameworks (MOFs) built up from connecting M-XF6 pillars through N-donor ligands are among the most attractive adsorbents and separating agents for CO2 and hydrocarbons today. The continuous, one-step spray-drying synthesis of several members of this isoreticular MOF family varying the anionic pillar (XF6=[SiF6]2− and [TiF6]2−), the N-donor organic ligand (pyrazine and 4,4′-bipyridine) and the metal ion (M=Co, Cu and Zn) is demonstrated here. This synthetic method allows them to be obtained in the form of spherical superstructures assembled from nanosized crystals. As confirmed by CO2 and N2 sorption studies, most of the M-XF6-based MOFs synthesised through spray-drying can be considered “ready-to-use” sorbents as they do not need additional purification and time consuming solvent exchange steps to show comparable porosity and sorption properties with the bulk/single-crystal analogues. Stability tests of nanosized M-SiF6-based MOFs confirm their low stability in most solvents, including water and DMF, highlighting the importance of protecting them once synthesised. Finally, for the first time it was shown that the spray-drying method can also be used to assemble hydrogen-bonded open networks, as evidenced by the synthesis of MPM-1-TIFSIX. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
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Core-shell Au/CeO2 nanoparticles supported in UiO-66 beads exhibiting full CO conversion at 100 °c
Yazdi A., Abo Markeb A., Garzón-Tovar L., Patarroyo J., Moral-Vico J., Alonso A., Sánchez A., Bastus N., Imaz I., Font X., Puntes V., Maspoch D. Journal of Materials Chemistry A; 5 (27): 13966 - 13970. 2017. 10.1039/c7ta03006a. IF: 8.867
Hybrid core-shell Au/CeO2 nanoparticles (NPs) dispersed in UiO-66 shaped into microspherical beads are created using the spray-drying continuous-flow method. The combined catalytic properties of nanocrystalline CeO2 and Au in a single particle and the support and protective function of porous UiO-66 beads make the resulting composites show good performances as catalysts for CO oxidation (T50 = 72 °C; T100 = 100 °C) and recyclability. © 2017 The Royal Society of Chemistry.
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Leucine zipper motif inspiration: A two-dimensional leucine Velcro-like array in peptide coordination polymers generates hydrophobicity
Rodríguez-Hermida S., Evangelio E., Rubio-Martínez M., Imaz I., Verdaguer A., Juanhuix J., Maspoch D. Dalton Transactions; 46 (34): 11166 - 11170. 2017. 10.1039/c7dt02153d. IF: 4.029
Here, we show that the well-known hydrophobic leucine (Leu) zipper motif (also known as the coiled-coil or Leu scissors motif), typically found in proteins, can be used as a source of inspiration in coordination polymers built from Leu-containing dipeptides or tripeptides. We demonstrate that this motif can be extended to form Velcro-like layers of Leu, and that the hydrophobicity of these layers is transferred to coordination polymers, thereby enabling the development of a new type of hydrophobic materials. © 2017 The Royal Society of Chemistry.
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Liposome-based immunotherapy against autoimmune diseases: Therapeutic effect on multiple sclerosis
Pujol-Autonell I., Mansilla M.-J., Rodriguez-Fernandez S., Cano-Sarabia M., Navarro-Barriuso J., Ampudia R.-M., Rius A., Garcia-Jimeno S., Perna-Barrull D., Caceres E.M., Maspoch D., Vives-Pi M. Nanomedicine; 12 (11): 1231 - 1242. 2017. 10.2217/nnm-2016-0410. IF: 4.727
Based on the ability of apoptosis to induce immunological tolerance, liposomes were generated mimicking apoptotic cells, and they arrest autoimmunity in Type 1 diabetes. Our aim was to validate the immunotherapy in other autoimmune disease: multiple sclerosis. Materials & methods: Phosphatidylserine-rich liposomes were loaded with disease-specific autoantigen. Therapeutic capability of liposomes was assessed in vitro and in vivo. Results: Liposomes induced a tolerogenic phenotype in dendritic cells, and arrested autoimmunity, thus decreasing the incidence, delaying the onset and reducing the severity of experimental disease, correlating with an increase in a probably regulatory CD25+ FoxP3- CD4+ T-cell subset. Conclusion: This is the first work that confirms phosphatidylserine-liposomes as a powerful tool to arrest multiple sclerosis, demonstrating its relevance for clinical application. © 2017 Future Medicine Ltd.
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Microencapsulation with alginate/CaCO 3: A strategy for improved phage therapy
Colom J., Cano-Sarabia M., Otero J., Aríñez-Soriano J., Cortés P., Maspoch D., Llagostera M. Scientific Reports; 7 ( 41441) 2017. 10.1038/srep41441. IF: 4.259
Bacteriophages are promising therapeutic agents that can be applied to different stages of the commercial food chain. In this sense, bacteriophages can be orally administered to farm animals to protect them against intestinal pathogens. However, the low pH of the stomach, the activities of bile and intestinal tract enzymes limit the efficacy of the phages. This study demonstrates the utility of an alginate/CaCO3 encapsulation method suitable for bacteriophages with different morphologies and to yield encapsulation efficacies of ∼100%. For the first time, a cocktail of three alginate/CaCO3-encapsulated bacteriophages was administered as oral therapy to commercial broilers infected with Salmonella under farm-like conditions. Encapsulation protects the bacteriophages against their destruction by the gastric juice. Phage release from capsules incubated in simulated intestinal fluid was also demonstrated, whereas encapsulation ensured sufficient intestinal retention of the phages. Moreover, the small size of the capsules (125-150 μm) enables their use in oral therapy and other applications in phage therapy. This study evidenced that a cocktail of the three alginate/CaCO3-encapsulated bacteriophages had a greater and more durable efficacy than a cocktail of the corresponding non-encapsulated phages in as therapy in broilers against Salmonella, one of the most common foodborne pathogen. © 2017 The Author(s).
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New synthetic routes towards MOF production at scale
Rubio-Martinez M., Avci-Camur C., Thornton A.W., Imaz I., Maspoch D., Hill M.R. Chemical Society Reviews; 46 (11): 3453 - 3480. 2017. 10.1039/c7cs00109f. IF: 38.618
The potential commercial applications for metal organic frameworks (MOFs) are tantalizing. To address the opportunity, many novel approaches for their synthesis have been developed recently. These strategies present a critical step towards harnessing the myriad of potential applications of MOFs by enabling larger scale production and hence real-world applications. This review provides an up-to-date survey (212 references) of the most promising novel synthetic routes, i.e., electrochemical, microwave, mechanochemical, spray drying and flow chemistry synthesis. Additionally, the essential topic of downstream processes, especially for large scale synthesis, is critically reviewed. Lastly we present the current state of MOF commercialization with direct feedback from commercial players. © The Royal Society of Chemistry 2017.
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Spray drying for making covalent chemistry II: Synthesis of covalent-organic framework superstructures and related composites
Garzón-Tovar L., Avci-Camur C., Rodríguez-San-Miguel D., Imaz I., Zamora F., Maspoch D. Chemical Communications; 53 (82): 11372 - 11375. 2017. 10.1039/c7cc07052g. IF: 6.319
Here we report a method that combines the spray-drying technique with a dynamic covalent chemistry process to synthesize zero-dimensional, spherical and microscale superstructures made from the assembly of imine-based COF nanocrystals. This methodology also enables the integration of other functional materials into these superstructures forming COF-based composites. © 2017 The Royal Society of Chemistry.
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Spray drying for making covalent chemistry: Postsynthetic modification of metal-organic frameworks
Garzón-Tovar L., Rodríguez-Hermida S., Imaz I., Maspoch D. Journal of the American Chemical Society; 139 (2): 897 - 903. 2017. 10.1021/jacs.6b11240. IF: 13.858
Covalent postsynthetic modification (PSM) of metal-organic frameworks (MOFs) has attracted much attention due to the possibility of tailoring the properties of these porous materials. Schiff-base condensation betwecn an amine and an aldehyde is one of the most common reactions in the PSM of MOFs. Here, we report the use of the spray drying technique to perform this class of organic reactions, either betwecn discrete organic molecules or on the pore surfaces of MOFs, in a very fast (1-2 s) and continuous way. Using spray drying, we show the PSM of two MOFs, the amine-terminated UiO-66-NH2 and the aldehyde-terminated ZIF-90, achieving conversion efficiencies up to 20 and 42%, respectively. Moreover, we demonstrate that it can also be used to postsynthetically cross-link the aldehyde groups of ZIF-90 using a diamine molecule with a conversion efficiency of 70%. © 2017 American Chemical Society.
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Systematic study of the impact of MOF densification into tablets on textural and mechanical properties
Dhainaut J., Avci-Camur C., Troyano J., Legrand A., Canivet J., Imaz I., Maspoch D., Reinsch H., Farrusseng D. CrystEngComm; 19 (29): 4211 - 4218. 2017. 10.1039/c7ce00338b. IF: 3.474
Four different metal-organic framework powders (UiO-66, UiO-66-NH2, UiO-67, and HKUST-1) were shaped into tablets. The effect of the applied pressure on porous properties, mechanical resistance and tablet bulk density is reported. We observe a linear relationship between densification and tensile strength for all four studied MOFs, with the slope being MOF-dependent. We also report conditions for improving significantly the volumetric uptake. Finally, we evaluated our tablets' stability over time in the presence of moisture. © 2017 The Royal Society of Chemistry.
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Tuning the Endocytosis Mechanism of Zr-Based Metal-Organic Frameworks through Linker Functionalization
Orellana-Tavra C., Haddad S., Marshall R.J., Abánades Lázaro I., Boix G., Imaz I., Maspoch D., Forgan R.S., Fairen-Jimenez D. ACS Applied Materials and Interfaces; 9 (41): 35516 - 35525. 2017. 10.1021/acsami.7b07342. IF: 7.504
A critical bottleneck for the use of metal-organic frameworks (MOFs) as drug delivery systems has been allowing them to reach their intracellular targets without being degraded in the acidic environment of the lysosomes. Cells take up particles by endocytosis through multiple biochemical pathways, and the fate of these particles depends on these routes of entry. Here, we show the effect of functional group incorporation into a series of Zr-based MOFs on their endocytosis mechanisms, allowing us to design an efficient drug delivery system. In particular, naphthalene-2,6-dicarboxylic acid and 4,4′-biphenyldicarboxylic acid ligands promote entry through the caveolin-pathway, allowing the particles to avoid lysosomal degradation and be delivered into the cytosol and enhancing their therapeutic activity when loaded with drugs. © 2017 American Chemical Society.
2016
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A First Cyclodextrin-Transition Metal Coordination Polymer
Xu H., Rodríguez-Hermida S., Pérez-Carvajal J., Juanhuix J., Imaz I., Maspoch D. Crystal Growth and Design; 16 (10): 5598 - 5602. 2016. 10.1021/acs.cgd.6b01115. IF: 4.425
The synthesis, X-ray crystallographic structure, and water uptake measurements of the first coordination polymer made of a cyclodextrin and a transition metal ion (in this case, Cu2+) are shown. This coordination polymer is made by connecting paddle-wheel Cu2+ units through a γ-cyclodextrin functionalized with eight carboxylate groups, is stable in water, and shows selective water-induced reversible structural transformations. © 2016 American Chemical Society.
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Application of metal and metal oxide nanoparticles at MOFs
Falcaro P., Ricco R., Yazdi A., Imaz I., Furukawa S., Maspoch D., Ameloot R., Evans J.D., Doonan C.J. Coordination Chemistry Reviews; 307: 237 - 254. 2016. 10.1016/j.ccr.2015.08.002. IF: 12.994
Composites based on Metal-Organic Frameworks (MOFs) are an emerging class of porous materials that have been shown to possess unique functional properties. Nanoparticles at MOFs composites combine the tailorable porosity of MOFs with the versatile functionality of metal or metaloxide nanoparticles. A wide range of nanoparticles at MOFs have been synthesised and their performance characteristics assessed in molecular adsorption and separation, catalysis, sensing, optics, sequestration of pollutants, drug delivery, and renewable energy. This review covers the main research areas where nanoparticles at MOFs have been strategically applied and highlights the scientific challenges to be considered for their continuing development. © 2015 Published by Elsevier B.V.
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Charge effect of a liposomal delivery system encapsulating simvastatin to treat experimental ischemic stroke in rats
Campos-Martorell M., Cano-Sarabia M., Simats A., Hernández-Guillamon M., Rosell A., Maspoch D., Montaner J. International Journal of Nanomedicine; 11: 3035 - 3048. 2016. 10.2147/IJN.S107292. IF: 4.320
Background and aims: Although the beneficial effects of statins on stroke have been widely demonstrated both in experimental studies and in clinical trials, the aim of this study is to prepare and characterize a new liposomal delivery system that encapsulates simvastatin to improve its delivery into the brain. Materials and methods: In order to select the optimal liposome lipid composition with the highest capacity to reach the brain, male Wistar rats were submitted to sham or transitory middle cerebral arterial occlusion (MCAOt) surgery and treated (intravenous [IV]) with fluorescent-labeled liposomes with different net surface charges. Ninety minutes after the administration of liposomes, the brain, blood, liver, lungs, spleen, and kidneys were evaluated ex vivo using the Xenogen IVIS® Spectrum imaging system to detect the load of fluorescent liposomes. In a second substudy, simvastatin was assessed upon reaching the brain, comparing free and encapsulated simvastatin (IV) administration. For this purpose, simvastatin levels in brain homogenates from sham or MCAOt rats at 2 hours or 4 hours after receiving the treatment were detected through ultra-high-protein liquid chromatography. Results: Whereas positively charged liposomes were not detected in brain or plasma 90 minutes after their administration, neutral and negatively charged liposomes were able to reach the brain and accumulate specifically in the infarcted area. Moreover, neutral liposomes exhibited higher bioavailability in plasma 4 hours after being administered. The detection of simvastatin by ultra-high-protein liquid chromatography confirmed its ability to cross the blood-brain barrier, when administered either as a free drug or encapsulated into liposomes. Conclusion: This study confirms that liposome charge is critical to promote its accumulation in the brain infarct after MCAOt. Furthermore, simvastatin can be delivered after being encapsulated. Thus, simvastatin encapsulation might be a promising strategy to ensure that the drug reaches the brain, while increasing its bioavailability and reducing possible side effects. © 2016 Campos-Martorell et al.
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Enhanced Spin Tunneling in a Molecular Magnet Mixed with a Superconductor
Tejada J., Zarzuela R., García-Santiago A., Imaz I., Espin J., Maspoch D., Chudnovsky E.M. Journal of Superconductivity and Novel Magnetism; 29 (5): 1133 - 1137. 2016. 10.1007/s10948-016-3474-6. IF: 1.100
We report characterization and magnetic studies of mixtures of micrometer-size ribbons of Mn12 acetate and micrometer-size particles of YBaCuO superconductor. Extremely narrow zero-field spin-tunneling resonance has been observed in the mixtures, pointing to the absence of the inhomogeneous dipolar broadening. It is attributed to the screening of the internal magnetic fields in the magnetic particles by Meissner currents flowing between superconducting grains surrounding the particles. © 2016, Springer Science+Business Media New York.
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Freezing the Nonclassical Crystal Growth of a Coordination Polymer Using Controlled Dynamic Gradients
Rubio-Martinez M., Imaz I., Domingo N., Abrishamkar A., Mayor T.S., Rossi R.M., Carbonell C., deMello A.J., Amabilino D.B., Maspoch D., Puigmartí-Luis J. Advanced Materials; : 8150 - 8155. 2016. 10.1002/adma.201506462. IF: 18.960
An experiment was conducted to show that diffusion-limited and kinetically controlled growth regimes occurring in microfluidic devices can provide valuable insights into crystallization processes. The microfluidic channels employed in this study were structured in PDMS master form fabricated by standard photolithographic techniques. Before attaching the cured and structured PDMS mould to a glass coverslip through plasma activation, inlet holes connecting the microfluidic channels were punched with a Biopsy puncher. The cross-sectional dimensions of the microchannels were 50 μm into 50 μm for the four input microchannels, and 250 μm into 50 μm for the main reactor channel. The total length of the main reactor channel was 9 mm. Data were indexed, integrated, and scaled using HKL2000 software. The H atoms were included in theoretical positions but not refined. The low max value was due to the data collection process, which was performed in the BM16 line with only a phi scan. The structure was solved by direct methods using the program SHELXS-97. The AFM results suggest that the early stage isolated seeds organize at a single level and in a perpendicular fashion, leading to the final plate-like crystalline morphologies observed in bulk and at an FFR of 0.1.
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Hetero-bimetallic paddlewheel clusters in coordination polymers formed by a water-induced single-crystal-to-single-crystal transformation
Albalad J., Aríñez-Soriano J., Vidal-Gancedo J., Lloveras V., Juanhuix J., Imaz I., Aliaga-Alcalde N., Maspoch D. Chemical Communications; 52 (91): 13397 - 13400. 2016. 10.1039/c6cc07653j. IF: 6.567
Herein we report a water-induced single-crystal to single-crystal transformation that involves the formation of hetero-bimetallic paddlewheel clusters in coordination polymers. Through this transformation, which involves the cleavage and formation of different coordination bonds, two different Cu(ii)-Zn(ii) and Cu(ii)-Ni(ii) paddlewheel units exhibiting a 1:1 metal ratio were created. © 2016 The Royal Society of Chemistry.
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Influence of the Amide Groups in the CO2/N2 Selectivity of a Series of Isoreticular, Interpenetrated Metal-Organic Frameworks
Safarifard V., Rodríguez-Hermida S., Guillerm V., Imaz I., Bigdeli M., Tehrani A.A., Juanhuix J., Morsali A., Casco M.E., Silvestre-Albero J., Ramos-Fernandez E.V., Maspoch D. Crystal Growth and Design; 16 (10): 6016 - 6023. 2016. 10.1021/acs.cgd.6b01054. IF: 4.425
Here we report the use of a pillaring strategy for the design and synthesis of three novel amide-functionalized metal-organic frameworks (MOFs), TMUs-22/-23/-24, isoreticular to the recently reported imine-functionalized TMU-6 and TMU-21 MOFs. An extensive study of their CO2 sorption properties and selectivity for CO2 over N2, from single gas sorption isotherms to breakthrough measurements, revealed that not only the incorporation of amide groups but also their accessibility is crucial to obtain enhanced CO2 sorption and CO2/N2 selectivity. Therefore, the MOF with more accessible amide groups (TMU-24) shows a CO2/N2 selectivity value of ca. 10 (as revealed by breakthrough experiments), which is ca. 500% and 700% of the selectivity values observed for the other amide-containing (TMU-22 and TMU-23) and imine-containing (TMU-6 and TMU-21) MOFs. © 2016 American Chemical Society.
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Introducing asymmetric functionality into MOFs: Via the generation of metallic Janus MOF particles
Ayala A., Carbonell C., Imaz I., Maspoch D. Chemical Communications; 52 (29): 5096 - 5099. 2016. 10.1039/c6cc01098a. IF: 6.567
Herein we report a versatile methodology for engineering metallic Janus MOF particles based on desymmetrization at interfaces, whereby each MOF particle is partially coated with a desired metal. We demonstrate that it enables the fabrication of homogeneous Janus MOF particles according to the MOF (ZIF-8, UiO-66 or UiO-66-SH), the metal (Au, Co or Pt), the MOF particle size (from the micrometer to the submicrometer regime) and the metal-film thickness (from 5 nm to 50 nm) employed. We anticipate that our strategy could be applied to impart new functionalities to MOFs, including asymmetric functionalization, magnetic-guidance and motorization. © The Royal Society of Chemistry 2016.
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Narrowing the Zero-Field Tunneling Resonance by Decreasing the Crystal Symmetry of Mn12 Acetate
Espín J., Zarzuela R., Statuto N., Juanhuix J., Maspoch D., Imaz I., Chudnovsky E., Tejada J. Journal of the American Chemical Society; 138 (29): 9065 - 9068. 2016. 10.1021/jacs.6b05380. IF: 13.038
We report the discovery of a less symmetric crystalline phase of Mn12 acetate, a triclinic phase, resulting from recrystallizing the original tetragonal phase reported by Lis in acetonitrile and toluene. This new phase exhibits the same structure of Mn12 acetate clusters and the same positions of tunneling resonances on the magnetic field as the conventional tetragonal phase. However, the width of the zero-field resonance is at least 1 order of magnitude smaller - can be as low as 50 Oe - indicating very small inhomogeneous broadening due to dipolar and nuclear fields. © 2016 American Chemical Society.
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pH-Responsive Relaxometric Behaviour of Coordination Polymer Nanoparticles Made of a Stable Macrocyclic Gadolinium Chelate
Aríñez-Soriano J., Albalad J., Carné-Sánchez A., Bonnet C.S., Busqué F., Lorenzo J., Juanhuix J., Terban M.W., Imaz I., Tóth É., Maspoch D. Chemistry - A European Journal; 22 (37): 13162 - 13170. 2016. 10.1002/chem.201602356. IF: 5.771
Lanthanide-containing nanoscale particles have been widely explored for various biomedical purposes, however, they are often prone to metal leaching. Here we have created a new coordination polymer (CP) by applying, for the first time, a stable GdIIIchelate as building block in order to prevent any fortuitous release of free lanthanide(III) ion. The use of the Gd-DOTA-4AmP complex as a design element in the CP allows not only for enhanced relaxometric properties (maximum r1=16.4 mm−1s−1at 10 MHz), but also for a pH responsiveness (Δr1=108 % between pH 4 and 6.5), beyond the values obtained for the low molecular weight Gd-DOTA-4AmP itself. The CP can be miniaturised to the nanoscale to form colloids that are stable in physiological saline solution and in cell culture media and does not show cytotoxicity. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
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Single-crystal and humidity-controlled powder diffraction study of the breathing effect in a metal-organic framework upon water adsorption/desorption
Aríñez-Soriano J., Albalad J., Vila-Parrondo C., Pérez-Carvajal J., Rodríguez-Hermida S., Cabeza A., Juanhuix J., Imaz I., Maspoch D. Chemical Communications; 52 (45): 7229 - 7232. 2016. 10.1039/c6cc02908f. IF: 6.567
Herein we report a study on water adsorption/desorption-triggered single-crystal to single-crystal transformations in a MOF, by single-crystal and humidity-controlled powder X-ray diffraction and water-sorption measurements. We identified a gate-opening effect at a relative humidity of 85% upon water adsorption, and a gate-closure effect at a relative humidity of 55 to 77% upon water desorption. This reversible breathing effect between the "open" and the "closed" structures of the MOF involves the cleavage and formation of several coordination bonds. © 2016 The Royal Society of Chemistry.
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Switchable Surface Hydrophobicity–Hydrophilicity of a Metal–Organic Framework
Rodríguez-Hermida S., Tsang M.Y., Vignatti C., Stylianou K.C., Guillerm V., Pérez-Carvajal J., Teixidor F., Viñas C., Choquesillo-Lazarte D., Verdugo-Escamilla C., Peral I., Juanhuix J., Verdaguer A., Imaz I., Maspoch D., Giner Planas J. Angewandte Chemie - International Edition; 55 (52): 16049 - 16053. 2016. 10.1002/anie.201609295. IF: 11.709
Materials with surfaces that can be switched from high/superhydrophobicity to superhydrophilicity are useful for myriad applications. Herein, we report a metal–organic framework (MOF) assembled from ZnIIions, 1,4-benzenedicarboxylate, and a hydrophobic carborane-based linker. The MOF crystal-surface can be switched between hydrophobic and superhydrophilic through a chemical treatment to remove some of the building blocks. © 2016 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
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Two-step synthesis of heterometallic coordination polymers using a polyazamacrocyclic linker
Aríñez-Soriano J., Albalad J., Pérez-Carvajal J., Imaz I., Busqué F., Juanhuix J., Maspoch D. CrystEngComm; 18 (22): 4196 - 4204. 2016. 10.1039/c5ce02520f. IF: 3.849
A new macrocyclic linker 1,4,7,10-tetraazacyclododecane-1,7-bis(4-acetamidobenzoic)-4,10-diacetic acid (H4L1) was synthesized and characterized. This linker was used to create two heterometallic coordination polymers following a two-step synthesis. This synthesis consisted of first combining this polyazamacrocyclic linker with Ni(ii) or Mn(ii) ions to obtain the corresponding metallomacrocyclic complexes showing non-coordinated carboxylic groups. In a second step, these metallated macrocycles were used as building units to construct two heterometallic Ni(ii)-Zn(ii) and Mn(ii)-Zn(ii) coordination polymers when combined with Zn(ii) ions. In addition, a third Zn(ii)-Zn(ii) coordination polymer could also be synthesized by direct mixing of H4L1 with Zn(ii) ions. Interestingly, the Mn(ii)-Zn(ii) coordination polymer exhibits a reversible type-I "crystal-to-amorphous transformation" upon water sorption/desorption. © The Royal Society of Chemistry.
2015
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Biomimetic Replication of Microscopic Metal-Organic Framework Patterns Using Printed Protein Patterns
Liang K., Carbonell C., Styles M.J., Ricco R., Cui J., Richardson J.J., Maspoch D., Caruso F., Falcaro P. Advanced Materials; 27 (45): 7293 - 7298. 2015. 10.1002/adma.201503167. IF: 17.493
An experiment was conducted to demonstrate that zeolitic imidazolate framework-8 (ZIF-8) and lanthanide ions (Ln2) (bdc)3 crystalline thin films and patterns can be formed as a result of biomimetic replication directly from protein patterns on various surfaces. This rapid process was performed in aqueous conditions at room temperature with a resolution in the micrometer range. Aqueous bovine serum albumin (BSA) solutions were prepared. A clean and dry ink pad was soaked in the BSA solution and removed. For the formation of ZIF-8 thin films and patterns, separate stock solutions of zinc acetate dehydrate and 2-methylimidazole were prepared in deionized water. These two solutions were mixed and immediately transferred onto the BSA patterns. After 12 h, the formed ZIF-8 patterns were washed three times in ethanol and dried under a stream of N2. For the formation of Ln2) (bdc)3 thin films and patterns, separate stock solutions of LnCl3 hydrate and terephthalic acid disodium salt were prepared in deionized water. These two solutions were mixed and immediately transferred onto the BSA patterns. After 30 s, the formed luminescent metal?organic frameworks (MOF) patterns were washed three times in deionized water and dried under a stream of N2.
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Direct On-Surface Patterning of a Crystalline Laminar Covalent Organic Framework Synthesized at Room Temperature
Delapeñaruigõmez A., Rodríguez-San-Miguel D., Stylianou K.C., Cavallini M., Gentili D., Liscio F., Milita S., Roscioni O.M., Ruiz-González M.L., Carbonell C., Maspoch D., Mas-Ballesté R., Segura J.L., Zamora F. Chemistry - A European Journal; 21 (30): 10666 - 10670. 2015. 10.1002/chem.201501692. IF: 5.731
We report herein an efficient, fast, and simple synthesis of an imine-based covalent organic framework (COF) at room temperature (hereafter, RT-COF-1). RT-COF-1 shows a layered hexagonal structure exhibiting channels, is robust, and is porous to N2 and CO2. The room-temperature synthesis has enabled us to fabricate and position low-cost micro- and submicropatterns of RT-COF-1 on several surfaces, including solid SiO2 substrates and flexible acetate paper, by using lithographically controlled wetting and conventional ink-jet printing. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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Engineering Homochiral Metal-Organic Frameworks by Spatially Separating 1D Chiral Metal-Peptide Ladders: Tuning the Pore Size for Enantioselective Adsorption
Stylianou K.C., Gõmez L., Imaz I., Verdugo-Escamilla C., Ribas X., Maspoch D. Chemistry - A European Journal; 21 (28): 9964 - 9969. 2015. 10.1002/chem.201501315. IF: 5.731
The reaction of the chiral dipeptide glycyl-L(S)-glutamate with CoII ions produces chiral ladders that can be used as rigid 1D building units. Spatial separation of these building units with linkers of different lengths allows the engineering of homochiral porous MOFs with enhanced pore sizes, pore volumes, and surface areas. This strategy enables the synthesis of a family of isoreticular MOFs, in which the pore size dictates the enantioselective adsorption of chiral molecules (in terms of their size and enantiomeric excess). © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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Healing damaged coatings using friction-sensitive hybrid microcapsules
García-Jimeno S., Cano-Sarabia M., Mejias N., Navarro V., Frances A.B., Maspoch D. Journal of Materials Chemistry A; 3 (35): 17966 - 17970. 2015. 10.1039/c5ta04147c. IF: 7.443
A new healing surface coating technology based on the incorporation of hybrid melamine-formaldehyde-polyurethane (MF/PU) microcapsules which contain a healing mixture, into standard polyurethane surface coatings, is described. Microcapsules release the healing mixture upon surface scratching after mechanical damage. © The Royal Society of Chemistry 2015.
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Lanthanide-organic framework nanothermometers prepared by spray-drying
Wang Z., Ananias D., Carné-Sánchez A., Brites C.D.S., Imaz I., Maspoch D., Rocha J., Carlos L.D. Advanced Functional Materials; 25 (19): 2824 - 2830. 2015. 10.1002/adfm.201500518. IF: 11.805
Accurate, noninvasive, and self-referenced temperature measurements at the submicrometer scale are of great interest, prompted by the ever-growing demands in the fields of nanotechnology and nanomedicine. The thermal dependence of the phosphor's luminescence provides high detection sensitivity and spatial resolution with short acquisition times in, e.g., biological fluids, strong electromagnetic fields, and fast-moving objects. Here, it is shown that nanoparticles of [(Tb
0.914 Eu0.086 )2 (PDA)3 (H2 O)]·2H2 O (PDA = 1,4-phenylenediacetic acid), the first lanthanide-organic framework prepared by the spray-drying method, are excellent nanothermometers operating in the solid state in the 10-325 K range (quantum yield of 0.25 at 370 nm, at room temperature). Intriguingly, this system is the most sensitive cryogenic nanothermometer reported so far, combining high sensitivity (up to 5.96 ± 0.04% K-1 at 25 K), reproducibility (in excess of 99%), and low-temperature uncertainty (0.02 K at 25 K). One of the most sensitive cryogenic thermometers (5.96% K-1 at 25 K) reported so far is described, consisting of lanthanide (Tb3+, Eu3+) organic framework nanoparticles prepared by spray-drying, exhibiting an excellent reproducibility (>99%) and low-temperature uncertainty (0.02 K at 25 K). © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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Liposome-encapsulated bacteriophages for enhanced oral phage therapy against Salmonella spp.
Colom J., Cano-Sarabia M., Otero J., Cortés P., Maspoch D., Llagostera M. Applied and Environmental Microbiology; 81 (14): 4841 - 4849. 2015. 10.1128/AEM.00812-15. IF: 3.668
Bacteriophages UAB_Phi20, UAB_Phi78, and UAB_Phi87 were encapsulated in liposomes, and their efficacy in reducing Salmonella in poultry was then studied. The encapsulated phages had a mean diameter of 309 to 326 nm and a positive charge between +31.6 and +35.1 mV (pH 6.1). In simulated gastric fluid (pH 2.8), the titer of nonencapsulated phages decreased by 5.7 to 7.8 log units, whereas encapsulated phages were significantly more stable, with losses of 3.7 to 5.4 log units. The liposome coating also improved the retention of bacteriophages in the chicken intestinal tract. When cocktails of the encapsulated and nonencapsulated phages were administered to broilers, after 72 h the encapsulated phages were detected in 38.1% of the animals, whereas the nonencapsulated phages were present in only 9.5%. The difference was significant. In addition, in an in vitro experiment, the cecal contents of broilers promoted the release of the phages from the liposomes. In broilers experimentally infected with Salmonella, the daily administration of the two cocktails for 6 days postinfection conferred similar levels of protection against Salmonella colonization. However, once treatment was stopped, protection by the nonencapsulated phages disappeared, whereas that provided by the encapsulated phages persisted for at least 1 week, showing the enhanced efficacy of the encapsulated phages in protecting poultry against Salmonella over time. The methodology described here allows the liposome encapsulation of phages of different morphologies. The preparations can be stored for at least 3 months at 4°C and could be added to the drinking water and feed of animals. © 2015, American Society for Microbiology.
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Optimised room temperature, water-based synthesis of CPO-27-M metal-organic frameworks with high space-time yields
Garzón-Tovar L., Carné-Sánchez A., Carbonell C., Imaz I., Maspoch D. Journal of Materials Chemistry A; 3 (41): 20819 - 20826. 2015. 10.1039/c5ta04923g. IF: 7.443
The exceptional porosity of Metal-Organic Frameworks (MOFs) could be harnessed for countless practical applications. However, one of the challenges currently precluding the industrial exploitation of these materials is a lack of green methods for their synthesis. Since green synthetic methods obviate the use of organic solvents, they are expected to reduce the production costs, safety hazards and environmental impact typically associated with MOF fabrication. Herein we describe the stepwise optimisation of reaction parameters (pH, reagent concentrations and reaction time) for the room temperature, water-based synthesis of several members of the CPO-27/MOF-74-M series of MOFs, including ones made from Mg(ii), Ni(ii), Co(ii) and Zn(ii) ions. Using this method, we built MOFs with excellent BET surface areas and unprecedented Space-Time Yields (STYs). Employing this approach, we have synthesised CPO-27-M MOFs with record BET surface areas, including 1279 m2 g-1 (CPO-27-Zn), 1351 m2 g-1 (CPO-27-Ni), 1572 m2 g-1 (CPO-27-Co), and 1603 m2 g-1 (CPO-27-Mg). We anticipate that our method could be applied to produce CPO-27-Ni, -Mg, -Co and -Zn with STYs of 44 kg m-3 per day, 191 kg m-3 per day, 1462 kg m-3 per day and a record 18720 kg m-3 per day, respectively. © The Royal Society of Chemistry.
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Post-Synthetic Anisotropic Wet-Chemical Etching of Colloidal Sodalite ZIF Crystals
Avci C., Ariñez-Soriano J., Carné-Sánchez A., Guillerm V., Carbonell C., Imaz I., Maspoch D. Angewandte Chemie - International Edition; 54 (48): 14417 - 14421. 2015. 10.1002/anie.201507588. IF: 11.261
Controlling the shape of metal-organic framework (MOF) crystals is important for understanding their crystallization and useful for myriad applications. However, despite the many advances in shaping of inorganic nanoparticles, post-synthetic shape control of MOFs and, in general, molecular crystals remains embryonic. Herein, we report using a simple wet-chemistry process at room temperature to control the anisotropic etching of colloidal ZIF-8 and ZIF-67 crystals. Our work enables uniform reshaping of these porous materials into unprecedented morphologies, including cubic and tetrahedral crystals, and even hollow boxes, by an acid-base reaction and subsequent sequestration of leached metal ions. Etching tests on these ZIFs reveal that etching occurs preferentially in the crystallographic directions richer in metal-ligand bonds; that, along these directions, the etching rate tends to be faster on the crystal surfaces of higher dimensionality; and that the etching can be modulated by adjusting the pH of the etchant solution. © 2015 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
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Protecting metal-organic framework crystals from hydrolytic degradation by spray-dry encapsulating them into polystyrene microspheres
Carné-Sánchez A., Stylianou K.C., Carbonell C., Naderi M., Imaz I., Maspoch D. Advanced Materials; 27 (5): 869 - 873. 2015. 10.1002/adma.201403827. IF: 17.493
A one-step, alternative, rapid, and scalable spray-drying (SD) synthesis of metal-organic frameworks (MOF)@polymer composites with enhanced hydrolytic stabilities was reported. SD was used to encapsulate preformed MOF crystals in a polymeric matrix to generate microscale MOF@polymer spheres. For proof-of-concept Hong-Kong University of Science and Technology-1 (HKUST-1) was chosen as the water-sensitive MOF, and polystyrene (PS) as the organic polymer. The synthesis of HKUST-1@PS began with preparation of a stable colloidal suspension of HKUST-1 crystals and a solution of PS in dichloromethane (DCM). This mixture was atomized using a two-fluid nozzle. After 40 min of continuous spraying, 1.7 g of a blue powder was recovered. The sample was then washed with ethanol and dried at 120°C under vacuum. This product was analyzed through field-emission scanning electron microscopy (FESEM), which indicated that it comprised smooth microspheres of HKUST-1@PS composites and did not contain any free HKUST-1. X-ray powder diffraction (XRPD) analysis of these spheres revealed a perfect match with the HKUST-1 pattern. The exclusive presence of microspheres and the match in XRPD patterns evidenced that HKUST-1 crystals were indeed entrapped within the polymeric matrix of PS.
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Resonant spin tunneling in randomly oriented nanospheres of Mn12 acetate
Lendínez S., Zarzuela R., Tejada J., Terban M.W., Billinge S.J.L., Espin J., Imaz I., Maspoch D., Chudnovsky E.M. Physical Review B - Condensed Matter and Materials Physics; 91 (2, 024404) 2015. 10.1103/PhysRevB.91.024404. IF: 3.736
We report measurements and theoretical analysis of resonant spin tunneling in randomly oriented nanospheres of a molecular magnet. Amorphous nanospheres of Mn12 acetate have been fabricated and characterized by chemical, infrared, TEM, x-ray, and magnetic methods. Magnetic measurements have revealed sharp tunneling peaks in the field derivative of the magnetization that occur at the typical resonant field values for the Mn12 acetate crystal in the field parallel to the easy axis. Theoretical analysis is provided that explains these observations. We argue that resonant spin tunneling in a molecular magnet can be established in a powder sample, without the need for a single crystal and without aligning the easy magnetization axes of the molecules. This is confirmed by reanalyzing the old data on a powdered sample of nonoriented micron-size crystals of Mn12 acetate. Our findings can greatly simplify the selection of candidates for quantum spin tunneling among newly synthesized molecular magnets. © 2015 American Physical Society.
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Synthesis, culture medium stability, and in vitro and in vivo zebrafish embryo toxicity of metal-organic framework nanoparticles
Ruyra A., Yazdi A., Espín J., Carné-Sánchez A., Roher N., Lorenzo J., Imaz I., Maspoch D. Chemistry - A European Journal; 21 (6): 2508 - 2518. 2015. 10.1002/chem.201405380. IF: 5.731
Metal-organic frameworks (MOFs) are among the most attractive porous materials available today. They have garnered much attention for their potential utility in many different areas such as gas storage, separation, catalysis, and biomedicine. However, very little is known about the possible health or environmental risks of these materials. Here, the results of toxicity studies on sixteen representative uncoated MOF nanoparticles (nanoMOFs), which were assessed for cytotoxicity to HepG2 and MCF7 cells in vitro, and for toxicity to zebrafish embryos in vivo, are reported. Interestingly, there is a strong correlation between their in vitro toxicity and their in vivo toxicity. NanoMOFs were ranked according to their respective in vivo toxicity (in terms of the amount and severity of phenotypic changes observed in the treated zebrafish embryos), which varied widely. Altogether these results show different levels of toxicity of these materials; however, leaching of solubilized metal ions plays a main role. © 2015 Wiley-VCH Verlag GmbH & Co. KGaA.
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Two New Adenine-Based Co(II) Coordination Polymers: Synthesis, Crystal Structure, Coordination Modes, and Reversible Hydrochromic Behavior
Burneo I., Stylianou K.C., Rodríguez-Hermida S., Juanhuix J., Fontrodona X., Imaz I., Maspoch D. Crystal Growth and Design; 15 (7): 3182 - 3189. 2015. 10.1021/acs.cgd.5b00218. IF: 4.891
We report the synthesis of two new three-dimensional coordination polymers (CPs) based on Co(II), adenine, and aromatic tetracarboxylate linkers. Adenine exhibits bidentate binding modes in both CPs, coordinating through the N
3 and N9 sites in a first compact CP and through the more rare N3 and N7 sites in a second open, flexible, and H2 O-responsive CP. These differences together with an analysis of the extended coordination structures made of adenine reported in the Cambridge Structural Database illustrate the rich coordination versatility of adenine as a building block for CPs. Although the latter CP is nonporous to N2 or CO2 , it shows a reversible and detectable color change from pink to purple, and vice versa, upon hydration and dehydration, respectively. (Graph Presented). © 2015 American Chemical Society.
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Use of autoantigen-loaded phosphatidylserine-liposomes to arrest autoimmunity in type 1 diabetes
Pujol-Autonell I., Serracant-Prat A., Cano-Sarabia M., Ampudia R.M., Rodriguez-Fernandez S., Sanchez A., Izquierdo C., Stratmann T., Puig-Domingo M., Maspoch D., Verdaguer J., Vives-Pi M. PLoS ONE; 10 (6, e0127057) 2015. 10.1371/journal.pone.0127057. IF: 3.234
Introduction: The development of new therapies to induce self-tolerance has been an important medical health challenge in type 1 diabetes. An ideal immunotherapy should inhibit the autoimmune attack, avoid systemic side effects and allow β-cell regeneration. Based on the immunomodulatory effects of apoptosis, we hypothesized that apoptotic mimicry can help to restore tolerance lost in autoimmune diabetes. Objective: To generate a synthetic antigen-specific immunotherapy based on apoptosis features to specifically reestablish tolerance to β-cells in type 1 diabetes. Methods: A central event on the surface of apoptotic cells is the exposure of phosphatidylserine, which provides the main signal for efferocytosis. Therefore, phosphatidylserine-liposomes loaded with insulin peptides were generated to simulate apoptotic cells recognition by antigen presenting cells. The effect of antigen-specific phosphatidylserine-liposomes in the reestablishment of peripheral tolerance was assessed in NOD mice, the spontaneous model of autoimmune diabetes. MHC class II-peptide tetramers were used to analyze the T cell specific response after treatment with phosphatidylserine-liposomes loaded with peptides. Results: We have shown that phosphatidylserine-liposomes loaded with insulin peptides induce tolerogenic dendritic cells and impair autoreactive T cell proliferation. When administered to NOD mice, liposome signal was detected in the pancreas and draining lymph nodes. This immunotherapy arrests the autoimmune aggression, reduces the severity of insulitis and prevents type 1 diabetes by apoptotic mimicry. MHC class II tetramer analysis showed that peptide-loaded phosphatidylserine-liposomes expand antigen-specific CD4+ T cells in vivo. The administration of phosphatidylserine-free liposomes emphasizes the importance of phosphatidylserine in the modulation of antigen-specific CD4+ T cell expansion. Conclusions: We conclude that this innovative immunotherapy based on the use of liposomes constitutes a promising strategy for autoimmune diseases. © 2015 Pujol-Autonell et al.
2014
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Localized, stepwise template growth of functional nanowires from an amino acid-supported framework in a microfluidic chip
Puigmartí-Luis, J.; Rubio-Martínez, M.; Imaz, I.; Cvetkovic, B.Z.; Abad, L.; Pérez Del Pino, A.; Maspoch, D.; Amabilino, D.B. ACS Nano; 8 (1): 818 - 826. 2014. 10.1021/nn4054864. IF: 12.033
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Metal-organic frameworks: From molecules/metal ions to crystals to superstructures
Carné-Sánchez, A.; Imaz, I.; Stylianou, K.C.; Maspoch, D. Chemistry - A European Journal; 20 (18): 5192 - 5201. 2014. 10.1002/chem.201304529. IF: 5.696
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Selective CO2 capture in metal-organic frameworks with azine-functionalized pores generated by mechanosynthesis
Masoomi, M.Y.; Stylianou, K.C.; Morsali, A.; Retailleau, P.; Maspoch, D. Crystal Growth and Design; 14 (5): 2092 - 2096. 2014. 10.1021/cg500033b. IF: 4.558
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Sponge-like molecular cage for purification of fullerenes
García-Simón, C.; Garcia-Borràs, M.; Gómez, L.; Parella, T.; Osuna, S.; Juanhuix, J.; Imaz, I.; Maspoch, D.; Costas, M.; Ribas, X. Nature Communications; 2014. 10.1038/ncomms6557. IF: 10.742
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Targeting and stimulation of the zebrafish (Danio rerio) innate immune system with LPS/dsRNA-loaded nanoliposomes
Ruyra, A.; Cano-Sarabia, M.; García-Valtanen, P.; Yero, D.; Gibert, I.; Mackenzie, S.A.; Estepa, A.; Maspoch, D.; Roher, N. Vaccine; 32 (31): 3955 - 3962. 2014. 10.1016/j.vaccine.2014.05.010. IF: 3.485
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The influence of the enantiomeric ratio of an organic ligand on the structure and chirality of metal-organic frameworks
Burneo, I.; Stylianou, K.C.; Imaz, I.; Maspoch, D. Chemical Communications; 50 (89): 13829 - 13832. 2014. 10.1039/c4cc06190j. IF: 6.718
2013
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A Novel Liposome-Based Nanocarrier Loaded with an LPS-dsRNA Cocktail for Fish Innate Immune System Stimulation
Ruyra, A.; Cano-Sarabia, M.; MacKenzie, S.A.; Maspoch, D.; Roher, N. PLoS ONE; 8 (10) 2013. 10.1371/journal.pone.0076338. IF: 3.730
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A spray-drying strategy for synthesis of nanoscale metal-organic frameworks and their assembly into hollow superstructures
Carné-Sánchez, A.; Imaz, I.; Cano-Sarabia, M.; Maspoch, D. Nature Chemistry; 5: 203 - 211. 2013. 10.1038/nchem.1569. IF: 21.757
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Dual-Template synthesis of one-dimensional conductive nanoparticle superstructures from coordination metal-peptide polymer crystals
Rubio-Martínez, M.; Puigmartí-Luis, J.; Imaz, I.; Dittrich, P.S.; Maspoch, D. Small; 9 (24): 4160 - 4167. 2013. 10.1002/smll.201301338. IF: 7.823
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Femtolitre chemistry assisted by microfluidic pen lithography
Carbonell, C. ; Stylianou, K. C. ; Hernando, J.; Evangelio, E. ; Barnett, S. A.; Nettikadan, S. ; Imaz, I.; Maspoch, D. Nature Communications; 4: 2173. 2013. 10.1038/ncomms3173. IF: 10.015
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Relaxometry studies of a highly stable nanoscale metal-organic framework made of Cu(II), Gd(III), and the macrocyclic DOTP
Carné-Sánchez, A.; Bonnet, C.S.; Imaz, I.; Lorenzo, J.; Tóth, E.; Maspoch, D. Journal of the American Chemical Society; 135 (47): 17711 - 17714. 2013. 10.1021/ja4094378. IF: 10.677
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Self-assembled tetragonal prismatic molecular cage highly selective for anionic π guests
GarcÃa-Simón, C.; Garcia-Borrà s, M.; Gómez, L.; Garcia-Bosch, I.; Osuna, S.; Swart, M.; Luis, J.M.; Rovira, C.; Almeida, M.; Imaz, I.; Maspoch, D.; Costas, M.; Ribas, X. Chemistry - A European Journal; 19: 1445 - 1456. 2013. 10.1002/chem.201203376. IF: 5.831
2012
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Three-dimensional porous metal-radical frameworks based on triphenylmethyl radicals
Datcu, A.; Roques, N.; Jubera, V.; Maspoch, D.; Fontrodona, X.; Wurst, K.; Imaz, I.; Mouchaham, G.; Sutter, J.-P.; Rovira, C.; Veciana, J. Chemistry - A European Journal; 18: 152 - 162. 2012. 10.1002/chem.201102278.
2011
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Controlling the length and location of in situ formed nanowires by means of microfluidic tools
Kuhn, P.; Puigmartí-Luis, J.; Imaz, I.; Maspoch, D.; Dittrich, P.S. Lab on a Chip - Miniaturisation for Chemistry and Biology; 11: 753 - 757. 2011. 10.1039/c0lc00270d.
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Coordination polymer nanofibers generated by microfluidic synthesis
Puigmartí-Luis, J.; Rubio-Martínez, M.; Hartfelder, U.; Imaz, I.; Maspoch, D.; Dittrich, P.S. Journal of the American Chemical Society; 133: 4216 - 4219. 2011. 10.1021/ja110834j.
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Metal-biomolecule frameworks (MBioFs)
Imaz, I.; Rubio-Martínez, M.; An, J.; Solé-Font, I.; Rosi, N.L.; Maspoch, D. Chemical Communications; 47: 7287 - 7302. 2011. 10.1039/c1cc11202c.
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Multiplexed arrays of chemosensors by parallel dip-pen nanolithography
Martínez-Otero, A.; González-Monje, P.; Maspoch, D.; Hernando, J.; Ruiz-Molina, D. Chemical Communications; 47: 6864 - 6866. 2011. 10.1039/c0cc03838e.
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Nanoscale metal-organic materials
Carné, A.; Carbonell, C.; Imaz, I.; Maspoch, D. Chemical Society Reviews; 40: 291 - 305. 2011. 10.1039/c0cs00042f.
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Single-crystal metal-organic framework arrays
Carbonell, C.; Imaz, I.; Maspoch, D. Journal of the American Chemical Society; 133: 2144 - 2147. 2011. 10.1021/ja2002428.
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Three-dimensional open-frameworks based on LnIII ions and open-/closed-Shell PTM ligands: Synthesis, structure, luminescence, and magnetic properties
Datcu, A.; Roques, N.; Jubera, V.; Imaz, I.; Maspoch, D.; Sutter, J.-P.; Rovira, C.; Veciana, J. Chemistry - A European Journal; 17: 3644 - 3656. 2011. 10.1002/chem.201002993.
2010
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Controlling the number of proteins with dip-pen nanolithography
Bellido, E.; De Miguel, R.; Ruiz-Molina, D.; Lostao, A.; Maspoch, D. Advanced Materials; 22: 352 - 355. 2010. 10.1002/adma.200902372.
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Coordination polymer particles as potential drug delivery systems
Imaz, I.; Rubio-Martínez, M.; García-Fernández, L.; García, F.; Ruiz-Molina, D.; Hernando, J.; Puntes, V.; Maspoch, D. Chemical Communications; 46: 4737 - 4739. 2010. 10.1039/c003084h.
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Formation of metal-bioorganic nanofibres on a microchip
Hartfelder, U.; Puigmartí-Luis, J.; Imaz, I.; Maspoch, D.; Dittrich, P.S. European Cells and Materials; 20: 103. 2010. .
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Metal-radical chains based on polychlorotriphenylmethyl radicals: Synthesis, structure, and magnetic properties
Roques, N.; Domingo, N.; Maspoch, D.; Wurst, K.; Rovira, C.; Tejada, J.; Ruiz-Molina, D.; Veciana, J. Inorganic Chemistry; 49: 3482 - 3488. 2010. 10.1021/ic100037z.
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Nanoscale positioning of inorganic nanoparticles using biological ferritin arrays fabricated by Dip-Pen Nanolithography
Bellido, E.; De Miguel, R.; Sesé, J.; Ruiz-Molina, D.; Lostao, A.; Maspoch, D. Scanning; 32: 35 - 41. 2010. 10.1002/sca.20162.
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Towards nanowire sensors on a microfluidic platform: In-situ formation, positioning and sizing of nanowire bundles
Kuhn, P.; Puigmartí-Luis, J.; Imaz, I.; Maspoch, D.; Dittrich, P.S. European Cells and Materials; 20: 58. 2010. .
2009
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Amino acid based metal-organic nanofibers
Imaz, I.; Rubio-Martínez, M.; Saletra, W.J.; Amabilino, D.B.; Maspoch, D. Journal of the American Chemical Society; 131: 18222 - 18223. 2009. 10.1021/ja908721t.
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Electrically biased nanolithography with KOH coated AFM tips
J.-W. Jang; R. Sanedrin; D. Maspoch; S. Hwang; T. Fujigaya; Y. M. Jeon; R. Vega; X. Chen; C. A. Mirkin. Nano Letters; 8 (5): 1451 - 1455. 2009. 10.1021/nl080418b.
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Metal-organic spheres as functional systems for guest encapsulation
Imaz, I.; Hernando, J.; Ruiz-Molina, D.; Maspoch, D. Angewandte Chemie - International Edition; 48: 2325 - 2329. 2009. .
2008
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A hexacarboxylic open-shell building block: Synthesis, structure and magnetism of a three-dimensional metal-radical framework
Roques, N.; Maspoch, D.; Luis, F.; Camón, A.; Wurst, K.; Datcu, A.; Rovira, C.; Ruiz-Molina, D.; Veciana, J. Journal of Materials Chemistry; 18: 98 - 108. 2008. 10.1039/b713705b.
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Magnetic behaviour of Mn12 single-molecule magnet nanospheres
Carbonera, C.; Imaz, I.; Maspoch, D.; Ruiz-Molina, D.; Luis, F. Inorganica Chimica Acta; 361: 3951 - 3956. 2008. 10.1016/j.ica.2008.03.037.
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pH-responsive fluorescent nanoarrays fabricated by direct-write parallel dip-pen nanolithography
Martínez-Otero, A.; Hernando, J.; Ruiz-Molina, D.; Maspoch, D. Small; 4: 2131 - 2135. 2008. 10.1002/smll.200800481.
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Single-molecule magnet behaviour in metal-organic nanospheres generated by simple precipitation of Mn12O12 clusters
Imaz, I.; Luis, F.; Carbonera, C.; Ruiz-Molina, D.; Maspoch, D. Chemical Communications; : 1202 - 1204. 2008. 10.1039/b716071b.
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Superparamagnetic Sub-5 nm Fe@C Nanoparticles: Isolation, Magnetic Properties, and Directed Assembly
Y. Wang; W. Wei; D. Maspoch; J. Wu; V. Dravid; C. A. Mirkin. Nano Letters; 8: 3761 - 3765. 2008. 10.1021/nl8020768.
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Synthesis, X-ray structure and reactivity of a sterically protected azobisphenol ligand: On the quest for new multifunctional active ligands
Evangelio, E.; Saiz-Poseu, J.; Maspoch, D.; Wurst, K.; Busque, F.; Ruiz-Molina, D. European Journal of Inorganic Chemistry; : 2278 - 2285. 2008. 10.1002/ejic.200701339.
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Valence-tautomeric metal-organic nanoparticles
Imaz, I.; Maspoch, D.; Rodríguez-Blanco, C.; Pérez-Falcón, J.M.; Campo, J.; Ruiz-Molina, D. Angewandte Chemie - International Edition; 47: 1857 - 1860. 2008. 10.1002/anie.200705263.
2007
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Europium (III) complexes derived from carboxylic substituted polychlorotriphenylmethyl radicals
N. Roques; S. Perruchas; D. Maspoch; A. Datcu; K. Wurst; J.-P. Sutter; C. Rovira; J. Veciana. Inorganica Chimica Acta; 360: 3861 - 3869. 2007. .
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First-row transition-metal complexes based on a carboxylate polychlorotriphenylmethyl radical: Trends in metal-radical exchange interactions
Maspoch, D.; Domingo, N.; Ruiz-Molina, D.; Wurst, K.; Hernández, J.M.; Lloret, F.; Tejada, J.; Rovira, C.; Veciana, J. Inorganic Chemistry; 46: 1627 - 1633. 2007. 10.1021/ic061815x.
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Old materials with new tricks: multifunctional open-framework materials
D. Maspoch; D. Ruiz-Molina; J. Veciana Chemical Society Reviews; 2007. .
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Self-assembly of carboxylic substituted PTM radicals: from weak ferromagnetic interactions to porous magnets
N. Roques; D. Maspoch; K. Wurst; D. Ruiz-Molina; C. Rovira; J. Veciana Polyhedron; 26: 1934. 2007. .
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Structural and magnetic modulation of a purely organic open framework by selective guest inclusion
Maspoch, D.; Domingo, N.; Roques, N.; Wurst, K.; Tejada, J.; Rovira, C.; Ruiz-Molina, D.; Veciana, J. Chemistry - A European Journal; 13: 8153 - 8163. 2007. 10.1002/chem.200700353.
2006
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Three-dimensional six-connecting organic building blocks based on polychlorotriphenylmethyl units - Synthesis, self-assembly, and magnetic properties
Roques, N.; Maspoch, D.; Wurst, K.; Ruiz-Molina, D.; Rovira, C.; Veciana, J. Chemistry - A European Journal; 12: 9238 - 9253. 2006. 10.1002/chem.200600447.
2005
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An unusually stable trinuclear manganese(II) complex bearing bulk carboxylic radical ligands
Maspoch, D.; Gómez-Segura, J.; Domingo, N.; Ruiz-Molina, D.; Wurst, K.; Rovira, C.; Tejada, J.; Veciana, J. Inorganic Chemistry; 44: 6936 - 6938. 2005. 10.1021/ic050977a.
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Carboxylic-substituted polychlorotriphenylmethyl radicals, new organic building-blocks to design nanoporous magnetic molecular materials
Maspoch, D.; Domingo, N.; Ruiz-Molina, D.; Wurst, K.; Tejada, J.; Rovira, C.; Veciana, J. Comptes Rendus Chimie; 8: 1213 - 1225. 2005. 10.1016/j.crci.2005.02.020.
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Coexistence of ferro- and antiferromagnetic interactions in a metal-organic radical-based (6,3)-helical network with large channels
Maspoch, D.; Domingo, N.; Ruiz-Molina, D.; Wurst, K.; Hernández, J.-M.; Vaughan, G.; Rovira, C.; Lloret, F.; Tejada, J.; Veciana, J. Chemical Communications; : 5035 - 5037. 2005. 10.1039/b505827a.
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Hydrogen-bonded self-assemblies in a polychlorotriphenylmethyl radical derivative substituted with six meta-carboxylic acid groups
Roques, N.; Maspoch, D.; Domingo, N.; Ruiz-Molina, D.; Wurst, K.; Tejada, J.; Rovira, C.; Veciana, J. Chemical Communications; : 4801 - 4803. 2005. 10.1039/b508952b.
2004
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A new (63)·(69.81) non-interpenetrated paramagnetic network with helical nanochannels based on a tricarboxylic perchlorotriphenylmethyl radical
Maspoch, D.; Ruiz-Molina, D.; Wurst, K.; Rovira, C.; Veciana, J. Chemical Communications; 10: 1164 - 1165. 2004. .
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A Robust Nanocontainer Based on a Pure Organic Free Radical
Maspoch, D.; Domingo, N.; Ruiz-Molina, D.; Wurst, K.; Tejada, J.; Rovira, C.; Veciana, J. Journal of the American Chemical Society; 126: 730 - 731. 2004. 10.1021/ja038988v.
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A robust purely organic nanoporous magnet
Maspoch, D.; Domingo, N.; Ruiz-Molina, D.; Wurst, K.; Vaughan, G.; Tejada, J.; Rovira, C.; Veciana, J. Angewandte Chemie - International Edition; 43: 1828 - 1832. 2004. 10.1002/anie.200353358.
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EPR Characterization of a Nanoporous Metal-Organic Framework Exhibiting a Bulk Magnetic Ordering
D. Maspoch; J. Vidal-Gancedo; D. Ruiz-Molina; C. Rovira; J. Veciana Journal of Physics and Chemistry of Solids; 65: 819. 2004. 10.1016/j/jpcs.2003.11.026.
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Magnetic nanoporous coordination polymers
Maspoch, D.; Ruiz-Molina, D.; Veciana, J. Journal of Materials Chemistry; 14: 2713 - 2723. 2004. 10.1039/b407169g.
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Open-shell channel-like salts formed by the supramolecular assembly of a tricarboxylated perchlorotriphenylmethyl radical and a [Co(bpy) 3]2+ cation
Maspoch, D.; Ruiz-Molina, D.; Wurst, K.; Vaughan, G.; Domingo, N.; Tejada, J.; Rovira, C.; Veciana, J. CrystEngComm; 6: 573 - 578. 2004. 10.1039/b410810h.
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Synthesis, structural and magnetic properties of a series of copper(ii) complexes containing a monocarboxylated perchlorotriphenylmethyl radical as a coordinating open-shell ligand
Maspoch, D.; Ruiz-Molina, D.; Wurst, K.; Vidal-Gancedo, J.; Rovira, C.; Veciana, J. Dalton Transactions; : 1073 - 1082. 2004. .